ID   DPOL_RCMVM              Reviewed;        1173 AA.
AC   Q85428;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2001, sequence version 2.
DT   29-SEP-2021, entry version 102.
DE   RecName: Full=DNA polymerase catalytic subunit;
DE            EC=2.7.7.7;
GN   Name=UL54;
OS   Rat cytomegalovirus (strain Maastricht).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Muromegalovirus.
OX   NCBI_TaxID=79700;
OH   NCBI_TaxID=10114; Rattus.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8757999; DOI=10.1099/0022-1317-77-7-1559;
RA   Beuken E., Slobbe R., Bruggeman C.A., Vink C.;
RT   "Cloning and sequence analysis of the genes encoding DNA polymerase,
RT   glycoprotein B, ICP18.5 and major DNA-binding protein of rat
RT   cytomegalovirus.";
RL   J. Gen. Virol. 77:1559-1562(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SEQUENCE REVISION.
RX   PubMed=10906222; DOI=10.1128/jvi.74.16.7656-7665.2000;
RA   Vink C., Beuken E., Bruggeman C.A.;
RT   "Complete DNA sequence of the rat cytomegalovirus genome.";
RL   J. Virol. 74:7656-7665(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SUBCELLULAR LOCATION: Host nucleus.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family. {ECO:0000305}.
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DR   EMBL; AF232689; AAF99153.1; -; Genomic_DNA.
DR   RefSeq; NP_064160.1; NC_002512.2.
DR   SMR; Q85428; -.
DR   PRIDE; Q85428; -.
DR   GeneID; 940420; -.
DR   KEGG; vg:940420; -.
DR   Proteomes; UP000008288; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR042087; DNA_pol_B_thumb.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; DNA-directed DNA polymerase; Host nucleus;
KW   Nucleotidyltransferase; Reference proteome; Transferase;
KW   Viral DNA replication.
FT   CHAIN           1..1173
FT                   /note="DNA polymerase catalytic subunit"
FT                   /id="PRO_0000046509"
FT   REGION          554..625
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1123..1144
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        576..591
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1173 AA;  130496 MW;  900199F268F95DC3 CRC64;
     MDAEIFFNPY LHTKRSRRDW RAEPAADNKE SFLQIVPRGV LYDGATGLIK TQCELSPRMF
     FEDREYVLDP VMVWPGLDIA ADGEAVPPCD FVFHTFDQVV SLVFAEGRGR ARRWRQHISP
     AGNVIRLFGA TALGTPVCVN VFGQKSYFYC ENRPGEDLRD VIHDLADASR SPGPLSASPS
     RRAPLVAVRL RPGDIPHLYR VSFNNWSMAR KVGALMVQEG RRAYEIGVDP LARFLIDRKI
     PSFGWLRVGR FSRRCNGQTS TAVIELDCQV GDVVAGQPLP NWPPYRCLSF DIECMSASGA
     FPQAEVLDDI VIQISCVCFV VGGSGAHRFT FAEKHLFTIG SCAPVEDVWV YTFPSEYEML
     LGFFIFFNRF SPDFLTGYNI NGFDIKYLLH RMCRVYQKDA GRFTKLRRGG RFFVNSPDGS
     GDAFGGRSGV IKVFCAGTVV LDMYPVCSAK TSAPNYKLDT MAERYLGQRK EDLSYKEIPV
     AFLGGEEGRA RVGKYCVQDG ARQGPLNVIA YHYEAAASPN LARIPLRRVI FDGQQIRIYT
     CILEECSARG MVLPSLPSSP PSSGGDGAGL EGGDGGTAGR RKKKRSGSAP DGEDEDDPEG
     GDEGENGECR ENGLEKEGSQ GSASGNVGYQ GATVLAPECG YHHNPILVFD FASLYPSIIM
     SNNLCYSTLL VDGSPPVPDE DVLEVVVGEA TRYRFVREHV RRSLLAELLV RWLKQRKLVR
     DAMKACGDEK QRMFMDKQQL ALKVTCNAFY GFTGVAAPML PCLPIAASIT KIGRDMLLAT
     SAYMERHCND VEFLVSEVGV PREAVDRDAL RVKIVYGDTD SVFVGFRGIG REVLVKVAGK
     LAAAVTRDLF RDPVRLEFEK MFVSLMMICK KRYIGKVYGE NKLCMKGVDL VRRHACAFVR
     SIVSEVVDVI FHDEAVSEGA MRLSEMSFEE LRRQGVPVGF FPVIRRLCDA RDDLFLDRVP
     VAQLVLSSVL SQDASRYKQK NLPHLAVYRS LVERGEELPG VGDRIEYVLT CPDESKKRAP
     NYEVAEDPAH VREAKIPIHA EKYFDQIVKA VTNVLLPVFP KDMPRRERFF AYVLPIRTYL
     PEVFLRMSKE DRECGAYLAR ESGLGMNSFI VYGEDTCGSR VGEGPGRGEG LGVGGGEGTR
     PPRKNGHARL VSGCLYGSRP FNKKDRFVTL HIE