ID   DPOL_NPVOP              Reviewed;         985 AA.
AC   Q83948; O12554; O12843;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=DNA polymerase;
DE            EC=2.7.7.7;
GN   Name=POL; ORFNames=ORF70;
OS   Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=262177;
OH   NCBI_TaxID=33414; Orgyia pseudotsugata (Douglas-fir tussock moth).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8609478; DOI=10.1099/0022-1317-77-5-825;
RA   Ahrens C.H., Rohrmann G.F.;
RT   "The DNA polymerase and helicase genes of a baculovirus of Orgyia
RT   pseudosugata.";
RL   J. Gen. Virol. 77:825-837(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9126251; DOI=10.1006/viro.1997.8448;
RA   Ahrens C.H., Russell R.R., Funk C.J., Evans J., Harwood S., Rohrmann G.F.;
RT   "The sequence of the Orgyia pseudotsugata multinucleocapsid nuclear
RT   polyhedrosis virus genome.";
RL   Virology 229:381-399(1997).
CC   -!- FUNCTION: Replicates the viral genome, host DNA polymerases cannot
CC       substitute for the viral enzyme in this process. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family. {ECO:0000305}.
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DR   EMBL; U39145; AAB04046.1; -; Genomic_DNA.
DR   EMBL; U75930; AAC59069.1; -; Genomic_DNA.
DR   PIR; T10339; T10339.
DR   RefSeq; NP_046226.1; NC_001875.2.
DR   SMR; Q83948; -.
DR   GeneID; 912061; -.
DR   KEGG; vg:912061; -.
DR   Proteomes; UP000009248; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR   GO; GO:0019079; P:viral genome replication; ISS:UniProtKB.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR042087; DNA_pol_B_thumb.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; DNA-directed DNA polymerase; Early protein;
KW   Nucleotidyltransferase; Transferase; Viral DNA replication.
FT   CHAIN           1..985
FT                   /note="DNA polymerase"
FT                   /id="PRO_0000046530"
FT   REGION          936..972
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   985 AA;  112581 MW;  456E026E6FA73D85 CRC64;
     MKILTYNQLQ EAFRDYAPRD FAVSRDDAFR VMRIYYNEGG GNLVAFCNAQ LGGRLAQFYF
     VMKMDLYSYK PCHNSHIFAT CRNRCSSYNT FVAPGVKNVY MDKINVIKFK RNGSSFGEKT
     MALDKFLHNA NRVHMQTPVI EGTYLRFRRA QRCRNNCVAD DARPFALERF SDDFEVLDPS
     TLTTNIAPVM ACYDIETHSD GHNSSKPECD VIMCIGLAVF KNDRFEKVCF VYHSEAVEIP
     QASDDTYVVV FNNENHMITA FFEFLKTVNP DVILDYNGDV FDLPYIRGRL KGDKPLLRRY
     DLPAMQPNTK LFITKIGNRT DTYYFNYYIH IDLYKYFGVD ANKRDVENFQ LNTLSQYYLG
     DAKVDLNWQT MVEMYNNKQL GTIIKYNVQD CLLPIRLFNK LKLTDFMYSQ CIMYRLCTDD
     FICNISHLIS STFFHLALTN TRADPATGLT VSDPYFFNKD DLGLMSSKGS AGLTTGMSRL
     RRRRIPLKDV PATAIRLGAI DENVKYEGGK VLQPRAGVYE FAFSLDFNSL YLTIMIDICA
     CLTNLILCED GNVYLNQDKQ AINVQLLLQL LKQRSELKKC RDSQTESEFL YDLYDQMQNL
     SKRTANSIYG YYGIFCKLLA NHITRVGREK LTAAIGTVEG LSNDPDLLRE FGLSTLTFKV
     LYGDTDSTFV LPVFRREEIP EEGRMATLGR ICAAVEARVN GLFTNGYKMA FENLMSVLIL
     LKKKKYCYIN NNNKIVFKGW LVKKDMPVFM RVAFRAAIEQ VLRHQDLSKC LDSLKANMLM
     YLDAFGITKP LTDYSFSMTY NDGAGKTAAD DDEAAPPKRR VITVARHCRE ILVNKATDFV
     PGNGDRIPYV LLDMQGNVTQ KAYPLRLFDA QTMRISWLKH MTILNTFMNE LLEIFGDEHK
     DALAECYSAI LEKYMQHQAY DKKRAALVKI ATKRKAPSAS DASGKRARKG AAPSDDESGS
     SEDEDAPCEP KCANNTFKFC LYKAQ