ID   DPPC_LACLM              Reviewed;         343 AA.
AC   A2RI76;
DT   07-APR-2021, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Dipeptide transport system permease protein DppC {ECO:0000305};
GN   Name=dppC {ECO:0000303|PubMed:11409543};
GN   OrderedLocusNames=llmg_0365 {ECO:0000312|EMBL:CAL96970.1};
OS   Lactococcus lactis subsp. cremoris (strain MG1363).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus; Lactococcus cremoris subsp. cremoris.
OX   NCBI_TaxID=416870;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND SUBUNIT.
RC   STRAIN=MG1363;
RX   PubMed=11409543; DOI=10.1007/s002030100270;
RA   Sanz Y., Lanfermeijer F.C., Renault P., Bolotin A., Konings W.N.,
RA   Poolman B.;
RT   "Genetic and functional characterization of dpp genes encoding a dipeptide
RT   transport system in Lactococcus lactis.";
RL   Arch. Microbiol. 175:334-343(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MG1363;
RX   PubMed=17307855; DOI=10.1128/jb.01768-06;
RA   Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C.,
RA   Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P.,
RA   van Sinderen D., Kok J.;
RT   "The complete genome sequence of the lactic acid bacterial paradigm
RT   Lactococcus lactis subsp. cremoris MG1363.";
RL   J. Bacteriol. 189:3256-3270(2007).
CC   -!- FUNCTION: Part of the ABC transporter DppABCDF involved in dipeptide
CC       transport (PubMed:11409543). Responsible for the translocation of the
CC       substrate across the membrane (Probable). {ECO:0000269|PubMed:11409543,
CC       ECO:0000305}.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (DppD and
CC       DppF), two transmembrane proteins (DppB and DppC) and a solute-binding
CC       protein (DppA). {ECO:0000305|PubMed:11409543}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. OppBC subfamily. {ECO:0000305}.
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DR   EMBL; AM406671; CAL96970.1; -; Genomic_DNA.
DR   RefSeq; WP_011834422.1; NZ_WJVF01000001.1.
DR   AlphaFoldDB; A2RI76; -.
DR   STRING; 416870.llmg_0365; -.
DR   EnsemblBacteria; CAL96970; CAL96970; llmg_0365.
DR   GeneID; 61108669; -.
DR   KEGG; llm:llmg_0365; -.
DR   eggNOG; COG1173; Bacteria.
DR   HOGENOM; CLU_028518_1_0_9; -.
DR   OMA; YYRVVRN; -.
DR   PhylomeDB; A2RI76; -.
DR   BioCyc; LLAC416870:LLMG_RS01880-MON; -.
DR   Proteomes; UP000000364; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015833; P:peptide transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   CDD; cd06261; TM_PBP2; 1.
DR   Gene3D; 1.10.3720.10; -; 1.
DR   InterPro; IPR000515; MetI-like.
DR   InterPro; IPR035906; MetI-like_sf.
DR   InterPro; IPR025966; OppC_N.
DR   Pfam; PF00528; BPD_transp_1; 1.
DR   Pfam; PF12911; OppC_N; 1.
DR   SUPFAM; SSF161098; SSF161098; 1.
DR   PROSITE; PS50928; ABC_TM1; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Peptide transport; Protein transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..343
FT                   /note="Dipeptide transport system permease protein DppC"
FT                   /id="PRO_0000452195"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        259..279
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        309..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          140..329
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ   SEQUENCE   343 AA;  37518 MW;  6AB8F6B684206238 CRC64;
     MENLNKDFTL VGSKGSDSTE KIAKPALSFF QDAWRRFKKN KIALVAMWII AITLVFSVIS
     AFVVPQSKAN YFNPNKSQVY GNLPPKLSGD LPFWNGDFKA PGSAEKTDVY KAQGVPEKDK
     YVFGTDKYGR SLAKRTVVGL RISLIIALAA ALIDLVIGVT YGIISGWMGG KVDMVMQRII
     EIIQSVPNLV VVTMLALLLG QGISSIIIAI GLFAWTGMAR QVRNMVLSYK ERDFVLASKT
     LGQSTWKIAV KHLLPNVSGV IVVQIMFDIP SMIMYEAVLS AINLGVKPPT SSLGTLINDG
     IASLQFYPFQ LIIPAIVLSV LSLTFIFFGD GLRDAFDPRA SED