ID   DPOM_NEUCS              Reviewed;        1021 AA.
AC   P33537;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Probable DNA polymerase;
DE            EC=2.7.7.7;
OS   Neurospora crassa.
OG   Mitochondrion.
OG   Plasmid maranhar.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=5141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=AAREY-1E;
RX   PubMed=1423726; DOI=10.1007/bf00352440;
RA   Court D.A., Bertrand H.;
RT   "Genetic organization and structural features of maranhar, a senescence-
RT   inducing linear mitochondrial plasmid of Neurospora crassa.";
RL   Curr. Genet. 22:385-397(1992).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
CC   -!- MISCELLANEOUS: This DNA polymerase requires a protein as a primer.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family. {ECO:0000305}.
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DR   EMBL; X55361; CAA39046.1; -; Genomic_DNA.
DR   PIR; S26985; S26985.
DR   AlphaFoldDB; P33537; -.
DR   PRIDE; P33537; -.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 2.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR004868; DNA-dir_DNA_pol_B_mt/vir.
DR   InterPro; IPR015833; DNA-dir_DNA_pol_B_mt_lin_plsmd.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF03175; DNA_pol_B_2; 1.
DR   PIRSF; PIRSF006517; DPol_mt_plasmid; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; DNA-directed DNA polymerase; Mitochondrion;
KW   Nucleotidyltransferase; Plasmid; Transferase.
FT   CHAIN           1..1021
FT                   /note="Probable DNA polymerase"
FT                   /id="PRO_0000046554"
SQ   SEQUENCE   1021 AA;  119076 MW;  54B9A4C51CF5FE3A CRC64;
     MIKFYFTTFH MKFPARLFST SGNRANFEEN SSNEVQNQIK YLKDFKKENP KFNWESTTEP
     KHMILSNIGE YEKNDFNLKS LLNINEFNIN VELLRQLFMK LDKNFTYALG VILRNVDSNT
     NISVDRHFLV NFNTDPVIIL QQIYDRIIFL SEKYYLVPVD KLFIKLRKLN FKVKNPVFHP
     IAKEKTNIHT TIPKGKSKLS RAEFVPHTMD LKFYGVETKH DKEKNIRIFD NGKVILKVKI
     IKDGVYHLID VISRDNRLLY QFEDVKHGDG LKRYWINDNM YYYYYDNTLV NVETPQKVGN
     IEPAKRDKTQ DKKILAFDIE TFQVPTGNGD STMIAYACGF YDGKKSLTYY ISDFISQREM
     LLACIKDMLK YDKHTVYCHN FSKFDINFII KILVQEFVVE KIISKDLDIL SIKISYKFEP
     KKKGGKAERH TITIADSCRL LPGSLDKLAK DHNIITKKGK FPYKFVNKDN LEYVGLLPDY
     EYYIDPKKGE MITLFEWAAM YTNKWSMRKE TIIYLEKDIK ALYQLMMEMS NNTYSTFRIN
     ITRVKTASAL AFLVYRTIFL PNEVEEENET NSPNNILSLF DKKEEKKLTP KYFLPKLKGR
     LERAVRAAYF GGRNEIFIPI INNIFSFDFN SLYPTAMMMP MPVGIPVHTF CKNLNEIFGF
     VRAKIITPAI NIPVLPCRVK VNGVQKLIFP IGEWTGWYFS EELKLAVEYG YKIEVLESYV
     FEKRDDPFKE YIEHFASIKD NTKGSKKQMA KLLLNTLYGR TGMNDSAAEI KMLTTNELDN
     IQLTNNVIHE FEVDDDKHYV RYDKKPCPVL CAQSEKNYEL LSYLDGEKDD GFIINSTSIA
     AATASWSRIL MYKHIINSAY TDTDSIFVEK PLDSAFIGEG CGKFKAEYNG QLIKRAIFIS
     GKLYLLDFGG KLEIKCKGIT KNKDNTTHNL DINDFEALYN GESRVLFQER WGRSLELGTV
     TVKYQKYNLI SGYDKREKLY SLGKWVNTSP LCINENFEVI SKALVSDVGE SWYRKRIHYN
     K