ID   DPOL_SFAVA              Reviewed;        1104 AA.
AC   Q779J8; Q0E5A0; Q86992;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   23-FEB-2022, entry version 90.
DE   RecName: Full=DNA polymerase;
DE            EC=2.7.7.7;
GN   ORFNames=ORF1;
OS   Spodoptera frugiperda ascovirus 1a (SfAV-1a).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Pimascovirales; Ascoviridae; Ascovirus.
OX   NCBI_TaxID=113370;
OH   NCBI_TaxID=7108; Spodoptera frugiperda (Fall armyworm).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=8614981; DOI=10.1006/viro.1996.0041;
RA   Pellock B.J., Lu A., Meagher R.B., Weise M.J., Miller L.K.;
RT   "Sequence, function, and phylogenetic analysis of an ascovirus DNA
RT   polymerase gene.";
RL   Virology 216:146-157(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11086137; DOI=10.1099/0022-1317-81-12-3059;
RA   Stasiak K., Demattei M.V., Federici B.A., Bigot Y.;
RT   "Phylogenetic position of the Diadromus pulchellus ascovirus DNA polymerase
RT   among viruses with large double-stranded DNA genomes.";
RL   J. Gen. Virol. 81:3059-3072(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16987980; DOI=10.1128/jvi.01639-06;
RA   Bideshi D.K., Demattei M.V., Rouleux-Bonnin F., Stasiak K., Tan Y.,
RA   Bigot S., Bigot Y., Federici B.A.;
RT   "Genomic sequence of Spodoptera frugiperda Ascovirus 1a, an enveloped,
RT   double-stranded DNA insect virus that manipulates apoptosis for viral
RT   reproduction.";
RL   J. Virol. 80:11791-11805(2006).
CC   -!- FUNCTION: Replicates the viral genome. Host DNA polymerases cannot
CC       substitute for the viral enzyme in this process.
CC       {ECO:0000269|PubMed:8614981}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U35732; AAC54632.1; -; Genomic_DNA.
DR   EMBL; AJ279828; CAC19170.1; -; Genomic_DNA.
DR   EMBL; AM398843; CAL44601.1; -; Genomic_DNA.
DR   RefSeq; YP_762356.1; NC_008361.1.
DR   SMR; Q779J8; -.
DR   PRIDE; Q779J8; -.
DR   GeneID; 4306168; -.
DR   KEGG; vg:4306168; -.
DR   Proteomes; UP000008030; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR042087; DNA_pol_B_thumb.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00136; DNA_pol_B; 2.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; DNA-directed DNA polymerase;
KW   Nucleotidyltransferase; Reference proteome; Transferase;
KW   Viral DNA replication.
FT   CHAIN           1..1104
FT                   /note="DNA polymerase"
FT                   /id="PRO_0000329071"
SQ   SEQUENCE   1104 AA;  125787 MW;  3E609827CEF3E40B CRC64;
     MLLKMSAFTA RSSDNFYVYD WRVVSTEKEN SYTDRNGVRR QWKDITLMLR AYCVDEKGAT
     ACLRLGQVKT KLYCEFPDDY PLERGGAVWR SVRAKLKEAI TCKHDQDESN VQLVDMQPLY
     GVGKATKTFV AISFTSEVGK RAFVNRVCGR HRKPPSAALK FPNNLSGERI RFHWINVPTE
     LQVLVQHKLP FAGWVETGRL YEPRSRLTRC DREYCTDLPA LKSSELLACV APSLKTFAWD
     IEAKINDMSM PGYHVDDEVY MVSIAVSDGT DHLIITAPGE CERDLVDALR KDKDIDNLNV
     HVCRDEVSLL LKFNQVTRSI GAVARMGWNV NRFDCVVMMA RATQLNCVNT LLDMGFAKDV
     PGQVSTTAGR TYGKISPSEP IYFDTHGVLC LDVMEMFRST YTKLPKYSLQ YVSGKFLNAS
     KDPVTLKDLN ELHSRLMERS ADVDRLRAVV SKYCIRDSRL TLALCNKCAH ITSLTEMARI
     TNTPIVMVHY QKQQRRMFHL MFSECMRENV AMQDDFGLAN AAPFETVAAT QKKQLSYSGA
     YVKDPEPGLY SMVGSLDVNN MYPTLMIAYN LCYSTVVDEH SPSAFTDDHF EYIRWEDHVG
     CEHDPVQVEL KSLRSMFEMK ALTDKRKRIG VTAITKYFKP IQGPRIIQKI MDDRYAESTC
     RYDDGDEFCE NDDEKEVIAA IKTPLEMQRA AIRLKVLKSR ASGGSVLCAK QCVKILKTRR
     GILPDLVECL LQARKRVRGN MKSVTDPMAR DILDKSQLAY KVTANSIYGS TGASNGKLPC
     QNVAKVTTAL GRMTILQAIE IARTERNVTT IYSDTDSMYV QLQDDPASNQ DPWTYVRELA
     THITSKLREP MVIEAEDDIH AKVLFLGKKC YIGRKLFRDG SVARDLDWHV VITVRRDHSE
     YVKSAYKPPV YKVFADCTHD QFVTSIAESC LRLMRRTVPC EMLTKTSEVR NLGDGCQLVL
     CKKTMSWMWG DYKVARHEQH DRLQRENPKW LRDYYVSKLP APARLSILLT DRARPPVEGG
     RIEFLNVKTE TKSALAIEEI SYFKDNPGCA QVDNMYYIQQ LVNPLTKVSE AVWRRSNSVN
     IAIAPFIYYN KVLAQLSTRF KISQ