ID   DPSG_STRPE              Reviewed;          84 AA.
AC   Q9ZAU0;
DT   19-MAR-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Anthracycline acyl carrier protein DpsG;
GN   Name=dpsG;
OS   Streptomyces peucetius.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1950;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=ATCC 29050 / DSM 40754 / JCM 9920 / NBRC 100596 / NCIMB 10972;
RX   PubMed=9864344; DOI=10.1128/jb.181.1.305-318.1999;
RA   Lomovskaya N., Otten S.L., Doi-Katayama Y., Fonstein L., Liu X.-C.,
RA   Takatsu T., Inventi A., Filippi S., Torti F., Colombo A.L.,
RA   Hutchinson C.R.;
RT   "Doxorubicin overproduction in Streptomyces peucetius: cloning and
RT   characterization of the dnrU ketoreductase and dnrV genes and the doxA
RT   cytochrome P-450 hydroxylase gene.";
RL   J. Bacteriol. 181:305-318(1999).
CC   -!- FUNCTION: Involved in the biosynthesis of aklanonate which is an
CC       important precursor common to the formation of the clinically
CC       significant anthracyclines such as carminomycin, daunorubicin
CC       (daunomycin), rhodomycin, aclacinomycin T (aklavin) and aclacinomycin A
CC       (aclarubicin). These compounds are aromatic polyketide antibiotics that
CC       exhibit high cytotoxicity and are widely applied in the chemotherapy of
CC       a variety of cancers. {ECO:0000269|PubMed:9864344}.
CC   -!- PATHWAY: Antibiotic biosynthesis; daunorubicin biosynthesis.
CC   -!- PATHWAY: Antibiotic biosynthesis; carminomycin biosynthesis.
CC   -!- PATHWAY: Antibiotic biosynthesis; rhodomycin biosynthesis.
CC   -!- PATHWAY: Antibiotic biosynthesis; aclacinomycin biosynthesis.
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DR   EMBL; U77891; AAD04718.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9ZAU0; -.
DR   SMR; Q9ZAU0; -.
DR   KEGG; ag:AAD04718; -.
DR   BioCyc; MetaCyc:MON-18188; -.
DR   UniPathway; UPA00054; -.
DR   UniPathway; UPA01040; -.
DR   UniPathway; UPA01042; -.
DR   UniPathway; UPA01043; -.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:1901771; P:daunorubicin biosynthetic process; IMP:UniProtKB.
DR   Gene3D; 1.10.1200.10; -; 1.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   Pfam; PF00550; PP-binding; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   SUPFAM; SSF47336; SSF47336; 1.
DR   PROSITE; PS50075; CARRIER; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   3: Inferred from homology;
KW   Antibiotic biosynthesis; Phosphopantetheine; Phosphoprotein.
FT   CHAIN           1..84
FT                   /note="Anthracycline acyl carrier protein DpsG"
FT                   /id="PRO_0000425717"
FT   DOMAIN          3..80
FT                   /note="Carrier"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   MOD_RES         40
FT                   /note="O-(pantetheine 4'-phosphoryl)serine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
SQ   SEQUENCE   84 AA;  9395 MW;  1984CDA5563446B9 CRC64;
     MAELSLAELR EIMRQSLGED EVPDLADADT VTFEDLGLDS LAVLETVNHI ERTYGVKLPE
     EELAEVRTPH SMLIFVNERL RAAA