ID   DPOL_TNAVC              Reviewed;        1025 AA.
AC   Q4U3V0;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 2.
DT   23-FEB-2022, entry version 73.
DE   RecName: Full=DNA polymerase;
DE            EC=2.7.7.7;
GN   ORFNames=ORF1;
OS   Trichoplusia ni ascovirus 2c (TnAV-2c).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Pimascovirales; Ascoviridae; Ascovirus.
OX   NCBI_TaxID=328615;
OH   NCBI_TaxID=7100; Noctuidae (owlet moths).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16876847; DOI=10.1016/j.virol.2006.06.029;
RA   Wang L., Xue J., Seaborn C.P., Arif B.M., Cheng X.W.;
RT   "Sequence and organization of the Trichoplusia ni ascovirus 2c
RT   (Ascoviridae) genome.";
RL   Virology 354:167-177(2006).
CC   -!- FUNCTION: Replicates the viral genome. Host DNA polymerases cannot
CC       substitute for the viral enzyme in this process (By similarity).
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family. {ECO:0000305}.
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DR   EMBL; DQ517337; AAY43137.2; -; Genomic_DNA.
DR   RefSeq; YP_803224.1; NC_008518.1.
DR   SMR; Q4U3V0; -.
DR   GeneID; 5141757; -.
DR   KEGG; vg:5141757; -.
DR   Proteomes; UP000001323; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR042087; DNA_pol_B_thumb.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00136; DNA_pol_B; 2.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; DNA-directed DNA polymerase;
KW   Nucleotidyltransferase; Reference proteome; Transferase;
KW   Viral DNA replication.
FT   CHAIN           1..1025
FT                   /note="DNA polymerase"
FT                   /id="PRO_0000329072"
SQ   SEQUENCE   1025 AA;  117114 MW;  52D0690AB8A27E34 CRC64;
     MNKEHLTIYA YDWRVNSVER EIYHTSDRKS KDFELHLRVY GVNERGETTC VLMNKVTTSI
     LLEFPDNYDV ETNWSRVRME LMSAIFCSTD KTDKNVVMVK KQPLYGARHD KYFCKVSFSS
     DIGKRAFVMR VNGTVDRGSA ATANRKGGKI HQPMKFPNGL TGDMIKIHGI DVPTELQVLE
     ELDIPPCGWI ETHNAYKCAT ITKRFTHQYR ANVKTFKYCT RMECIPPVLK TMAWDIEARI
     HDISSPGLHI DDEIYMMSVS VSDGKDYLLT LGPVSNEDKI RFDEDTDIKV YQTEERLLLG
     FSELCRKLSV VARMGWNSSR FDCKVLLARA NRLNCINSVL DLGMNPPGKI STNSGRTFGP
     IGDYEPIYID TEGVVCLDVM EMFKSTYTKL PKFSLQYVSE VFLNEMAIIT RTPLDMVHHQ
     KQQRRVYNLM YSECLRQNIA FQDNMFNSKK VVTNDDVVGY SGAYVKDPVP GIHRRVGSLD
     VNSMYPTLII AYNLCYTTVI NYDDETPYKD EDFEVIEWED HIGCEHNPIV VEFESLKKIL
     YPKLQQNNTP SKRSPKGDGV VSNFFLPRNN KRCITNENDD VDEDEDQDIL NMVTRTKQPS
     IEEQRATIRY KLLKARISAM SGKRVCETQR LKVLKSSVRP GILPNVVNKL LVERKRIRNI
     ASVPGDPVEK ALLDKRQLAY KITANSIYGA TGASNGKLPC KNVAKAITAL GRKVIKESIQ
     MASDKGIPVI YGDTDSMYVQ LSDDLEDPWH YLQSLGDEIT SNLRKPMRIE SEDNISDVLF
     LGKKSYICRK LLKDGGISEK LDYHGGIAVR RDHSGFVKST HNKVVHAIFA DVSLQNVKHV
     IFEECLKLMR RKIPIDELTK TSEVKSIGDG FTLKPSMKNT TTLNSWKLGD YTVKKHPQHD
     TLSKEYLKRY YLEQLPAHVQ LEHKLMERGR SAVEGGRVEY LMVKRPGSKK SSASNIEEIT
     YFKENSSIIQ INELHYILQL VKPITKVCEA VWERSDIVVD AIKPICAYSK VLDEMNTKLY
     TPLVL