DPRX_HUMAN
ID DPRX_HUMAN Reviewed; 191 AA.
AC A6NFQ7;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Divergent paired-related homeobox {ECO:0000305};
GN Name=DPRX {ECO:0000312|HGNC:HGNC:32166};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP IDENTIFICATION.
RX PubMed=17005330; DOI=10.1016/j.gene.2006.07.034;
RA Booth H.A., Holland P.W.H.;
RT "Annotation, nomenclature and evolution of four novel homeobox genes
RT expressed in the human germ line.";
RL Gene 387:7-14(2007).
RN [3]
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=27412763; DOI=10.1038/srep28995;
RA Madissoon E., Jouhilahti E.M., Vesterlund L., Toehoenen V., Krjutskov K.,
RA Petropoulos S., Einarsdottir E., Linnarsson S., Lanner F., Maansson R.,
RA Hovatta O., Buerglin T.R., Katayama S., Kere J.;
RT "Characterization and target genes of nine human PRD-like homeobox domain
RT genes expressed exclusively in early embryos.";
RL Sci. Rep. 6:28995-28995(2016).
CC -!- FUNCTION: Transcription factor that acts as repressor.
CC {ECO:0000269|PubMed:27412763}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- DEVELOPMENTAL STAGE: Expressed in single blastomeres from 8-cell stage
CC embryos. {ECO:0000269|PubMed:27412763}.
CC -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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DR EMBL; AC011487; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS33103.1; -.
DR RefSeq; NP_001012746.1; NM_001012728.1.
DR RefSeq; XP_011525313.1; XM_011527011.2.
DR RefSeq; XP_011525314.1; XM_011527012.2.
DR AlphaFoldDB; A6NFQ7; -.
DR SMR; A6NFQ7; -.
DR STRING; 9606.ENSP00000365838; -.
DR iPTMnet; A6NFQ7; -.
DR PhosphoSitePlus; A6NFQ7; -.
DR BioMuta; DPRX; -.
DR EPD; A6NFQ7; -.
DR PaxDb; A6NFQ7; -.
DR PeptideAtlas; A6NFQ7; -.
DR PRIDE; A6NFQ7; -.
DR Antibodypedia; 49837; 37 antibodies from 12 providers.
DR DNASU; 503834; -.
DR Ensembl; ENST00000376650.1; ENSP00000365838.1; ENSG00000204595.1.
DR GeneID; 503834; -.
DR KEGG; hsa:503834; -.
DR MANE-Select; ENST00000376650.2; ENSP00000365838.1; NM_001012728.2; NP_001012746.1.
DR UCSC; uc002qcf.1; human.
DR CTD; 503834; -.
DR DisGeNET; 503834; -.
DR GeneCards; DPRX; -.
DR HGNC; HGNC:32166; DPRX.
DR HPA; ENSG00000204595; Tissue enhanced (placenta, skeletal muscle).
DR MIM; 611165; gene.
DR neXtProt; NX_A6NFQ7; -.
DR PharmGKB; PA142671957; -.
DR VEuPathDB; HostDB:ENSG00000204595; -.
DR eggNOG; KOG0490; Eukaryota.
DR GeneTree; ENSGT00640000091698; -.
DR HOGENOM; CLU_135951_0_0_1; -.
DR InParanoid; A6NFQ7; -.
DR OMA; HPIGLVY; -.
DR OrthoDB; 1203014at2759; -.
DR PhylomeDB; A6NFQ7; -.
DR SignaLink; A6NFQ7; -.
DR BioGRID-ORCS; 503834; 8 hits in 1082 CRISPR screens.
DR ChiTaRS; DPRX; human.
DR GenomeRNAi; 503834; -.
DR Pharos; A6NFQ7; Tdark.
DR PRO; PR:A6NFQ7; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; A6NFQ7; protein.
DR Bgee; ENSG00000204595; Expressed in placenta and 35 other tissues.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..191
FT /note="Divergent paired-related homeobox"
FT /id="PRO_0000311326"
FT DNA_BIND 16..75
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 191 AA; 21648 MW; D804219AD5A69066 CRC64;
MPGSEDLRKG KDQMHSHRKR TMFTKKQLED LNILFNENPY PNPSLQKEMA SKIDIHPTVL
QVWFKNHRAK LKKAKCKHIH QKQETPQPPI PEGGVSTSVG LRNADTLPRL PNAAHPIGLV
YTGHRVPSFQ LILYPNLKVP ANDFIGHRIV HFGCCRDPNI YCLYPILESQ VCAPSFHSGS
PACSSNQSRE R
