ID   DPOL_OSHVF              Reviewed;        1878 AA.
AC   Q6R7C9;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   23-FEB-2022, entry version 87.
DE   RecName: Full=DNA polymerase;
DE            EC=2.7.7.7;
GN   ORFNames=ORF100;
OS   Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster
OS   herpesvirus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Malacoherpesviridae; Ostreavirus.
OX   NCBI_TaxID=654903;
OH   NCBI_TaxID=29159; Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OH   NCBI_TaxID=6579; Pecten maximus (King scallop) (Pilgrim's clam).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15604430; DOI=10.1099/vir.0.80382-0;
RA   Davison A.J., Trus B.L., Cheng N., Steven A.C., Watson M.S., Cunningham C.,
RA   Le Deuff R.M., Renault T.;
RT   "A novel class of herpesvirus with bivalve hosts.";
RL   J. Gen. Virol. 86:41-53(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family. {ECO:0000305}.
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DR   EMBL; AY509253; AAS00986.1; -; Genomic_DNA.
DR   RefSeq; YP_024639.1; NC_005881.2.
DR   GeneID; 2948204; -.
DR   KEGG; vg:2948204; -.
DR   Proteomes; UP000007021; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; DNA-directed DNA polymerase;
KW   Nucleotidyltransferase; Reference proteome; Transferase;
KW   Viral DNA replication.
FT   CHAIN           1..1878
FT                   /note="DNA polymerase"
FT                   /id="PRO_0000385022"
FT   REGION          691..727
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1839..1878
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        695..713
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1840..1863
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1878 AA;  216469 MW;  2D2C7A6088E1022A CRC64;
     MDMEIDDVDN LWTYRSVCMP DYKDAAEIIR PEFDMTKRIF NQRKHLLGMD GHCSTGMTMN
     EFGTRPMVFT VSKGCYPDLP TDKDKFVGDP QGPKELYMHV YGRFDTYYLD LQNEFQDINN
     VMNTTHDYNI YDLLKTGART AMVREAFAGA NIHGWLGTKL VYKRPPQSSA GGCRFMVKVY
     IAGQKTASAY QIKNTLNATS NRFRKKVYNS CVQTYTDFLV AKNAGPIGEM RIKKGVNPGV
     KKGAKYDYVD VHYRDIEFSN YDTFVLSEID GVGEDLINLA TSILNNHRNN FDILTKTFIK
     SRLKSLAPII GGLIGSPNDF TKFKKKMVMY IMTKEFKNCM EYYLTELRSK GIQLYHALGI
     KSEDVKEEYV RTFCVNMLRY QYLLVMSLKE FWVEKVRGKL YSAVMAKEKE MLTQKIGMQL
     RTMCFDIETN FVPHSDAEQQ VTLIHCVLYD EGAHNCPIEQ RTFHYKAEER SMESLKTDLT
     YDKVVELCKK QVRDGYDLKM KEWLTRTVEQ TGMFKSKKIL SLFFEKMMTE SKIKIHPDSH
     DYDADNSEPK SVEECLAFCK KRIIEVFDIC MEPGKNYFIY NFKTEKEMLL AFLKYVRDSN
     LTVLTHYNGD SFDLPFVINR CEKLKIDGMK EYTPATFSDG STETKRRRFQ LKLTHRHDIL
     TIKYKKSGKV ADSTHKKNAI NSYLESKREK LFQADDDDDD DDEDEDDGLL DERQQDSAED
     MKKKGPNVYR PMAEARNIFT LQSNFVASRD VMKMVPDQAP NVDDKILKDK TLNSSAFSFL
     GIRKIDHEAV SYANLCKTWK FGDLNIFVAY CAVDTLLTMK IDQTLKTGMN AVATASNVYL
     PIRELYGNQA LVRTLAIMYS YQWYKNICSP DPSVFKNEDR FWNPEYVWKD DDFKDLKPRA
     GRTISNVSGV YNSFFSVLFD FNSQYPGVMI SENVCVSTLL DKEDADKMSK DDYVEMTIPN
     VYPKVRHACE PGSEKCGMNL EVVKKKKDYG LKCKWTQEFV MCEHIAKFAK KSVMEGIAGE
     CCKNLLAKRK HYKKLMAEAA KGGNHTEVVI YNQLQLVMKV NANSIFGILL LLDSVTGGAI
     THEARMQNER GSEYLKKVSG PMAMADTDST APIAENLPLD WQPGDDKDDV GPLNRLCRRL
     FPGRKRPKIS EFVHKIDTMY ESYGSYLNDG VPEKGIPPAW IKPANLEIEK MFIGLVFIKK
     KNYYALKMLP GGELATHVAG LACMKSDKTK IKGATQLVLL KMLVEGDYEG YIRYATDLFS
     LMVVTLRAEE ASKSAVKMAV ENGQLEGLDE LEEKTKRDFG YRDLIPKVYY TSREKVNSIE
     NPKTVADKME QLRCKRYGID FSIAATVTDV VRGIKPQVGA PLTAINNTIL IREPTEEQKT
     IEREMDMRWM ARSFRQQTRE DNRLSDKKEK IKKKNAEVKP LDITDMPDRL KVDQQVHTTP
     FPTRIRLGVK KLNNMIDYSE KAITKERDSD FVKELFHQPE LMADEEELQR ATEQVVEMIE
     NFKSFSLHFP LFWYDERYCI SNILELEDLD EVWHTLPNDE SCVDLWNMYK NLEYEPRYIA
     VKVGKMGERL QMAFFDSVEE SWMEYKCTNC YIFKENVWSL DDKNLAGKIY YMDMQEYEKQ
     TRTTPLIITS PDKKKRYLVN RGSYVRNKNN AFSFKIKNET LMNAMSQTGD VGDKYLTFKP
     IYGKAGVCII GSKSAGMCKS TFIRDDGREM PATWPYKRLN NQGIKIPRQK LLKIMNDSLE
     IRNIHNNHNL EFSFDSKTKN LTIRVETAFD EKRIKFYDES KQEKLEIDIG TNGQTQLGSF
     YTSVRIENKV EKKPKEVLPE KKQSTLSHFV GMSSAPKFTQ DDVVKKKRAP KRAAIDRKSG
     SGGKKSKITA GKTAGTMF