ID   DPOL_NPVCF              Reviewed;         990 AA.
AC   Q90162;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=DNA polymerase;
DE            EC=2.7.7.7;
GN   Name=POL;
OS   Choristoneura fumiferana nuclear polyhedrosis virus (CfMNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=208973;
OH   NCBI_TaxID=7141; Choristoneura fumiferana (Spruce budworm moth) (Archips fumiferana).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7778286; DOI=10.1006/viro.1995.1286;
RA   Liu J.J., Carstens E.B.;
RT   "Identification, localization, transcription, and sequence analysis of the
RT   Choristoneura fumiferana nuclear polyhedrosis virus DNA polymerase gene.";
RL   Virology 209:538-549(1995).
CC   -!- FUNCTION: Replicates the viral genome, host DNA polymerases cannot
CC       substitute for the viral enzyme in this process. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family. {ECO:0000305}.
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DR   EMBL; AF512031; AAC54375.1; -; Genomic_DNA.
DR   RefSeq; NP_848372.1; NC_004778.3.
DR   SMR; Q90162; -.
DR   GeneID; 1482691; -.
DR   KEGG; vg:1482691; -.
DR   Proteomes; UP000204418; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR   GO; GO:0019079; P:viral genome replication; ISS:UniProtKB.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR042087; DNA_pol_B_thumb.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; DNA-directed DNA polymerase;
KW   Nucleotidyltransferase; Transferase; Viral DNA replication.
FT   CHAIN           1..990
FT                   /note="DNA polymerase"
FT                   /id="PRO_0000046528"
FT   REGION          936..976
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   990 AA;  114275 MW;  F95FB92AF062259C CRC64;
     MKIVTYNQLQ EAFRDYSPRD FAISRDNVFR VMRIYYNENV GQLVAFCNTQ LAGRLAQFYF
     TIKMDLYSYK QCYNSHIFAT CRNRCSSYNT FVAPGVKNVY MDKINVIKFK RNGSSFGEKA
     AALDKFLHNA NRVHMQTPVI EGTYMRFRRA QRCRNNCVTD DARPFELERF ADDFQVVNPA
     TLTTKIEPVM ACFDIETHSD GHNSSKPECD VIMCIGLAVL KDNRYDKICF VYHKELVEIS
     GNDEYTHVVV FNNESHMIAS FFDFFKYANP DVILDYNGDV FDLPYIRGRL KGDKPLLGRY
     DLPALQPNTK LFITKIGNRT DTYYFNYYIH IDLYKYFGAD ANKRDVENFE LNTLSQYYLN
     DNKVDLNWQT MVAMYNNKQL GTMIDYNLKD CLLPIRLFNK LKLNDFMYSQ CLMYRLCTDD
     FICNISHLIS STFFHLALTN TRTDPVTGLV VHDPYFFNKD DLGRMSSKDA GFCAGMSRLQ
     RKRIPLKDLP ANSIRLGAIN EIVNYEGGKV LQPRAGVYEF AFSLDFNSLY LTIMIDICAC
     LTNLILCEDG NVYLNQDKQA INVQLLLQLL KQRSELKKCR DSQTDSEFLY DLYDQMQNLS
     KRTANSIYGY YGIFCKLLAN YITRVGREKL TAAIGMIEGL SNDAELLSKF NLSTLTFRVL
     YGDTDSTFVL PTFKRDEIPE ESCMVTLTRI CAAVETRVNG LFANGYKMAF ENLMSVLILL
     KKKKYCYINS ANKIVFKGWL VKKDMPVFMR VAFRTAIEQV LRHQDLQKCL DSLLINMLMY
     FDAFGTTKPL TDYSFSMTYN DGAGKVTENE SRPTKRRVVT VARHCREILL NKGTDFVPGN
     GDRIPYVLLD IQGSVTQKAY PLRLFDPRTM RISWLKHMTI LNTFMNELLE IFGDEHTSAL
     NKCYDAILTK YMQHQAYDKK RVTLIKINAA YKRKAPSDDA ARKRARAGPS ALRKQKAASN
     DEDSSDEDDE DCSQAIGSNN TFKFSLYKYK