ID   DPOL_RSIV               Reviewed;         947 AA.
AC   O70736;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   23-FEB-2022, entry version 84.
DE   RecName: Full=DNA polymerase;
DE            EC=2.7.7.7;
OS   Red sea bream iridovirus (RSIV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Pimascovirales; Iridoviridae; Alphairidovirinae; Megalocytivirus;
OC   Infectious spleen and kidney necrosis virus.
OX   NCBI_TaxID=65424;
OH   NCBI_TaxID=94231; Epinephelus.
OH   NCBI_TaxID=8163; Lateolabrax.
OH   NCBI_TaxID=8160; Seriola.
OH   NCBI_TaxID=8237; Thunnus thynnus (Atlantic bluefin tuna) (Scomber thynnus).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Ehime-1;
RA   Kurita J., Nakajima K., Hirono I., Aoki T.;
RT   "Polymerase chain reaction (PCR) amplification of DNA of red sea bream
RT   iridovirus (RSIV).";
RL   Fish Pathol. 33:17-23(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family. {ECO:0000305}.
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DR   EMBL; AB007366; BAA28669.1; -; Genomic_DNA.
DR   SMR; O70736; -.
DR   PRIDE; O70736; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR042087; DNA_pol_B_thumb.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; DNA-directed DNA polymerase;
KW   Nucleotidyltransferase; Transferase; Viral DNA replication.
FT   CHAIN           1..947
FT                   /note="DNA polymerase"
FT                   /id="PRO_0000046504"
SQ   SEQUENCE   947 AA;  107025 MW;  8C5EF4C31AB33195 CRC64;
     MDSVYIYQWL YANYEVRGYG IALNNTVVCV RVPNFKQVVY VECTDPQHDP RSTFTQHGFR
     VYETPRACSL YGAKGVGTYF AARVPNYNAM RDVQETQGPF KIHESRVSKT MEFTARAGLP
     TVGWIQVSQR CVVTRTVTMA AKEYMVPNWR TDVRPAPDIE GVPPAKIVYF DIEVKSDHEN
     VFPSDRDDEV IFQIGLVLCS GTTVLRTDLL SLPGRDYDAS VYQYATEGEL LHAFIAYIRE
     HEVVAVCGYN IMGFDIPYII KRCARTSMLG TFKRIGWDSH RLAIEKTAGV GHAKMTYIQW
     EGVLTIDLMP IIMMDHKLDS YSLDYVANHF VKAGKDPIRP RDIFHAYNTG LMARVGRYCV
     KDTQLCKQLV DYLNTWVALC EMAGVCNTSI MQLFTQGQQV RVFAQIYRDC TPMDVVDKVY
     VIPDGGCDSD VVSPSSYTGA YVYEPVPGVY KNVIPMDFQS LYPSIIISKN ICYSTLVDQG
     GEEYAWQEHE GCEHDPQYAK QHALGVEIGV LQCNMAALPR RATQERARMR ERISEMKIQY
     ASMTPSVVKC NVFSFRFTHA HEGVLPRVLR NLLESRARVR ARIKTTDDPD IRAVLDKKQL
     AYKISANSVY GTMGTQRGYL PFMAGAMTTT YCGRKLIEKA AHLLKTVVGA TIVYGDTDSC
     YIQLGHDRAS LDELWQMAVN ASDTVSAFFE RPVRLEFEQC IYTKFIIFTK KRYVYRAFTR
     DGKQRTGSKG VMLSRRDSAM CARNTYAAIM SAILEGSADV PFIAVRMMHD MMIPGALQDD
     DFVLTKSVQD IGNGDDNNHG SYKVRNPQKA QAAATQRVAP DDAEGYAIAL RQEMVKQMPA
     QAQLAERMRL QGRAVVSGAR IEYVVLKHQY GVPEGALGAR LLDFERWRDM KVAYPLDRLY
     YMKSVVNACD QLLVTAGYGP VCSKVYAAHL QLAYVHKQLM RRMMPTV