ID   DPOL_SHV21              Reviewed;        1009 AA.
AC   P24907;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   29-SEP-2021, entry version 105.
DE   RecName: Full=DNA polymerase catalytic subunit;
DE            EC=2.7.7.7;
GN   Name=9; Synonyms=KCRF2;
OS   Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.
OX   NCBI_TaxID=10383;
OH   NCBI_TaxID=9521; Saimiri sciureus (Common squirrel monkey).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2154888; DOI=10.1016/0042-6822(90)90107-3;
RA   Albrecht J.-C., Fleckenstein B.;
RT   "Structural organization of the conserved gene block of Herpesvirus saimiri
RT   coding for DNA polymerase, glycoprotein B, and major DNA binding protein.";
RL   Virology 174:533-542(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=1321287; DOI=10.1128/jvi.66.8.5047-5058.1992;
RA   Albrecht J.-C., Nicholas J., Biller D., Cameron K.R., Biesinger B.,
RA   Newman C., Wittmann S., Craxton M.A., Coleman H., Fleckenstein B.,
RA   Honess R.W.;
RT   "Primary structure of the herpesvirus saimiri genome.";
RL   J. Virol. 66:5047-5058(1992).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SUBCELLULAR LOCATION: Host nucleus.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family. {ECO:0000305}.
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DR   EMBL; X64346; CAA45632.1; -; Genomic_DNA.
DR   EMBL; M31122; AAA46165.1; -; Genomic_DNA.
DR   RefSeq; NP_040211.1; NC_001350.1.
DR   SMR; P24907; -.
DR   PRIDE; P24907; -.
DR   GeneID; 1682519; -.
DR   KEGG; vg:1682519; -.
DR   Proteomes; UP000000587; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR042087; DNA_pol_B_thumb.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; DNA-directed DNA polymerase; Host nucleus;
KW   Nucleotidyltransferase; Reference proteome; Transferase;
KW   Viral DNA replication.
FT   CHAIN           1..1009
FT                   /note="DNA polymerase catalytic subunit"
FT                   /id="PRO_0000046522"
SQ   SEQUENCE   1009 AA;  113935 MW;  AB924C0DF0D95B28 CRC64;
     MDFYNPYLSK KPTDTKTPKL HTTRQSICRL VPKCFRNPTE KGVVSVSSFA LPTYFFKGNE
     NKVYLENGKS MWHLRRPCKN ALLEEQSITF HIYDIVETTY SEDRCNDIPF KFQTDIIPNG
     TVLKLLGRTL EGASVCVNVF GQRNYFYVKV PEGGNITYLI KQALNEKFSP SCAYQTEAVK
     KKILSRYDPE EHDVFKVTVS SSLSVYKISD SLVSNGCEVF ETNVDAIRRF VIDNDFSTFG
     WYTCKSACPR ITNRDSHTDI EFDCGYYDLE FHADRTEWPP YNIMSFDIEC IGEKGFPCAK
     NEGDLIIQIS CVFWHAGALD TTRNMLLSLG TCSAVENTEV YEFPSEIDML HGFFSLIRDF
     NVEIITGYNI SNFDLPYLID RATQIYNIKL SDYSRVKTGS IFQVHTPKDT GNGFMRSVSK
     IKISGIIAID MYIVCKDKLS LSNYKLDTVA NHCIGAKKED VSYKDIMPLF MSGPEGRAKI
     GLYCVIDSVL VMKLLKFFMI HVEISEIAKL AKIPTRRVLT DGQQIRVFSC LLAAARAENY
     ILPVSNDVNA DGFQGATVIN PIPGFYNNAV LVVDFASLYP SIIQAHNLCY STLIPHHALH
     NYPHLKSSDY ETFMLSSGPI HFVKKHIQAS LLSRLLTVWL SKRKAIRQKL AECEDLDTKT
     ILDKQQLAIK VTCNAVYGFT GVASGLLPCI SIAETVTLQG RTMLEKSKIF IEAMTPDTLQ
     EIVPHIVKHE PDAKFRVIYG DTDSLFVECV GYSVDTVVKF GDFLAAFTSE KLFNAPIKLE
     SEKTFQCLLL LAKKRYIGIL SNDKLLMKGV DLVRKTACKF VQNTSSKILN LILKDPEVKA
     AAQLLSTKDP DYAFREGLPD GFLKVIDILN ESHKNLRTGQ VPVEELTFST ELSRPISSYK
     TENLPHLTVY KKIITRHEEP PQVHDRIPYV FVGKTTSCIS NMAEDPTYTV QNNIPIAVDL
     YFDKLIHGVA NIIQCLFKDS SKTVSVLYNF VSTPVLFSYE LLTDHSVKA