DPP5_SCHPO
ID DPP5_SCHPO Reviewed; 683 AA.
AC Q9P778;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Dipeptidyl-peptidase 5;
DE EC=3.4.14.-;
DE AltName: Full=Dipeptidyl-peptidase V;
DE Short=DPP V;
DE Short=DppV;
DE Flags: Precursor;
GN ORFNames=SPBC1711.12;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1] {ECO:0000312|EMBL:CAB88242.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2] {ECO:0000305}
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Cytoplasm
CC {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the peptidase S9C family. {ECO:0000305}.
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DR EMBL; CU329671; CAB88242.1; -; Genomic_DNA.
DR RefSeq; NP_595885.1; NM_001021791.2.
DR AlphaFoldDB; Q9P778; -.
DR SMR; Q9P778; -.
DR BioGRID; 276217; 1.
DR DIP; DIP-59123N; -.
DR IntAct; Q9P778; 1.
DR STRING; 4896.SPBC1711.12.1; -.
DR ESTHER; schpo-SPBC1711.12; Prolyl_oligopeptidase_S9.
DR iPTMnet; Q9P778; -.
DR MaxQB; Q9P778; -.
DR PaxDb; Q9P778; -.
DR PRIDE; Q9P778; -.
DR EnsemblFungi; SPBC1711.12.1; SPBC1711.12.1:pep; SPBC1711.12.
DR GeneID; 2539662; -.
DR KEGG; spo:SPBC1711.12; -.
DR PomBase; SPBC1711.12; -.
DR VEuPathDB; FungiDB:SPBC1711.12; -.
DR eggNOG; KOG2100; Eukaryota.
DR HOGENOM; CLU_008615_0_1_1; -.
DR InParanoid; Q9P778; -.
DR OMA; MGRINGY; -.
DR PhylomeDB; Q9P778; -.
DR PRO; PR:Q9P778; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001375; Peptidase_S9.
DR Pfam; PF00326; Peptidase_S9; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Glycoprotein; Hydrolase; Nucleus; Protease; Reference proteome;
KW Secreted; Serine protease; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..683
FT /note="Dipeptidyl-peptidase 5"
FT /id="PRO_0000311722"
FT ACT_SITE 535
FT /note="Charge relay system"
FT /evidence="ECO:0000250|UniProtKB:P23687"
FT ACT_SITE 617
FT /note="Charge relay system"
FT /evidence="ECO:0000250|UniProtKB:P23687"
FT ACT_SITE 649
FT /note="Charge relay system"
FT /evidence="ECO:0000250|UniProtKB:P23687"
FT CARBOHYD 53
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 69
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 103
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 116
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 126
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 400
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 683 AA; 77766 MW; 6B66D518FD2D6604 CRC64;
MHSLFKQLVF FLVMTLTAAD KAAFDAESML EAPRRSAVVS NPLGNLGIFI ESNYSFADHK
YNSGIYLLNE STRNHQELLV HGKSNKALTW ITDSAFLYAR EDNSSSSSIL LFDVNNRSER
IIYNHNSSIS DIRIGEKNNH YRIVFSSVDN SLVKGPSNVH VYDHLFVRHW DRWNTGSRNT
LYFIELDKKT ENSNYFEISS EKAIDLLKET GLESPVEPFG GLSDFDSNYD KLVFVAKDPK
LNPATQTKTV VYEINLNTRN LKSLSTAKGA CSSPRLAKDG NHIAWLEMQT PQYESDQNQI
MVYESESGAK KHIARHWDRS PSSIEWGVFK GGEPGLFAIA ENYGKQILFF VSIFHHQVIP
MTEEHSVSSI SVPKSSSLWL TKSSLINPPY YAKINVETLN ESVLLENNVG LSPTSYEEIW
FPGTHGHRIH AWIVKPESFD KSKKYPVAVL IHGGPQGSWT DSWSTRWNPA VFANAGFIVF
ALDPTGSTGY GQRFTDSIAL DWGGKPYKDI ELGVEYIKNH LSYADSEKMV ALGASYGGYM
INWIQGHPLG RQFRALVCHD GVFNTLNTFY NTEELYFSIH DFGGTPWENR VIYERWNPSN
FVNYWATPEL VIHSSKDYRL TESEGIAAFN VLQYKGIPSR LLVFEDENHW VIKPDNSLRW
HKEVLSWILH YTKDCNANED ETF
