ID   DPP_GIAIN               Reviewed;         761 AA.
AC   Q95WU5; A8BCK9;
DT   09-JAN-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Dipeptidyl-peptidase 4;
DE            EC=3.4.14.-;
DE   AltName: Full=Dipeptidyl-aminopeptidase;
DE   AltName: Full=Dipeptidylpeptidase IV;
DE            Short=DPP IV;
DE   Flags: Precursor;
GN   Name=DPP;
OS   Giardia intestinalis (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=5741;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 256-266, SUBCELLULAR
RP   LOCATION, INDUCTION, AND DEVELOPMENTAL STAGE.
RC   STRAIN=WB1267;
RX   PubMed=12049634; DOI=10.1042/bj20020025;
RA   Touz M.C., Nores M.J., Slavin I., Piacenza L., Acosta D., Carmona C.,
RA   Lujan H.D.;
RT   "Membrane-associated dipeptidyl peptidase IV is involved in encystation-
RT   specific gene expression during Giardia differentiation.";
RL   Biochem. J. 364:703-710(2002).
CC   -!- FUNCTION: May be involved in metabolism of dipeptides or may affect
CC       host defense mechanisms. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:12049634}.
CC       Note=Associated with trophozoite membrane.
CC   -!- DEVELOPMENTAL STAGE: Expressed throughout the life cycle, but
CC       expression is slightly decreased during encystation.
CC       {ECO:0000269|PubMed:12049634}.
CC   -!- INDUCTION: Expression increased in response to the protease inhibitor
CC       bestatin. {ECO:0000269|PubMed:12049634}.
CC   -!- SIMILARITY: Belongs to the peptidase S9C family. {ECO:0000305}.
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DR   EMBL; AF293412; AAK97082.1; -; Genomic_DNA.
DR   RefSeq; XP_001707929.1; XM_001707877.1.
DR   AlphaFoldDB; Q95WU5; -.
DR   ESTHER; giain-Q95WU5; Prolyl_oligopeptidase_S9.
DR   MEROPS; S09.056; -.
DR   GeneID; 5700838; -.
DR   KEGG; gla:GL50803_006148; -.
DR   VEuPathDB; GiardiaDB:DHA2_6148; -.
DR   VEuPathDB; GiardiaDB:GL50581_2060; -.
DR   VEuPathDB; GiardiaDB:GL50803_006148; -.
DR   eggNOG; KOG2100; Eukaryota.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR001375; Peptidase_S9.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   1: Evidence at protein level;
KW   Aminopeptidase; Direct protein sequencing; Hydrolase; Membrane; Protease;
KW   Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..761
FT                   /note="Dipeptidyl-peptidase 4"
FT                   /id="PRO_0000420611"
FT   ACT_SITE        622
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        706
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        738
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   761 AA;  87648 MW;  620D4D34A2A114EA CRC64;
     MTLSAWIILV TLAMASVLTP EDNVRLRRLT AYVANADASI VLLTYTEYEE GTNHGNSMLW
     RINDPLEAEY PFDPDDISLL NAERVCPELV GVGDLQYSTH NQAFYFTAQG PDGTSQVYSY
     NHKLETCTQI SFLPISVSNL KVSPKGNSVL FSAEIFVYPN NHASVDDPLN FAHDEFARIQ
     ARPYKAFAYE QLYTRHWDED ILPSQYRHLF AARLERSSEY DDDYVRITVD NSIDLMPRFD
     GDCPMRPFAD ASSYTFDSHG RYVAFVTQVG STAAFYTNDS IWITDLQQFL DAKKPVRDVV
     LPLRCATCWN KARDQRPAFS YDGIFLYYAS MDEEQSESDL LRLRKQNVSD LFEYDCDSLF
     CGPVTGEGVF NLTAGVFDRS IGQFIIPTDS TEDSIYILAE DHARTNLFRY NEESSTVTRL
     TYNGTLGSLL YLRHNKIFLA TMSSYTRPTD LVMLDLTVAT EFTATRDPSD TMKDDLIKIS
     YLTDLNRQRL RHIDELQEPE EFYLPSKSFP DQYVHSWYFA PANLRDSHEY PLILYVHGGP
     ESPWANSWSY RWNPQLIAAR GYGVLATNFH GSSSFGEVFQ KSVRGNWYSY PLEDIMDAWS
     NIYTHADKAY LSREKVCAMG ASFGATFMNY MNSHVNNVTC YVTHDGVFDT MCNALETDEL
     FFPVRELGGF LLDEQVDNQQ LYEKWNPARF VENMSAPMLV IHGQKDYRIQ VYHGISLFQA
     LRLRGIKTKL VYFPTQSHWV WQPQESLFWH TQVFDWLDTY L