DPPA2_HUMAN
ID DPPA2_HUMAN Reviewed; 298 AA.
AC Q7Z7J5; Q8WVF0;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Developmental pluripotency-associated protein 2;
DE AltName: Full=Pluripotent embryonic stem cell-related gene 1 protein;
GN Name=DPPA2; Synonyms=PESCRG1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=15583978;
RA Du J., Lin G., Nie Z.Y., Lu G.X.;
RT "Molecular cloning and characterization analysis of HPESCRG1, a novel gene
RT expressed specifically in human embryonic stem cell.";
RL Zhonghua Yi Xue Yi Chuan Xue Za Zhi 21:542-547(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Binds to target gene promoters, including NKX2-5 and SYCE1,
CC but not GATA4, and may be involved in the maintenance of the active
CC epigenetic status of these genes. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with DPPA4. {ECO:0000250}.
CC -!- INTERACTION:
CC Q7Z7J5; P22607: FGFR3; NbExp=3; IntAct=EBI-741400, EBI-348399;
CC Q7Z7J5; Q14957: GRIN2C; NbExp=3; IntAct=EBI-741400, EBI-8285963;
CC Q7Z7J5; P06396: GSN; NbExp=3; IntAct=EBI-741400, EBI-351506;
CC Q7Z7J5; Q7KZS0: UBE2I; NbExp=3; IntAct=EBI-741400, EBI-10180829;
CC Q7Z7J5; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-741400, EBI-741480;
CC Q7Z7J5; Q9Y649; NbExp=3; IntAct=EBI-741400, EBI-25900580;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15583978}.
CC -!- TISSUE SPECIFICITY: Expressed in embryonic stem cells. No expression is
CC seen in 5 months embryo, mesenchymal stem cells, embryonic fibrocytes
CC and adult tissues. {ECO:0000269|PubMed:15583978}.
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DR EMBL; AY283672; AAP37285.1; -; mRNA.
DR EMBL; BC018070; AAH18070.1; -; mRNA.
DR CCDS; CCDS2956.1; -.
DR RefSeq; NP_620170.3; NM_138815.3.
DR RefSeq; XP_011510746.1; XM_011512444.2.
DR RefSeq; XP_011510747.1; XM_011512445.2.
DR AlphaFoldDB; Q7Z7J5; -.
DR SMR; Q7Z7J5; -.
DR BioGRID; 127407; 22.
DR IntAct; Q7Z7J5; 22.
DR STRING; 9606.ENSP00000417710; -.
DR iPTMnet; Q7Z7J5; -.
DR PhosphoSitePlus; Q7Z7J5; -.
DR SwissPalm; Q7Z7J5; -.
DR BioMuta; DPPA2; -.
DR DMDM; 116241341; -.
DR EPD; Q7Z7J5; -.
DR jPOST; Q7Z7J5; -.
DR MassIVE; Q7Z7J5; -.
DR MaxQB; Q7Z7J5; -.
DR PaxDb; Q7Z7J5; -.
DR PeptideAtlas; Q7Z7J5; -.
DR PRIDE; Q7Z7J5; -.
DR ProteomicsDB; 69552; -.
DR Antibodypedia; 32413; 309 antibodies from 31 providers.
DR DNASU; 151871; -.
DR Ensembl; ENST00000478945.1; ENSP00000417710.1; ENSG00000163530.4.
DR GeneID; 151871; -.
DR KEGG; hsa:151871; -.
DR MANE-Select; ENST00000478945.1; ENSP00000417710.1; NM_138815.4; NP_620170.3.
DR UCSC; uc003dxo.3; human.
DR CTD; 151871; -.
DR DisGeNET; 151871; -.
DR GeneCards; DPPA2; -.
DR HGNC; HGNC:19197; DPPA2.
DR HPA; ENSG00000163530; Tissue enriched (testis).
DR MIM; 614445; gene.
DR neXtProt; NX_Q7Z7J5; -.
DR OpenTargets; ENSG00000163530; -.
DR PharmGKB; PA134944028; -.
DR VEuPathDB; HostDB:ENSG00000163530; -.
DR eggNOG; ENOG502RVK6; Eukaryota.
DR GeneTree; ENSGT00390000004871; -.
DR HOGENOM; CLU_080062_1_0_1; -.
DR InParanoid; Q7Z7J5; -.
DR OMA; FCPKHSC; -.
DR OrthoDB; 1295613at2759; -.
DR PhylomeDB; Q7Z7J5; -.
DR TreeFam; TF338129; -.
DR PathwayCommons; Q7Z7J5; -.
DR SignaLink; Q7Z7J5; -.
DR BioGRID-ORCS; 151871; 49 hits in 1063 CRISPR screens.
DR ChiTaRS; DPPA2; human.
DR GeneWiki; Developmental_pluripotency_associated_2; -.
DR GenomeRNAi; 151871; -.
DR Pharos; Q7Z7J5; Tbio.
DR PRO; PR:Q7Z7J5; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q7Z7J5; protein.
DR Bgee; ENSG00000163530; Expressed in testis and 8 other tissues.
DR Genevisible; Q7Z7J5; HS.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0048731; P:system development; IBA:GO_Central.
DR InterPro; IPR039835; Dppa2.
DR InterPro; IPR039590; Dppa2/4.
DR InterPro; IPR025891; Dppa2/4_C_dom.
DR InterPro; IPR025892; Dppa2/4_central_dom.
DR InterPro; IPR003034; SAP_dom.
DR PANTHER; PTHR16073; PTHR16073; 1.
DR PANTHER; PTHR16073:SF10; PTHR16073:SF10; 1.
DR Pfam; PF14047; DCR; 1.
DR Pfam; PF14049; Dppa2_A; 1.
DR PROSITE; PS50800; SAP; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..298
FT /note="Developmental pluripotency-associated protein 2"
FT /id="PRO_0000239263"
FT DOMAIN 92..126
FT /note="SAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00186"
FT REGION 36..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 131
FT /note="R -> Q (in dbSNP:rs9809030)"
FT /id="VAR_028087"
FT CONFLICT 89
FT /note="L -> S (in Ref. 1; AAP37285)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 298 AA; 33784 MW; 87FBCCCF52E88B5D CRC64;
MSDANLDSSK KNFLEGEVDD EESVILTLVP VKDDANMEQM EPSVSSTSDV KLEKPKKYNP
GHLLQTNEQF TAPQKARCKI PALPLPTILP PINKVCRDTL RDWCQQLGLS TNGKKIEVYL
RLHRHAYPEQ RQDMPEMSQE TRLQRCSRKR KAVTKRARLQ RSYEMNERAE ETNTVEVITS
APGAMLASWA RIAARAVQPK ALNSCSIPVS VEAFLMQASG VRWCVVHGRL LSADTKGWVR
LQFHAGQAWV PTTHRRMISL FLLPACIFPS PGIEDNMLCP DCAKRNKKMM KRLMTVEK
