ID   DPSG_STRS5              Reviewed;          84 AA.
AC   Q53878;
DT   19-MAR-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Anthracycline acyl carrier protein DauA;
GN   Name=dauA; Synonyms=OrfG;
OS   Streptomyces sp. (strain C5).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=45212;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=C5;
RX   PubMed=8655529; DOI=10.1128/jb.178.11.3384-3388.1996;
RA   Dickens M.L., Ye J., Strohl W.R.;
RT   "Cloning, sequencing, and analysis of aklaviketone reductase from
RT   Streptomyces sp. strain C5.";
RL   J. Bacteriol. 178:3384-3388(1996).
RN   [2]
RP   FUNCTION.
RC   STRAIN=C5;
RX   PubMed=9098068; DOI=10.1128/jb.179.8.2690-2696.1997;
RA   Rajgarhia V.B., Strohl W.R.;
RT   "Minimal Streptomyces sp. strain C5 daunorubicin polyketide biosynthesis
RT   genes required for aklanonic acid biosynthesis.";
RL   J. Bacteriol. 179:2690-2696(1997).
CC   -!- FUNCTION: Involved in the biosynthesis of aklanonate which is an
CC       important precursor common to the formation of the clinically
CC       significant anthracyclines such as carminomycin, daunorubicin
CC       (daunomycin), rhodomycin, aclacinomycin T (aklavin) and aclacinomycin A
CC       (aclarubicin). These compounds are aromatic polyketide antibiotics that
CC       exhibit high cytotoxicity and are widely applied in the chemotherapy of
CC       a variety of cancers. {ECO:0000269|PubMed:9098068}.
CC   -!- PATHWAY: Antibiotic biosynthesis; daunorubicin biosynthesis.
CC   -!- PATHWAY: Antibiotic biosynthesis; carminomycin biosynthesis.
CC   -!- PATHWAY: Antibiotic biosynthesis; rhodomycin biosynthesis.
CC   -!- PATHWAY: Antibiotic biosynthesis; aclacinomycin biosynthesis.
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DR   EMBL; U43704; AAB08017.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q53878; -.
DR   SMR; Q53878; -.
DR   UniPathway; UPA00054; -.
DR   UniPathway; UPA01040; -.
DR   UniPathway; UPA01042; -.
DR   UniPathway; UPA01043; -.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:1901771; P:daunorubicin biosynthetic process; IMP:UniProtKB.
DR   Gene3D; 1.10.1200.10; -; 1.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   Pfam; PF00550; PP-binding; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   SUPFAM; SSF47336; SSF47336; 1.
DR   PROSITE; PS50075; CARRIER; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   3: Inferred from homology;
KW   Antibiotic biosynthesis; Phosphopantetheine; Phosphoprotein.
FT   CHAIN           1..84
FT                   /note="Anthracycline acyl carrier protein DauA"
FT                   /id="PRO_0000425718"
FT   DOMAIN          3..80
FT                   /note="Carrier"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   MOD_RES         40
FT                   /note="O-(pantetheine 4'-phosphoryl)serine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
SQ   SEQUENCE   84 AA;  9437 MW;  0694DBC9863446B9 CRC64;
     MAELSLAELR EIMRQSLGED EVPDLADADT VTFEDLGLDS LAVLETVNHI ERTYGVKLPE
     EELAEIRTPH SMLIFVNERL RAAV