ID   DPOL_MUHVS              Reviewed;        1097 AA.
AC   P27172;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   29-SEP-2021, entry version 99.
DE   RecName: Full=DNA polymerase catalytic subunit;
DE            EC=2.7.7.7;
GN   Name=UL54;
OS   Murid herpesvirus 1 (strain Smith) (MuHV-1) (Mouse cytomegalovirus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Muromegalovirus.
OX   NCBI_TaxID=10367;
OH   NCBI_TaxID=10090; Mus musculus (Mouse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1718083; DOI=10.1016/0042-6822(91)90765-4;
RA   Elliott R., Clark C., Jaquish D., Spector D.H.;
RT   "Transcription analysis and sequence of the putative murine cytomegalovirus
RT   DNA polymerase gene.";
RL   Virology 185:169-186(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8971012; DOI=10.1128/jvi.70.12.8833-8849.1996;
RA   Rawlinson W.D., Farrell H.E., Barrell B.G.;
RT   "Analysis of the complete DNA sequence of murine cytomegalovirus.";
RL   J. Virol. 70:8833-8849(1996).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SUBCELLULAR LOCATION: Host nucleus.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family. {ECO:0000305}.
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DR   EMBL; M73549; AAA45940.1; -; Genomic_DNA.
DR   EMBL; U68299; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; B40780; DJBEMC.
DR   SMR; P27172; -.
DR   PRIDE; P27172; -.
DR   Proteomes; UP000008774; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR042087; DNA_pol_B_thumb.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; DNA-directed DNA polymerase; Host nucleus;
KW   Nucleotidyltransferase; Reference proteome; Transferase;
KW   Viral DNA replication.
FT   CHAIN           1..1097
FT                   /note="DNA polymerase catalytic subunit"
FT                   /id="PRO_0000046508"
FT   REGION          1069..1097
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1071..1097
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1097 AA;  123574 MW;  07310048ACC350BD CRC64;
     MDTCVETFFN PYLRRKPRRD WRRCEDNNKN FLQVVPRGVL YDGATGLIKV QSGMEPRMFY
     AEKEYVLNPD KPWPTLRTRG WCRGPYSDDV RFHTYDQVVN LVLADSDEQI SPRWNSHVVP
     AGNVIRMFGA TDEGVSVCVN VFGQKAYFYC ERMQSEDLKN TVYDIADKVP EPCSPFSVSI
     SPVTKSSFYG YGLGHIPNLY RLSFNNWNMC RKIGKRMLEE GRKVYELGVD PLARFLIDRK
     IPSFGWCLAR RYSVRAAGYV SRAQLEIDCD VADILPIEEQ SNWPFYRCLS FDIECMSGTG
     AFPAAENVDD IIIQISCVCF GVGEMVHHAY DVHADLSTPA VPENHLFTIG PCAPIPDVKI
     YTFPSEYEML RGFFIFLSWY SPEFITGYNI NGFDIKYILT RAEKLYKMDV GQFTKLRRGG
     RMFVFSPEKG KAGFGTSNTV KVFWSGTVVL DMYPVCTAKA SSPNYKLDTM AEIYLKKKKD
     DLSYKEIPVQ FSAGDEGRAP GGKYCLQDAV LVRELFEMLA FHFEAAAIAR LARIPLRKVI
     FDGQQIRIYT CLLEECSGRD MILPNMPSLG HGAAAAIEEA AAGGEGDETS EGENSNNSRT
     VGYQGATVLE PECGFHHVPV CVFDFASLYP SIIMSNNLCY STLLVEGSPE VPEKDVLRVE
     IGDQCHRFVR ENVHRSLLAE LLVRWLTQRK LVREAMKQCT NEMQRMIMDK QQLALKVTCN
     AFYGFTGVAA GMLPCLPIAA SITKIGRDML LATAGHIEDR CNRPDFLRTV LGLPPEAIDP
     EALRVKIIYG DTDSVFAAFY GIDKEALLKA VGALAANVTN ALFKEPVRLE FEKMFVSLMM
     ICKKRYIGKV HGSQNLSMKG VDLVRRTACG FVKAVVSDVL HMVFNDETVS EGTMKLSRMT
     FDDLKKNGIP CEFGPVVSRL CRARDDLHLK KVPVPELTLS SVLSQELSCY KQKNLPHLAV
     IRRLAARKEE LPAVGDRVEY VLTLPDGCKK NVPNYEIAED PRHVVEAKLS INAEKYYEQV
     VKAVTNTLMP VFPRDMPKRE KFFSLVVPQR IYIPDQFLHL CGNVNELARG GDDSDGGDSE
     KENMDTERSS SHEAMET