DPPC_BACSU
ID DPPC_BACSU Reviewed; 320 AA.
AC P26904; O34373; Q45678;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 15-JUL-1999, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Dipeptide transport system permease protein DppC;
GN Name=dppC; Synonyms=dciAC; OrderedLocusNames=BSU12940;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC STRAIN=168;
RX PubMed=1766370; DOI=10.1111/j.1365-2958.1991.tb00814.x;
RA Mathiopoulos C., Mueller J.P., Slack F.J., Murphy C.G., Patankar S.,
RA Bukusoglu G., Sonenshein A.L.;
RT "A Bacillus subtilis dipeptide transport system expressed early during
RT sporulation.";
RL Mol. Microbiol. 5:1903-1913(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RA Devine K.M.;
RT "Sequence of the Bacillus subtilis genome between xlyA and ykoR.";
RL Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 46-85.
RX PubMed=3145906; DOI=10.1016/0378-1119(88)90207-7;
RA Smith H., de Jong A., Bron S., Venema G.;
RT "Characterization of signal-sequence-coding regions selected from the
RT Bacillus subtilis chromosome.";
RL Gene 70:351-361(1988).
CC -!- FUNCTION: Probably part of the ABC transporter DppBCDE involved in
CC dipeptide transport (Probable). Responsible for the translocation of
CC the substrate across the membrane (Probable). {ECO:0000305,
CC ECO:0000305|PubMed:1766370}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- DEVELOPMENTAL STAGE: Expressed early during sporulation.
CC -!- INDUCTION: Nutrient deficiency conditions, which also induce
CC sporulation.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. OppBC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA22823.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
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DR EMBL; X56678; CAA40004.1; -; Genomic_DNA.
DR EMBL; AJ002571; CAA05574.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB13151.1; -; Genomic_DNA.
DR EMBL; M22907; AAA22823.1; ALT_SEQ; Genomic_DNA.
DR PIR; S16649; S16649.
DR RefSeq; NP_389177.1; NC_000964.3.
DR RefSeq; WP_003245702.1; NZ_JNCM01000035.1.
DR AlphaFoldDB; P26904; -.
DR STRING; 224308.BSU12940; -.
DR TCDB; 3.A.1.5.2; the atp-binding cassette (abc) superfamily.
DR PaxDb; P26904; -.
DR PRIDE; P26904; -.
DR EnsemblBacteria; CAB13151; CAB13151; BSU_12940.
DR GeneID; 938038; -.
DR KEGG; bsu:BSU12940; -.
DR PATRIC; fig|224308.179.peg.1406; -.
DR eggNOG; COG1173; Bacteria.
DR InParanoid; P26904; -.
DR OMA; TDWFLVM; -.
DR PhylomeDB; P26904; -.
DR BioCyc; BSUB:BSU12940-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015833; P:peptide transport; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd06261; TM_PBP2; 1.
DR Gene3D; 1.10.3720.10; -; 1.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR InterPro; IPR025966; OppC_N.
DR Pfam; PF00528; BPD_transp_1; 1.
DR Pfam; PF12911; OppC_N; 1.
DR SUPFAM; SSF161098; SSF161098; 1.
DR PROSITE; PS50928; ABC_TM1; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Peptide transport; Protein transport;
KW Reference proteome; Sporulation; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..320
FT /note="Dipeptide transport system permease protein DppC"
FT /id="PRO_0000060004"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 154..176
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 230..252
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 267..287
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 289..309
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 117..307
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT CONFLICT 232
FT /note="P -> R (in Ref. 1; CAA40004)"
FT /evidence="ECO:0000305"
FT CONFLICT 298
FT /note="L -> S (in Ref. 1; CAA40004)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 320 AA; 35803 MW; F376C504CC1DA729 CRC64;
MNLPVQTDER QPEQHNQVPD EWFVLNQEKN READSVKRPS LSYTQDAWRR LKKNKLAMAG
LFILLFLFVM AVIGPFLSPH SVVRQSLTEQ NLPPSADHWF GTDELGRDVF TRTWYGARIS
LFVGVMAALI DFLIGVIYGG VAGYKGGRID SIMMRIIEVL YGLPYLLVVI LLMVLMGPGL
GTIIVALTVT GWVGMARIVR GQVLQIKNYE YVLASKTFGA KTFRIIRKNL LPNTMGAIIV
QMTLTVPAAI FAESFLSFLG LGIQAPFASW GVMANDGLPT ILSGHWWRLF FPAFFISLTM
YAFNVLGDGL QDALDPKLRR
