ID   ADET1_ACIBA             Reviewed;         304 AA.
AC   C7F8K6;
DT   05-DEC-2018, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 1.
DT   25-MAY-2022, entry version 15.
DE   RecName: Full=Probable solute-binding protein AdeT1 {ECO:0000305};
GN   Name=adeT1 {ECO:0000303|PubMed:21212056};
OS   Acinetobacter baumannii.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC   Acinetobacter; Acinetobacter calcoaceticus/baumannii complex.
OX   NCBI_TaxID=470;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=AC0037;
RX   PubMed=21212056; DOI=10.1093/jac/dkq469;
RA   Srinivasan V.B., Rajamohan G., Pancholi P., Marcon M., Gebreyes W.A.;
RT   "Molecular cloning and functional characterization of two novel membrane
RT   fusion proteins in conferring antimicrobial resistance in Acinetobacter
RT   baumannii.";
RL   J. Antimicrob. Chemother. 66:499-504(2011).
CC   -!- FUNCTION: Mediates antimicrobial resistance via active efflux.
CC       Contributes to resistance to antibiotics such as chloramphenicol,
CC       erythromycin and novobiocin (PubMed:21212056). May be part of a
CC       tripartite ATP-independent periplasmic (TRAP) transport system
CC       (Probable). {ECO:0000269|PubMed:21212056, ECO:0000305|PubMed:21212056}.
CC   -!- DISRUPTION PHENOTYPE: Deletion of the gene results in increased
CC       susceptibility to different antibiotics, dyes, detergents and
CC       disinfectants. {ECO:0000269|PubMed:21212056}.
CC   -!- SIMILARITY: Belongs to the bacterial solute-binding protein 7 family.
CC       {ECO:0000305}.
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DR   EMBL; GQ338837; ACU27398.1; -; Genomic_DNA.
DR   AlphaFoldDB; C7F8K6; -.
DR   SMR; C7F8K6; -.
DR   STRING; 470.IX87_20175; -.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.190.170; -; 1.
DR   InterPro; IPR045758; AdeT1/2.
DR   InterPro; IPR038404; TRAP_DctP_sf.
DR   Pfam; PF19582; DUF6091; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Transport.
FT   CHAIN           1..304
FT                   /note="Probable solute-binding protein AdeT1"
FT                   /id="PRO_0000445958"
SQ   SEQUENCE   304 AA;  33456 MW;  B84129969622418E CRC64;
     MFDPIGKSGD AFALAKDYAL EAKNWGADLS LKAYVDERVA AEDLKVGKCD GAIISGLRGR
     QFNKYTGSLD AVGALTNMKT AINAYKLLSS PMAAKNMVVG PYEIAGLGTI GPAYLFVNDR
     SINTLAKAAG KKIGVFKYDE AQPKLVQHVG GQAVSVDVTN AGAKFNNHEI DIVPAPIVAF
     KPFELYKGLG EKGAIVRFPL TQISADFIIR KDQFPAGFGQ KSRTWVASQL NRTFGIIAKY
     ESDIPSKYWM DIPKNEQLNY MKMMREARIQ LTKAGIYDPK MMNFLKKVRC KENPSNFECA
     LNDE