ID   DPOL_PPV01              Reviewed;        1045 AA.
AC   A7U6F3;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   23-FEB-2022, entry version 58.
DE   RecName: Full=DNA polymerase;
DE            EC=2.7.7.7;
GN   Name=dpo;
OS   Phaeocystis pouchetii virus (PpV01).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Algavirales; Phycodnaviridae; unclassified Phycodnaviridae.
OX   NCBI_TaxID=455365;
OH   NCBI_TaxID=33659; Phaeocystis pouchetii.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=18359826; DOI=10.1128/aem.02548-07;
RA   Larsen J.B., Larsen A., Bratbak G., Sandaa R.A.;
RT   "Phylogenetic analysis of members of the Phycodnaviridae virus family,
RT   using amplified fragments of the major capsid protein gene.";
RL   Appl. Environ. Microbiol. 74:3048-3057(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family. {ECO:0000305}.
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DR   EMBL; EU006634; ABU23718.1; -; Genomic_DNA.
DR   PRIDE; A7U6F3; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 2.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; DNA-directed DNA polymerase;
KW   Nucleotidyltransferase; Transferase; Viral DNA replication.
FT   CHAIN           1..1045
FT                   /note="DNA polymerase"
FT                   /id="PRO_0000338009"
FT   REGION          331..355
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        336..352
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1045 AA;  120261 MW;  8E8E9042CF17C1D5 CRC64;
     MTTKTVIKTK SYKLYDFNVY DGFSKAENLG KNGYDKFKDN KKFIIQMFGI NTAGQTASII
     VEDFNPFYYI KVGDDWTESD RCEFVSHIKG KLGVYYEDSI VASKLVKRHK LYGFDDNKLH
     TFIKISFTNT GAYNRAKKMF YIDSNVDGVF KRELLPDGYL YEETKCYLYE ANIPPLLKLF
     HIQEISPSGW VQIQTDKITK MRQKSTHCAY EYITSYKHLK KADKDDIVKY SICSFDIEAS
     SSHGDFPVPI KDYKKLATNI LEYYNEMEDK TKFDVTCFKK HINAGYGYER CPDIATVYPK
     LKNISNEQLD NIFSNFMLYI PAKDQSRKDY IKENEESDSE SDNDDEEDKK ENDGADEAAA
     FHKRHKKVKK YNKTANILQI IQDDKCEHDT KLFELNKALT KFYPELEGDM VTFIGMTFLN
     YSDKKPHTRY IIVKGGCEVP EKYKSWVLEN NVKIIEKTTE KGVLLEFTKI MTLENPHIVT
     GYNINGFDFD FMFKRSKEIG CTEDFLKLSK NIDEVCMTKD WKTGEMEIAK NKIVLASGEY
     NLSFVNMPGR IIVDMCVVFR REYTLSSNKL DYVSSYFISD SVKKIDVDKE NNQTRIYSKN
     LTGLTVGCYV KFDEVSHSTN NYKKGQKFEI LDINLDTASF LIDSAEELDL KKYKINWGLA
     KDDVSVQEIF ELANKSDIDR FTVGKYCLGD CDNVIWLLIK VDIITDKVEM SNLCDVPLNF
     LLQRGQGIKL QSYVSKKCGE KNTLMPIVEK NLNDGGYEGA HVFNPKTGLY LEDPVACVDY
     SSLYPSSMIS ENLSHDSKVW TKEYDLSNNL IHSTGEKDAD ENFIYDNLPN YTYVDVKYDT
     YEYLRKTPKA AEKKTVVGYK ICRFAQFPKG KAIMPAILED LLSARKATKK LMGKEEDPFK
     QNIYDKRQLS IKVTANSLYG QCGARTSAFY EKDVAASCTA IGRKLLFYGK DVIEGCYNNV
     EITLSDGVKV VTKAECVYGD TDSVFFKFNL KTPEGKRIIN KQALIYTIEL AKQAGELATK
     FLKKPTRFRV RENILAFQSI IQEKI