ID   DPPA3_BOVIN             Reviewed;         163 AA.
AC   A9Q1J7; A9Q1J8;
DT   31-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Developmental pluripotency-associated protein 3;
DE   AltName: Full=Stella-related protein;
GN   Name=DPPA3; Synonyms=STELLA, STELLAR;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=17988387; DOI=10.1186/1471-213x-7-125;
RA   Thelie A., Papillier P., Pennetier S., Perreau C., Traverso J.M.,
RA   Uzbekova S., Mermillod P., Joly C., Humblot P., Dalbies-Tran R.;
RT   "Differential regulation of abundance and deadenylation of maternal
RT   transcripts during bovine oocyte maturation in vitro and in vivo.";
RL   BMC Dev. Biol. 7:125-125(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA   Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA   Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
CC   -!- FUNCTION: Primordial germ cell (PGCs)-specific protein involved in
CC       epigenetic chromatin reprogramming in the zygote following
CC       fertilization. In zygotes, DNA demethylation occurs selectively in the
CC       paternal pronucleus before the first cell division, while the adjacent
CC       maternal pronucleus and certain paternally-imprinted loci are protected
CC       from this process. Participates in protection of DNA methylation in the
CC       maternal pronucleus by preventing conversion of 5mC to 5hmC:
CC       specifically recognizes and binds histone H3 dimethylated at 'Lys-9'
CC       (H3K9me2) on maternal genome, and protects maternal genome from TET3-
CC       mediated conversion to 5hmC and subsequent DNA demethylation. Does not
CC       bind paternal chromatin, which is mainly packed into protamine and does
CC       not contain much H3K9me2 mark. Also protects imprinted loci that are
CC       marked with H3K9me2 in mature sperm from DNA demethylation in early
CC       embryogenesis. May be important for the totipotent/pluripotent states
CC       continuing through preimplantation development. Also involved in
CC       chromatin condensation in oocytogenesis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Mainly localizes in the female pronucleus, localization to the
CC       male pronucleus in much weaker (By similarity). Expressed during
CC       blastocyst, morula and 4-cell embryo stages. {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Preferentially expressed in oocyte.
CC       {ECO:0000269|PubMed:17988387}.
CC   -!- DOMAIN: Mediates binding to H3K9me2 via N-terminal region, while
CC       ability to exclude TET3 from the maternal pronucleus requires the C-
CC       terminal part. {ECO:0000250}.
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DR   EMBL; EF446904; ABR15008.1; -; mRNA.
DR   EMBL; EF446905; ABR15009.1; -; mRNA.
DR   EMBL; DAAA02014397; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001104578.1; NM_001111108.2.
DR   RefSeq; NP_001104579.1; NM_001111109.2.
DR   AlphaFoldDB; A9Q1J7; -.
DR   STRING; 9913.ENSBTAP00000054822; -.
DR   PaxDb; A9Q1J7; -.
DR   PRIDE; A9Q1J7; -.
DR   Ensembl; ENSBTAT00000064942; ENSBTAP00000054536; ENSBTAG00000046609.
DR   Ensembl; ENSBTAT00000065996; ENSBTAP00000054822; ENSBTAG00000046609.
DR   GeneID; 616433; -.
DR   KEGG; bta:616433; -.
DR   CTD; 359787; -.
DR   VEuPathDB; HostDB:ENSBTAG00000046609; -.
DR   eggNOG; ENOG502TDBW; Eukaryota.
DR   GeneTree; ENSGT00800000124303; -.
DR   HOGENOM; CLU_107188_0_0_1; -.
DR   InParanoid; A9Q1J7; -.
DR   OMA; FRCSCHY; -.
DR   OrthoDB; 1539071at2759; -.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000046609; Expressed in oocyte and 18 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0035064; F:methylated histone binding; IBA:GO_Central.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:1901536; P:negative regulation of DNA demethylation; IBA:GO_Central.
DR   GO; GO:0044726; P:protection of DNA demethylation of female pronucleus; IBA:GO_Central.
DR   GO; GO:2000653; P:regulation of genetic imprinting; IBA:GO_Central.
DR   InterPro; IPR029096; Dppa3.
DR   PANTHER; PTHR31577; PTHR31577; 1.
DR   Pfam; PF15549; PGC7_Stella; 1.
PE   2: Evidence at transcript level;
KW   Chromatin regulator; Cytoplasm; Developmental protein; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..163
FT                   /note="Developmental pluripotency-associated protein 3"
FT                   /id="PRO_0000419973"
FT   CONFLICT        58
FT                   /note="P -> T (in Ref. 1; ABR15009)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   163 AA;  19078 MW;  C7EFCF8D91FC4D77 CRC64;
     MDSSEDNPTW TLESLKTSID DASQAMQVAT QLSEMLATNL SNLTLNPSIK LPYLPEYPSQ
     LTGQLPSEKT PHRRRGVRTV LSERRYRMQK LIESLRLRYA KGIPRSDSQR QLQQQEDTEI
     RSRVRRFQCT CSYCQFKRNP SDDNYENYYN TTYSNYAMES NES