ID   DPOL_RHCM6              Reviewed;        1035 AA.
AC   O71121;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   29-SEP-2021, entry version 90.
DE   RecName: Full=DNA polymerase catalytic subunit;
DE            EC=2.7.7.7;
GN   Name=UL54;
OS   Rhesus cytomegalovirus (strain 68-1) (RhCMV).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=103930;
OH   NCBI_TaxID=9544; Macaca mulatta (Rhesus macaque).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9454707; DOI=10.1006/viro.1997.8935;
RA   Swanson R., Bergquam E., Wong S.W.;
RT   "Characterization of rhesus cytomegalovirus genes associated with anti-
RT   viral susceptibility.";
RL   Virology 240:338-348(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SUBCELLULAR LOCATION: Host nucleus.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family. {ECO:0000305}.
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DR   EMBL; AF033184; AAC05256.1; -; Genomic_DNA.
DR   RefSeq; YP_068180.1; NC_006150.1.
DR   SMR; O71121; -.
DR   PRIDE; O71121; -.
DR   GeneID; 2952813; -.
DR   KEGG; vg:2952813; -.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR042087; DNA_pol_B_thumb.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; DNA-directed DNA polymerase; Host nucleus;
KW   Nucleotidyltransferase; Transferase; Viral DNA replication.
FT   CHAIN           1..1035
FT                   /note="DNA polymerase catalytic subunit"
FT                   /id="PRO_0000046510"
SQ   SEQUENCE   1035 AA;  116595 MW;  4E320D2F062D90C1 CRC64;
     MFFNPYLSGA RKPPNLVAKR SVAKTFLEIV PRGAMHDGQS GLIKHKTGRG AIMFYRDIKH
     VLENDMAWPC PLPAPPPSIE AFARRLMGPL KFHTYDQVDG VLTHDTQECL SPRYRHHITP
     SGNVLRFFGA TEQGHSICVN VFGQRSYFYC EYADGDLLRD LLASVSDLVS EPRMAYALTI
     TPVQKMSIYG YGTSPIPNLF RVSISNWSMA KKIGEYLLEN GIPVYEIRVD PLTRLVIDKK
     MTTFGWCCVH RYEWRTHKSS TCDFEIDCDV ADIMAVSDDT SWPVYRCLSF DIECMSASGG
     FPAAEQTDDI VIQISCVCYN TGGTGCEENT VFGTSGLHLF TIGSCAPLAG VDVYEFPSEY
     EMLLGFLIFF QRYSPCFVTG YNINSFDFKY ILTRLEFVYK LSPGPYSKLP AQGRFSMYSP
     LKKFVTTTTT KVFISGTVVI DMYPVCMAKT SSPNYKLNTM AELYLKQQKE DMSYKDIPVK
     FISGCEGRAQ VGKYCVQDAV LVKDLFNTIN FHYEAGAIAR LARIPMRRVI FDGQQIRIYT
     SLLDECACRD FIMPNHKGAD NSSEPTDVSY QGATVFEPEV GYYSDPVVVF DFASLYPSII
     MAHNLCYSTF VAPGGESPPE SDVLTVELES GLSYRFVKNT VRNSVLSELL TKWVSQRRAV
     RETMRSCHDP VKRMLLDKEQ LALKVTCNAF YGFTGVVNGM MPCLPIAASI TRIGRDMLMR
     TSQFVEENFA EPCFLHNFFN REDYSGDPVA VKVIYGDTDS VFVCYRGVTA AALIERGPSL
     AHYITQCLFV DPIKLEFEKV FGSLMMICKK RYIGKIVGET ELSMKGVDLV RKTSCEFVKN
     VTRDIIQLLF DDPEVSRAAV QLSRLTLDEL KMQGVPPGFG RVIQRLSQAR DELYTSRARV
     EELVLSSVLS KDVSLYKQSN LPHIAVIKRL AARSEELPVV GDRVFYVLTA PVDGRSSGVR
     NYEIAEDPTY VREHGVPIHA DKYFDQVIKS VTNVLSPVFP PQTLRKDKFL LGILPHRIYL
     EPSFLPYCVK ASEHC