ID   DPPA5_PSEAB             Reviewed;         526 AA.
AC   A0A0H2ZI72;
DT   07-APR-2021, integrated into UniProtKB/Swiss-Prot.
DT   16-SEP-2015, sequence version 1.
DT   03-AUG-2022, entry version 23.
DE   RecName: Full=Probable di/tripeptide-binding protein 5 {ECO:0000305};
DE   Flags: Precursor;
GN   Name=dppA5 {ECO:0000303|PubMed:25338022};
GN   OrderedLocusNames=PA14_70200 {ECO:0000312|EMBL:ABJ14700.1};
OS   Pseudomonas aeruginosa (strain UCBPP-PA14).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCBPP-PA14;
RX   PubMed=17038190; DOI=10.1186/gb-2006-7-10-r90;
RA   Lee D.G., Urbach J.M., Wu G., Liberati N.T., Feinbaum R.L., Miyata S.,
RA   Diggins L.T., He J., Saucier M., Deziel E., Friedman L., Li L., Grills G.,
RA   Montgomery K., Kucherlapati R., Rahme L.G., Ausubel F.M.;
RT   "Genomic analysis reveals that Pseudomonas aeruginosa virulence is
RT   combinatorial.";
RL   Genome Biol. 7:R90.1-R90.14(2006).
RN   [2]
RP   FUNCTION, AND SUBUNIT.
RC   STRAIN=UCBPP-PA14;
RX   PubMed=25338022; DOI=10.1371/journal.pone.0111311;
RA   Pletzer D., Lafon C., Braun Y., Koehler T., Page M.G., Mourez M.,
RA   Weingart H.;
RT   "High-throughput screening of dipeptide utilization mediated by the ABC
RT   transporter DppBCDF and its substrate-binding proteins DppA1-A5 in
RT   Pseudomonas aeruginosa.";
RL   PLoS ONE 9:e111311-e111311(2014).
CC   -!- FUNCTION: Part of the ABC transporter DppABCDF involved in the uptake
CC       of various di/tripeptides. {ECO:0000305|PubMed:25338022}.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (DppD and
CC       DppF), two transmembrane proteins (DppB and DppC) and a solute-binding
CC       protein (DppA5) (Probable). Five orthologous SBPs (DppA1-A5) are
CC       present in P.aeruginosa, which increases the substrate specificity of
CC       the DppBCDF transporter (PubMed:25338022).
CC       {ECO:0000269|PubMed:25338022, ECO:0000305|PubMed:25338022}.
CC   -!- MISCELLANEOUS: DppA5 was not able to complement the DppA1-A5 penta
CC       mutant during high-throughput screening. {ECO:0000269|PubMed:25338022}.
CC   -!- SIMILARITY: Belongs to the bacterial solute-binding protein 5 family.
CC       {ECO:0000305}.
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DR   EMBL; CP000438; ABJ14700.1; -; Genomic_DNA.
DR   RefSeq; WP_003096557.1; NZ_CP034244.1.
DR   AlphaFoldDB; A0A0H2ZI72; -.
DR   SMR; A0A0H2ZI72; -.
DR   EnsemblBacteria; ABJ14700; ABJ14700; PA14_70200.
DR   KEGG; pau:PA14_70200; -.
DR   HOGENOM; CLU_017028_7_0_6; -.
DR   OMA; DPYYFNY; -.
DR   BioCyc; PAER208963:G1G74-5911-MON; -.
DR   Proteomes; UP000000653; Chromosome.
DR   GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR   GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:UniProt.
DR   GO; GO:0015833; P:peptide transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   InterPro; IPR030678; Peptide/Ni-bd.
DR   InterPro; IPR039424; SBP_5.
DR   InterPro; IPR000914; SBP_5_dom.
DR   PANTHER; PTHR30290; PTHR30290; 1.
DR   Pfam; PF00496; SBP_bac_5; 1.
DR   PIRSF; PIRSF002741; MppA; 1.
PE   1: Evidence at protein level;
KW   Peptide transport; Protein transport; Signal; Transport.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..526
FT                   /note="Probable di/tripeptide-binding protein 5"
FT                   /id="PRO_0000452192"
SQ   SEQUENCE   526 AA;  57893 MW;  E8A45F47516280C3 CRC64;
     MRLAAFSLFL APLLLAQPAA AATLSVCTEA SPEGFDVVQY NSLTTTNASA DVLMNRLVEF
     DAGKGTVVPS LAERWSVSDD GLSYRFDLRQ GVHFHSTAYF KPSRTLDADD VVFSFQRMLD
     PANPWHKVAQ NGFPHAQSMQ LPELIKRVEK SGDHQVLIVL DHPDATFLPM LSMGFASIYS
     AEYADQLMKA GTPEKLNTAP IGSGPFVFKR FQKDAVVRYA ANPEYFAGKP AVDALIFAIT
     PDANVRLQKL RRGECQIALS PKPLDVESAR KDASLKVEQT PAFMTAFVAL NTQHPPLDDP
     KVRQAINLAF DRTSYLQAVF EGSASAATGI YPPNTWSYAR DIPAYPHDPE QARKLLAGKQ
     LPELNIWTRP SGSLLNPNPS LGAQLLQADL AEAGIKANIR VIEWGELIRR AKNGEHDLLF
     MGWAGDNGDP DNFLTPQFSC ASVKSGLNFA RYCDPGLDKL IADGKAASSQ EQRTGLYHQA
     QKLIHEQALW LPLAHPTAFA LTRQEVQGYQ VNPFGRQDFS RVAVKR