ID   DPPC_HAEIN              Reviewed;         295 AA.
AC   P51000;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Dipeptide transport system permease protein DppC {ECO:0000250|UniProtKB:P0AEG1};
GN   Name=dppC; OrderedLocusNames=HI_1186;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=8550458; DOI=10.1128/jb.178.2.396-402.1996;
RA   Preston A., Maskell D., Johnson A., Moxon E.R.;
RT   "Altered lipopolysaccharide characteristic of the I69 phenotype in
RT   Haemophilus influenzae results from mutations in a novel gene, isn.";
RL   J. Bacteriol. 178:396-402(1996).
CC   -!- FUNCTION: Part of the ABC transporter DppBCDF involved in dipeptide
CC       transport. Responsible for the translocation of the substrate across
CC       the membrane. {ECO:0000250|UniProtKB:P0AEG1}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. OppBC subfamily. {ECO:0000305}.
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DR   EMBL; L42023; AAC22839.1; -; Genomic_DNA.
DR   EMBL; U17295; AAA95973.1; -; Genomic_DNA.
DR   RefSeq; NP_439342.1; NC_000907.1.
DR   RefSeq; WP_005653671.1; NC_000907.1.
DR   AlphaFoldDB; P51000; -.
DR   STRING; 71421.HI_1186; -.
DR   TCDB; 3.A.1.5.27; the atp-binding cassette (abc) superfamily.
DR   EnsemblBacteria; AAC22839; AAC22839; HI_1186.
DR   KEGG; hin:HI_1186; -.
DR   PATRIC; fig|71421.8.peg.1237; -.
DR   eggNOG; COG1173; Bacteria.
DR   HOGENOM; CLU_028518_1_1_6; -.
DR   OMA; RAWWVVS; -.
DR   PhylomeDB; P51000; -.
DR   BioCyc; HINF71421:G1GJ1-1217-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0071916; F:dipeptide transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd06261; TM_PBP2; 1.
DR   Gene3D; 1.10.3720.10; -; 1.
DR   InterPro; IPR000515; MetI-like.
DR   InterPro; IPR035906; MetI-like_sf.
DR   InterPro; IPR025966; OppC_N.
DR   Pfam; PF00528; BPD_transp_1; 1.
DR   Pfam; PF12911; OppC_N; 1.
DR   SUPFAM; SSF161098; SSF161098; 1.
DR   PROSITE; PS50928; ABC_TM1; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Peptide transport;
KW   Protein transport; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..295
FT                   /note="Dipeptide transport system permease protein DppC"
FT                   /id="PRO_0000060012"
FT   TRANSMEM        27..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        132..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        156..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        262..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   DOMAIN          93..282
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ   SEQUENCE   295 AA;  31840 MW;  F0CBB8C8A7E4F2C0 CRC64;
     MSDTPLTFAP KTPLQEFWFY FKQNRGALIG LIFILIVALI SILAPYIAPF DPTEQNRTAL
     LLPPAWYEGG NPAYLLGTDD IGRDILSRII YGTRISVFAG FIIVLLSCAF GTSLGLISGY
     YGGVLDTIII RLIDIMLAIP NLLLTIVVVS ILEPSLANAT LAIAVVSIPS YVRLTRAAMM
     NEKNRDYVTS SKVAGAGILR LMFIVILPNC LAPLIVQMTM GISNAILELA TLGFLGIGAK
     PPTPELGTML SEARGFMQAA NWLVTIPGLV ILSLVLAFNL MGDGLRDALD PKLKQ