ID   ADER_BACSU              Reviewed;         422 AA.
AC   P71073; Q795L1;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 2.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=DNA-binding transcriptional activator AdeR;
DE   AltName: Full=PucR-type transcriptional activator AdeR;
GN   Name=adeR {ECO:0000303|PubMed:22797752}; Synonyms=yukF;
GN   OrderedLocusNames=BSU31920;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9168598; DOI=10.1099/00221287-143-5-1489;
RA   Oudega B., Vandenbol M., Koningstein G.;
RT   "A 12kb nucleotide sequence containing the alanine dehydrogenase gene at
RT   279 degree on the Bacillus subtilis chromosome.";
RL   Microbiology 143:1489-1491(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   SEQUENCE REVISION TO C-TERMINUS.
RX   PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA   Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA   Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT   "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT   168 reference genome a decade later.";
RL   Microbiology 155:1758-1775(2009).
RN   [4]
RP   FUNCTION, DISRUPTION PHENOTYPE, NOMENCLATURE, AND DNA-BINDING.
RC   STRAIN=168;
RX   PubMed=22797752; DOI=10.1128/jb.00778-12;
RA   Lin T.H., Wei G.T., Su C.C., Shaw G.C.;
RT   "AdeR, a PucR-type transcription factor, activates expression of L-alanine
RT   dehydrogenase and is required for sporulation of Bacillus subtilis.";
RL   J. Bacteriol. 194:4995-5001(2012).
CC   -!- FUNCTION: Activates ald expression in response to alanine availability
CC       and is important for normal sporulation in B.subtilis.
CC       {ECO:0000269|PubMed:22797752}.
CC   -!- DISRUPTION PHENOTYPE: Disruption of adeR causes a sporulation defect.
CC       {ECO:0000269|PubMed:22797752}.
CC   -!- SIMILARITY: Belongs to the CdaR family. {ECO:0000305}.
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DR   EMBL; Z82015; CAB04774.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB15180.2; -; Genomic_DNA.
DR   PIR; H70013; H70013.
DR   RefSeq; NP_391070.2; NC_000964.3.
DR   RefSeq; WP_010886604.1; NZ_JNCM01000033.1.
DR   AlphaFoldDB; P71073; -.
DR   SMR; P71073; -.
DR   STRING; 224308.BSU31920; -.
DR   PaxDb; P71073; -.
DR   PRIDE; P71073; -.
DR   EnsemblBacteria; CAB15180; CAB15180; BSU_31920.
DR   GeneID; 938860; -.
DR   KEGG; bsu:BSU31920; -.
DR   PATRIC; fig|224308.43.peg.3341; -.
DR   eggNOG; COG2508; Bacteria.
DR   eggNOG; COG4465; Bacteria.
DR   InParanoid; P71073; -.
DR   OMA; VAISIWK; -.
DR   PhylomeDB; P71073; -.
DR   BioCyc; BSUB:BSU31920-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0043934; P:sporulation; IMP:UniProtKB.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IMP:UniProtKB.
DR   Gene3D; 1.10.10.2840; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   InterPro; IPR041522; CdaR_GGDEF.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR010312; GTP_sensing_CodY_N.
DR   InterPro; IPR025736; PucR_C-HTH_dom.
DR   InterPro; IPR042070; PucR_C-HTH_sf.
DR   Pfam; PF06018; CodY; 1.
DR   Pfam; PF17853; GGDEF_2; 1.
DR   Pfam; PF13556; HTH_30; 1.
PE   1: Evidence at protein level;
KW   Activator; DNA-binding; Reference proteome; Sporulation; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..422
FT                   /note="DNA-binding transcriptional activator AdeR"
FT                   /id="PRO_0000360161"
FT   CONFLICT        417..422
FT                   /note="LRHMDL -> PSGTWICEISQIHVFLFS (in Ref. 1; CAB04774)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   422 AA;  49020 MW;  1F8936A4B162ECBE CRC64;
     MSKRNQARKV GRFMTMPNDP FKYSFDRLED VADHISDVLR CPITIEDVNH KLLAYSTHSD
     CTDPARTSTI IGRRVPEKVI NKLWKDGTIP ALLKTDQPIR VKQIDEVGLS NRVAISIWKN
     KQVLGFIWAL EIQKTLSDED LLTLQMAAKA VKNKLLKLQI RKTKNEERSQ EFFWKMLTGH
     IHQEDDMADG FHKLGMAAPS EFSVMIIRIN GELTEKIEQQ LQYLQETTQQ VYVLLATVDS
     NELIILTSPK TDHPFQDLKQ FALSTQKQLK ERYKIEDVSI AFGGIYNSIS FVSRSYQEAL
     SVLKTKERFA EETKHLFSFS ELGIYQYLDV LNEKRKQAGH YNYSLSKLEQ YDRDHQSNMV
     ETLERFIEAD SNVNTASKLL NIHVNTLNYR LKRISQIAEI DLKNVNQKFT IYLDIKLRHM
     DL