DPOL_NPVBM
ID DPOL_NPVBM Reviewed; 986 AA.
AC P41712; O92430;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-1998, sequence version 2.
DT 23-FEB-2022, entry version 103.
DE RecName: Full=DNA polymerase;
DE EC=2.7.7.7;
GN Name=POL;
OS Bombyx mori nuclear polyhedrosis virus (BmNPV).
OC Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX NCBI_TaxID=271108;
OH NCBI_TaxID=7091; Bombyx mori (Silk moth).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7831799; DOI=10.1016/s0042-6822(95)80059-x;
RA Chaeychomsri S., Ikeda M., Kobayashi M.;
RT "Nucleotide sequence and transcriptional analysis of the DNA polymerase
RT gene of Bombyx mori nuclear polyhedrosis virus.";
RL Virology 206:435-447(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T3;
RX PubMed=10355780; DOI=10.1099/0022-1317-80-5-1323;
RA Gomi S., Majima K., Maeda S.;
RT "Sequence analysis of the genome of Bombyx mori nucleopolyhedrovirus.";
RL J. Gen. Virol. 80:1323-1337(1999).
CC -!- FUNCTION: Replicates the viral genome, host DNA polymerases cannot
CC substitute for the viral enzyme in this process. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family. {ECO:0000305}.
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DR EMBL; D16231; BAA03756.1; -; Genomic_DNA.
DR EMBL; L33180; AAC63738.1; -; Genomic_DNA.
DR PIR; T41809; T41809.
DR RefSeq; NP_047469.1; NC_001962.1.
DR SMR; P41712; -.
DR GeneID; 1724484; -.
DR KEGG; vg:1724484; -.
DR Proteomes; UP000204315; Genome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR GO; GO:0019079; P:viral genome replication; ISS:UniProtKB.
DR Gene3D; 1.10.132.60; -; 1.
DR Gene3D; 3.30.420.10; -; 1.
DR Gene3D; 3.90.1600.10; -; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF53098; SSF53098; 1.
DR SUPFAM; SSF56672; SSF56672; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 3: Inferred from homology;
KW DNA replication; DNA-binding; DNA-directed DNA polymerase; Early protein;
KW Nucleotidyltransferase; Transferase; Viral DNA replication.
FT CHAIN 1..986
FT /note="DNA polymerase"
FT /id="PRO_0000046527"
FT REGION 804..824
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 944..969
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 807..821
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 951..965
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 116
FT /note="A -> S (in Ref. 1; BAA03756)"
FT /evidence="ECO:0000305"
FT CONFLICT 245
FT /note="H -> Y (in Ref. 1; BAA03756)"
FT /evidence="ECO:0000305"
FT CONFLICT 250
FT /note="H -> Y (in Ref. 1; BAA03756)"
FT /evidence="ECO:0000305"
FT CONFLICT 258
FT /note="V -> I (in Ref. 1; BAA03756)"
FT /evidence="ECO:0000305"
FT CONFLICT 478..479
FT /note="TA -> AG (in Ref. 1; BAA03756)"
FT /evidence="ECO:0000305"
FT CONFLICT 941
FT /note="S -> G (in Ref. 1; BAA03756)"
FT /evidence="ECO:0000305"
FT CONFLICT 952
FT /note="N -> NDN (in Ref. 1)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 986 AA; 114419 MW; 503E39F4A0BCC125 CRC64;
MKIYSYNELK TRFAEYAKPG EFSITSADTF RIIRLHYDEK QGCLFAFCNT NIEKRVLQFY
FKVKLNLYSY KQCYDKHIFP SCRNKCISYT TFVAPGVEGN CLNKINVIKY ERNKAAPSDN
AACLDKFLHN VNRVHMQTPF VEGAYMRFKK TQRCQNNYVG GSTTRMFNLQ HFYEDFELVD
EMTLTSGIMP VLSCYDIETH SDGHNMSKAS VDCIMSIGFV VYKNDEYARF CFMYHKLPTE
IPETHDDDTH VVMFQNEVDM ITAFFDMIKI TNPDVILDFN GDVFDLPYIL GRLNKTKMLL
KRYDLPAAAP TTKLFINKLG NKVDTYYFNY YIHIDLYKFF SSDSNQHKVE NFQLNTISSY
YLGENKIDLP WTEMVKMYNT RRLDVIAKYN VQDCMLPIKL FVKLKMADSV YSQCILHRLC
TDDVICNISH LISVACFYAA ITNTRINEST GKEEPDPYFF NKNDLSIISG QFNADKATAG
ISNLKRKLTP LKNIPKDAIN LGPANQTVKY KGGKVLQPRA SIYKNAFSLD FNSLYLTIMI
AICACLSNLV LCEDGNVYLN HNSRAIVVKL LLKLLSERCK FKKNRDNQSE SAFLYDLYDQ
KQNSVKRTAN SIYGYYGIFY KVLANYITRV GRNQLRRAIS LIEGLSNDPE ILKKFNLNSI
GFKVVYGDTD STFVLPTFNY NEIFDETDTL KQICTHVETR VNSSFTDGYK MAFENLMKVL
IILKKKKYCY LNSENKIVYK GWLVKKDMPV FMRIAFRTAV EQILRHLDIN KCLQSLQASF
YEYYDEFAKS KPMTDYSFSM TYNDNPGKKR KSADDNNEGP SPKRRVITVA RHCREILVNK
GTDFVPGNGD RIPYLLIDIE GKVTEKAYPL RLFDPVKMRI SWIKHMGILC TFMNELLEIF
GDEQKDNLAK CFTAIMQKYM QNQLYDRKEP VLVKINQKKC SVKRKRDDDD DNNDDDDDDG
CDSSDSENDT QCANNTYKFC LYKIKK
