ID   DPOL_POV01              Reviewed;        1206 AA.
AC   A7U6F2;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   23-FEB-2022, entry version 56.
DE   RecName: Full=DNA polymerase;
DE            EC=2.7.7.7;
GN   Name=dpo;
OS   Pyramimonas orientalis virus (PoV01).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Algavirales; Phycodnaviridae; unclassified Phycodnaviridae.
OX   NCBI_TaxID=455367;
OH   NCBI_TaxID=36893; Pyramimonas plurioculata.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=18359826; DOI=10.1128/aem.02548-07;
RA   Larsen J.B., Larsen A., Bratbak G., Sandaa R.A.;
RT   "Phylogenetic analysis of members of the Phycodnaviridae virus family,
RT   using amplified fragments of the major capsid protein gene.";
RL   Appl. Environ. Microbiol. 74:3048-3057(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family. {ECO:0000305}.
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DR   EMBL; EU006633; ABU23717.1; -; Genomic_DNA.
DR   SMR; A7U6F2; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR042087; DNA_pol_B_thumb.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 2.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; DNA-directed DNA polymerase;
KW   Nucleotidyltransferase; Transferase; Viral DNA replication.
FT   CHAIN           1..1206
FT                   /note="DNA polymerase"
FT                   /id="PRO_0000338008"
SQ   SEQUENCE   1206 AA;  138160 MW;  16DF85F71CB7C54D CRC64;
     MNFRDHSISL DESKNACFQV IDWYHFDYTN EDSNESQYII KMFGVTEEGY SLCVNVTDFQ
     PHFYISSKTK DKFTQTELDD LEEYIINKLP YNFKNSLSVK QVRKKSIWGF TNNVYKQYIK
     LSFQNIMSMY ITRKMLQYRI KVGRVQVQFD LNESNIDPFL RFIHIQNIKP GGWISIDEYT
     TDVDDELESK CQINITTSCE NVQPLDCNKV APVNIMSFDI ECTSSSGDFP VPIKTYKKTA
     EEISDLYNSF KSDSHHDGFI PALYKCFMGI YTDEKEFMND CGTYCNKNLL ECNTNNIKFA
     KVYPKKKKID LETIFQKLQG YTDTIVDILK NRSKHTVFQE ENDGLEPSVV NQLEVLLNSF
     LPPLKGDPII QIGSTIHQYG STKCSYKNVI TLDTCNDIPG VDVITCKTET ALIKEWCKLI
     HRVDPDIMTG YNIFGFDFDY IYKRALELGC EKYVLGCSRL EGHKSKFKEK MLASSALGEN
     LLKYVEMEGR VFVDLMKVVQ REYNLDSYKL DNVASHFISG KVKTHNKTTL HLDSAAGINV
     GDYIKLNNTY KCMVLSVDSN IIVIDTELDE KIVTWGLAKD DVSPKEIFAC QKGTSADRAK
     IAKYCVQDCA LCNMLIIKLE VFANNMGMAN VCLVPLSYIF MRGQGIKIFS LVAKQCRDDN
     FIIPLIKFDQ DSEEVEGYEG AIVLDPIPGI YVEAPISVMD YASLYPSSMI SENISHDSIV
     LDKKYDNLPG VEYVDVTYDI FTGVGDKKTK VDEKTCRYAQ FKNNEKGVLP RILMKLLSQR
     KSTRKQILHK TVTTNDNRSF TGLVDENDDS VTIKTTDNNT ITLSRNEILS SVDTYNDFMK
     AILDGLQLAY KITANSLYGQ VGARTSPIYM KELAASTTAT GRNLIMKAKE FMETNYGADV
     VYGDTDSIFV DFKVKEKYGL LDKDALQKSI DISVKASDAF KKELKAPHDL EYEKTFFPFI
     ILSKKKYVGN LYEHDVNKYK QKSMGIVLKR RDNANIVKIV YGGIIDILLN RQNISFAINF
     LKESLRKLVN GEFHMDDLVI TKTLRTTYKD PTRIAHKVLA DRMRNRDPGS APQSSDRVPY
     AYIEHDIKNK SLLQGDKIEH PSYIKENNVK IDYIFYITNQ LMKPICQLMA LALFQIPKSS
     KPEIYERKLK SLTLDYEGNK KRAIDKVSDL KQKEIQKLLF DETLVHLNNK RMGNREILEF
     FSVTPV