ID   DPPA5_HUMAN             Reviewed;         116 AA.
AC   A6NC42; B2RPQ7;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Developmental pluripotency-associated 5 protein;
DE            Short=hDPPA5;
DE   AltName: Full=Embryonal stem cell-specific gene 1 protein;
DE            Short=ESG-1;
GN   Name=DPPA5; Synonyms=ESG1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   INDUCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=15790765; DOI=10.1634/stemcells.2004-0245;
RA   Kim S.-K., Suh M.R., Yoon H.S., Lee J.B., Oh S.K., Moon S.-Y., Moon S.H.,
RA   Lee J.Y., Hwang J.H., Cho W.J., Kim K.-S.;
RT   "Identification of developmental pluripotency associated 5 expression in
RT   human pluripotent stem cells.";
RL   Stem Cells 23:458-462(2005).
RN   [5]
RP   IDENTIFICATION.
RX   PubMed=17913455; DOI=10.1016/j.ygeno.2007.06.003;
RA   Pierre A., Gautier M., Callebaut I., Bontoux M., Jeanpierre E.,
RA   Pontarotti P., Monget P.;
RT   "Atypical structure and phylogenomic evolution of the new eutherian
RT   oocyte- and embryo-expressed KHDC1/DPPA5/ECAT1/OOEP gene family.";
RL   Genomics 90:583-594(2007).
CC   -!- FUNCTION: Involved in the maintenance of embryonic stem (ES) cell
CC       pluripotency. Dispensable for self-renewal of pluripotent ES cells and
CC       establishment of germ cells. Associates with specific target mRNAs (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in primordial germ (PGC), embryonic germ
CC       (EGC) and embryonic stem (ESC) cells. Not detected in embryonic
CC       carcinoma (ECC) cells. {ECO:0000269|PubMed:15790765}.
CC   -!- INDUCTION: Down-regulated in differentiated embryonic stem (ESC) cells,
CC       compared with strong expression in undifferentiated ESC cells.
CC       {ECO:0000269|PubMed:15790765}.
CC   -!- SIMILARITY: Belongs to the KHDC1 family. {ECO:0000305}.
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DR   EMBL; AC019205; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471051; EAW48774.1; -; Genomic_DNA.
DR   EMBL; BC137549; AAI37550.1; -; mRNA.
DR   EMBL; BC137558; AAI37559.1; -; mRNA.
DR   CCDS; CCDS34483.1; -.
DR   RefSeq; NP_001020461.1; NM_001025290.2.
DR   AlphaFoldDB; A6NC42; -.
DR   SMR; A6NC42; -.
DR   BioGRID; 131006; 6.
DR   STRING; 9606.ENSP00000359396; -.
DR   iPTMnet; A6NC42; -.
DR   PhosphoSitePlus; A6NC42; -.
DR   BioMuta; DPPA5; -.
DR   EPD; A6NC42; -.
DR   MassIVE; A6NC42; -.
DR   PaxDb; A6NC42; -.
DR   PeptideAtlas; A6NC42; -.
DR   PRIDE; A6NC42; -.
DR   Antibodypedia; 46318; 164 antibodies from 22 providers.
DR   DNASU; 340168; -.
DR   Ensembl; ENST00000370370.4; ENSP00000359396.3; ENSG00000203909.4.
DR   GeneID; 340168; -.
DR   KEGG; hsa:340168; -.
DR   MANE-Select; ENST00000370370.4; ENSP00000359396.3; NM_001025290.3; NP_001020461.1.
DR   UCSC; uc003pgs.3; human.
DR   CTD; 340168; -.
DR   GeneCards; DPPA5; -.
DR   HGNC; HGNC:19201; DPPA5.
DR   HPA; ENSG00000203909; Tissue enhanced (testis).
DR   MIM; 611111; gene.
DR   neXtProt; NX_A6NC42; -.
DR   OpenTargets; ENSG00000203909; -.
DR   PharmGKB; PA134964500; -.
DR   VEuPathDB; HostDB:ENSG00000203909; -.
DR   eggNOG; ENOG502RW7D; Eukaryota.
DR   GeneTree; ENSGT00940000154353; -.
DR   HOGENOM; CLU_169085_0_0_1; -.
DR   InParanoid; A6NC42; -.
DR   OMA; GGSRIPY; -.
DR   OrthoDB; 1502478at2759; -.
DR   PhylomeDB; A6NC42; -.
DR   TreeFam; TF338690; -.
DR   PathwayCommons; A6NC42; -.
DR   BioGRID-ORCS; 340168; 142 hits in 1057 CRISPR screens.
DR   GenomeRNAi; 340168; -.
DR   Pharos; A6NC42; Tbio.
DR   PRO; PR:A6NC42; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; A6NC42; protein.
DR   Bgee; ENSG00000203909; Expressed in secondary oocyte and 43 other tissues.
DR   Genevisible; A6NC42; HS.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR   CDD; cd12795; FILIA_N_like; 1.
DR   Gene3D; 3.30.1370.10; -; 1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR031952; MOEP19_KH-like.
DR   Pfam; PF16005; MOEP19; 1.
DR   SUPFAM; SSF54791; SSF54791; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Reference proteome; RNA-binding.
FT   CHAIN           1..116
FT                   /note="Developmental pluripotency-associated 5 protein"
FT                   /id="PRO_0000311975"
FT   DOMAIN          23..84
FT                   /note="KH; atypical"
SQ   SEQUENCE   116 AA;  13498 MW;  B143BAA8DC68D1BC CRC64;
     MGTLPARRHI PPWVKVPEDL KDPEVFQVQT RLLKAIFGPD GSRIPYIEQV SKAMLELKAL
     ESSDLTEVVV YGSYLYKLRT KWMLQSMAEW HRQRQERGML KLAEAMNALE LGPWMK