ID   DPRA_MYCTU              Reviewed;         389 AA.
AC   P9WL29; L0TDP5; Q10817;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 34.
DE   RecName: Full=Putative DNA processing protein DprA;
GN   Name=dprA {ECO:0000305}; OrderedLocusNames=Rv2896c; ORFNames=MTCY274.27c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND INDUCTION.
RX   PubMed=22375954; DOI=10.1186/1477-5956-10-14;
RA   Singhal N., Sharma P., Kumar M., Joshi B., Bisht D.;
RT   "Analysis of intracellular expressed proteins of Mycobacterium tuberculosis
RT   clinical isolates.";
RL   Proteome Sci. 10:14-14(2012).
CC   -!- FUNCTION: May help load RecA onto ssDNA (By similarity).
CC       {ECO:0000250|UniProtKB:Q8DPI7}.
CC   -!- INDUCTION: Induced when cells are grown in human macrophages (THP-1
CC       macrophage cell line) (PubMed:22375954). {ECO:0000269|PubMed:22375954}.
CC   -!- SIMILARITY: Belongs to the DprA/Smf family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP45698.1; -; Genomic_DNA.
DR   PIR; C70926; C70926.
DR   RefSeq; NP_217412.2; NC_000962.3.
DR   RefSeq; WP_003414694.1; NZ_NVQJ01000006.1.
DR   AlphaFoldDB; P9WL29; -.
DR   SMR; P9WL29; -.
DR   STRING; 83332.Rv2896c; -.
DR   PaxDb; P9WL29; -.
DR   GeneID; 887177; -.
DR   KEGG; mtu:Rv2896c; -.
DR   TubercuList; Rv2896c; -.
DR   eggNOG; COG0758; Bacteria.
DR   eggNOG; COG1378; Bacteria.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0009294; P:DNA-mediated transformation; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR003488; DprA.
DR   InterPro; IPR041614; DprA_WH.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR43022; PTHR43022; 1.
DR   Pfam; PF02481; DNA_processg_A; 1.
DR   Pfam; PF17782; DprA_WH; 1.
DR   TIGRFAMs; TIGR00732; dprA; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..389
FT                   /note="Putative DNA processing protein DprA"
FT                   /id="PRO_0000104095"
SQ   SEQUENCE   389 AA;  40100 MW;  37FC5B98CC911F8A CRC64;
     MIDPTARAWA YLSRVAEPPC AQLAALVRCV GPVEAADRVR RGQVGNELAQ HTGARREIDR
     AADDLELLMR RGGRLITPDD DEWPVLAFAA FSGAGARARP CGHSPLVLWA LGPARLDEVA
     PRAAAVVGTR AATAYGEHVA ADLAAGLAER DVAVVSGGAY GIDGAAHRAA LDSEGITVAV
     LAGGFDIPYP AGHSALLHRI AQHGVLFTEY PPGVRPARHR FLTRNRLVAA VARAAVVVEA
     GLRSGAANTA AWARALGRVV AAVPGPVTSS ASAGCHTLLR HGAELVTRAD DIVEFVGHIG
     ELAGDEPRPG AALDVLSEAE RQVYEALPGR GAATIDEIAV GSGLLPAQVL GPLAILEVAG
     LAECRDGRWR ILRAGAGQAA AKGAAARLV