ADEC_THEM4
ID ADEC_THEM4 Reviewed; 574 AA.
AC A6LNR9;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Adenine deaminase {ECO:0000255|HAMAP-Rule:MF_01518};
DE Short=Adenase {ECO:0000255|HAMAP-Rule:MF_01518};
DE Short=Adenine aminase {ECO:0000255|HAMAP-Rule:MF_01518};
DE EC=3.5.4.2 {ECO:0000255|HAMAP-Rule:MF_01518};
GN Name=ade {ECO:0000255|HAMAP-Rule:MF_01518}; OrderedLocusNames=Tmel_1731;
OS Thermosipho melanesiensis (strain DSM 12029 / CIP 104789 / BI429).
OC Bacteria; Thermotogae; Thermotogales; Fervidobacteriaceae; Thermosipho.
OX NCBI_TaxID=391009;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12029 / CIP 104789 / BI429;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Detter J.C.,
RA Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Mikhailova N., Nelson K., Gogarten J.P., Noll K., Richardson P.;
RT "Complete sequence of Thermosipho melanesiensis BI429.";
RL Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC Adenine deaminase family. {ECO:0000255|HAMAP-Rule:MF_01518}.
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DR EMBL; CP000716; ABR31570.1; -; Genomic_DNA.
DR RefSeq; WP_012057929.1; NC_009616.1.
DR AlphaFoldDB; A6LNR9; -.
DR SMR; A6LNR9; -.
DR STRING; 391009.Tmel_1731; -.
DR PRIDE; A6LNR9; -.
DR EnsemblBacteria; ABR31570; ABR31570; Tmel_1731.
DR KEGG; tme:Tmel_1731; -.
DR eggNOG; COG1001; Bacteria.
DR HOGENOM; CLU_027935_0_0_0; -.
DR OMA; TDHECFT; -.
DR Proteomes; UP000001110; Chromosome.
DR GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR CDD; cd01295; AdeC; 1.
DR Gene3D; 2.30.40.10; -; 1.
DR HAMAP; MF_01518; Adenine_deamin; 1.
DR InterPro; IPR006679; Adenine_deam.
DR InterPro; IPR026912; Adenine_deam_C.
DR InterPro; IPR006680; Amidohydro-rel.
DR InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR InterPro; IPR032466; Metal_Hydrolase.
DR PANTHER; PTHR11113:SF2; PTHR11113:SF2; 1.
DR Pfam; PF13382; Adenine_deam_C; 1.
DR Pfam; PF01979; Amidohydro_1; 1.
DR SUPFAM; SSF51338; SSF51338; 1.
DR SUPFAM; SSF51556; SSF51556; 1.
DR TIGRFAMs; TIGR01178; ade; 1.
PE 3: Inferred from homology;
KW Hydrolase; Manganese.
FT CHAIN 1..574
FT /note="Adenine deaminase"
FT /id="PRO_1000068614"
SQ SEQUENCE 574 AA; 63652 MW; B91D6D18BF4A0AFF CRC64;
MKIKEIIPVA LGEKTPDLLI KNVKLLNVYT GNIEKTNIAI LKKRIAGIGN EYNVGKEIFN
AKNLYAIPGL IDAHVHIESS MLSPIEFAKM ILPNGTTTII ADPHEIANVL GVEGINYMIK
ATEGIPLNVY FAIPSAVPAT FLETSGAILG AEDMVSLLEK YPFRLIALGE VMNYPGVLNC
DRELITKIEI LRHKYKKIDG HAPGLSGKQL NAYIDAFVRS DHECETKSEA LEKLSKGMHI
FIREGTAARN LRSLIPAVNI LNHFFFSFCT DDRDPEDIYK RGHINQIVKE AIGQGLDPVI
AIRMATINTA KYFNLRSMGA ISPGYKSDIV LVDNLYDFNI LYVIKDSKFV VKDGKIDLKI
ESVFKDVPTT IGKINITKNY SLKVKNRNKK IRIISIKKFS LITEESIVSP KVSKNEIISD
VENDIVKIAV FDRHNASGFS IGFVKGTGIK NGAIATTIGH DSHNLAVLGT NDKDMELAIK
RILEINGGIV VIKDKKVISE LSLPIAGLMS DETYNTVIKK LQHLKKSIEK LGTKNDVLMN
IHFLQLAVIP KLKITDKGLI DVENQKIVDL FVEV
