ID   DPPA3_PSEAB             Reviewed;         533 AA.
AC   A0A0H2ZGN2;
DT   07-APR-2021, integrated into UniProtKB/Swiss-Prot.
DT   16-SEP-2015, sequence version 1.
DT   03-AUG-2022, entry version 24.
DE   RecName: Full=Di/tripeptide-binding protein 3 {ECO:0000305};
DE   Flags: Precursor;
GN   Name=dppA3 {ECO:0000303|PubMed:25338022};
GN   OrderedLocusNames=PA14_58390 {ECO:0000312|EMBL:ABJ13767.1};
OS   Pseudomonas aeruginosa (strain UCBPP-PA14).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCBPP-PA14;
RX   PubMed=17038190; DOI=10.1186/gb-2006-7-10-r90;
RA   Lee D.G., Urbach J.M., Wu G., Liberati N.T., Feinbaum R.L., Miyata S.,
RA   Diggins L.T., He J., Saucier M., Deziel E., Friedman L., Li L., Grills G.,
RA   Montgomery K., Kucherlapati R., Rahme L.G., Ausubel F.M.;
RT   "Genomic analysis reveals that Pseudomonas aeruginosa virulence is
RT   combinatorial.";
RL   Genome Biol. 7:R90.1-R90.14(2006).
RN   [2]
RP   FUNCTION, AND SUBUNIT.
RC   STRAIN=UCBPP-PA14;
RX   PubMed=25338022; DOI=10.1371/journal.pone.0111311;
RA   Pletzer D., Lafon C., Braun Y., Koehler T., Page M.G., Mourez M.,
RA   Weingart H.;
RT   "High-throughput screening of dipeptide utilization mediated by the ABC
RT   transporter DppBCDF and its substrate-binding proteins DppA1-A5 in
RT   Pseudomonas aeruginosa.";
RL   PLoS ONE 9:e111311-e111311(2014).
CC   -!- FUNCTION: Part of the ABC transporter DppABCDF involved in the uptake
CC       of various di/tripeptides (PubMed:25338022). Prefers dipeptides with
CC       acidic residues at the C-terminal end. Involved in the uptake of
CC       phaseolotoxin, a toxic tripeptide inhibiting the enzyme ornithine
CC       carbamoyltransferase (PubMed:25338022). {ECO:0000269|PubMed:25338022}.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (DppD and
CC       DppF), two transmembrane proteins (DppB and DppC) and a solute-binding
CC       protein (DppA3) (PubMed:25338022). Five orthologous SBPs (DppA1-A5) are
CC       present in P.aeruginosa, which increases the substrate specificity of
CC       the DppBCDF transporter (PubMed:25338022).
CC       {ECO:0000269|PubMed:25338022}.
CC   -!- SIMILARITY: Belongs to the bacterial solute-binding protein 5 family.
CC       {ECO:0000305}.
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DR   EMBL; CP000438; ABJ13767.1; -; Genomic_DNA.
DR   RefSeq; WP_003141334.1; NZ_CP034244.1.
DR   AlphaFoldDB; A0A0H2ZGN2; -.
DR   SMR; A0A0H2ZGN2; -.
DR   EnsemblBacteria; ABJ13767; ABJ13767; PA14_58390.
DR   KEGG; pau:PA14_58390; -.
DR   HOGENOM; CLU_017028_7_0_6; -.
DR   OMA; YDFFTWE; -.
DR   BioCyc; PAER208963:G1G74-4918-MON; -.
DR   Proteomes; UP000000653; Chromosome.
DR   GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR   GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:UniProt.
DR   GO; GO:0015833; P:peptide transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   InterPro; IPR030678; Peptide/Ni-bd.
DR   InterPro; IPR039424; SBP_5.
DR   InterPro; IPR023765; SBP_5_CS.
DR   InterPro; IPR000914; SBP_5_dom.
DR   PANTHER; PTHR30290; PTHR30290; 1.
DR   Pfam; PF00496; SBP_bac_5; 1.
DR   PIRSF; PIRSF002741; MppA; 1.
DR   PROSITE; PS01040; SBP_BACTERIAL_5; 1.
PE   1: Evidence at protein level;
KW   Peptide transport; Protein transport; Signal; Transport.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..533
FT                   /note="Di/tripeptide-binding protein 3"
FT                   /id="PRO_0000452190"
SQ   SEQUENCE   533 AA;  59791 MW;  DDAEC28C09BE3583 CRC64;
     MRKILPLRAW LAAGLILGSP FSHAASNLVF CSEGSPAGFD PAQYTTGTDY DATSVTLFNR
     LVQFERGGTR AIPALAESWD IGDDGKTYTF HLRKGVKFHS TDYFKPTREF NADDVLFTFE
     RMLDKNHPFR KAYPTEFPYF TDMGLDKNIA RVEKLDEHRV KFTLNEVDAA FIQNLAMDVA
     SIQSAEYAGQ LLEAGKPQQI NQKPIGTGPF ILSRYQKDAQ IRFKGNKDYW KPEDVKIDNL
     IFSINTDAAV RAQKLKAGEC QITLNPRPAD LKALQEAANL KVPSQPGFNL GYIAYNVTHK
     PFDQLEVRQA LDMAVNKQAI IDAVYQGAGQ LAVNGMPPTQ WSYDETIKDA PFDPAKAREL
     LKKAGVAEGT EITLWAMPVQ RPYNPNAKLM AEMIQADWAK IGIKARIVSY EWGEYIKRAH
     AGEHDAMLFG WTGDNGDPDN WLATLYGCDS INGNNVSKWC DAAYDKLVKA AKRVSDQDKR
     SELYKQAQHI LKEQVPITPI AHSTVYQPMN KSVHDFKISP FSRNAFYGVT NQP