位置:首页 > 蛋白库 > DPS_ECOSM
DPS_ECOSM
ID   DPS_ECOSM               Reviewed;         167 AA.
AC   B1LMA4;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=DNA protection during starvation protein {ECO:0000255|HAMAP-Rule:MF_01441};
DE            EC=1.16.-.- {ECO:0000255|HAMAP-Rule:MF_01441};
GN   Name=dps {ECO:0000255|HAMAP-Rule:MF_01441}; OrderedLocusNames=EcSMS35_0836;
OS   Escherichia coli (strain SMS-3-5 / SECEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=439855;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SMS-3-5 / SECEC;
RX   PubMed=18708504; DOI=10.1128/jb.00661-08;
RA   Fricke W.F., Wright M.S., Lindell A.H., Harkins D.M., Baker-Austin C.,
RA   Ravel J., Stepanauskas R.;
RT   "Insights into the environmental resistance gene pool from the genome
RT   sequence of the multidrug-resistant environmental isolate Escherichia coli
RT   SMS-3-5.";
RL   J. Bacteriol. 190:6779-6794(2008).
CC   -!- FUNCTION: During stationary phase, binds the chromosome non-
CC       specifically, forming a highly ordered and stable dps-DNA co-crystal
CC       within which chromosomal DNA is condensed and protected from diverse
CC       damages. It protects DNA from oxidative damage by sequestering
CC       intracellular Fe(2+) ion and storing it in the form of Fe(3+)
CC       oxyhydroxide mineral, which can be released after reduction. One
CC       hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl
CC       radical production by the Fenton reaction. Dps also protects the cell
CC       from UV and gamma irradiation, iron and copper toxicity, thermal stress
CC       and acid and base shocks. Also shows a weak catalase activity.
CC       {ECO:0000255|HAMAP-Rule:MF_01441}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 Fe(2+) + 2 H(+) + H2O2 = 2 Fe(3+) + 2 H2O;
CC         Xref=Rhea:RHEA:48712, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16240, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01441};
CC   -!- SUBUNIT: Homododecamer. The 12 subunits form a hollow sphere into which
CC       the mineral iron core of up to 500 Fe(3+) can be deposited.
CC       {ECO:0000255|HAMAP-Rule:MF_01441}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000255|HAMAP-
CC       Rule:MF_01441}.
CC   -!- SIMILARITY: Belongs to the Dps family. {ECO:0000255|HAMAP-
CC       Rule:MF_01441}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000970; ACB17903.1; -; Genomic_DNA.
DR   RefSeq; WP_000100800.1; NC_010498.1.
DR   AlphaFoldDB; B1LMA4; -.
DR   SMR; B1LMA4; -.
DR   EnsemblBacteria; ACB17903; ACB17903; EcSMS35_0836.
DR   GeneID; 67413850; -.
DR   KEGG; ecm:EcSMS35_0836; -.
DR   HOGENOM; CLU_098183_1_2_6; -.
DR   OMA; DDYSIGR; -.
DR   Proteomes; UP000007011; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR   GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008199; F:ferric iron binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016722; F:oxidoreductase activity, acting on metal ions; IEA:InterPro.
DR   GO; GO:0006879; P:cellular iron ion homeostasis; IEA:UniProtKB-KW.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   CDD; cd01043; DPS; 1.
DR   Gene3D; 1.20.1260.10; -; 1.
DR   HAMAP; MF_01441; Dps; 1.
DR   InterPro; IPR002177; DPS_DNA-bd.
DR   InterPro; IPR023188; DPS_DNA-bd_CS.
DR   InterPro; IPR023067; Dps_gammaproteobac.
DR   InterPro; IPR012347; Ferritin-like.
DR   InterPro; IPR009078; Ferritin-like_SF.
DR   InterPro; IPR008331; Ferritin_DPS_dom.
DR   PANTHER; PTHR42932; PTHR42932; 1.
DR   Pfam; PF00210; Ferritin; 1.
DR   PIRSF; PIRSF005900; Dps; 1.
DR   PRINTS; PR01346; HELNAPAPROT.
DR   SUPFAM; SSF47240; SSF47240; 1.
DR   PROSITE; PS00818; DPS_1; 1.
DR   PROSITE; PS00819; DPS_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA condensation; DNA-binding; Iron; Iron storage;
KW   Metal-binding; Oxidoreductase.
FT   CHAIN           1..167
FT                   /note="DNA protection during starvation protein"
FT                   /id="PRO_1000145905"
FT   BINDING         51
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="1"
FT                   /ligand_note="ligand shared between two neighboring
FT                   subunits"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01441"
FT   BINDING         78
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="1"
FT                   /ligand_note="ligand shared between two neighboring
FT                   subunits"
FT                   /note="in other chain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01441"
FT   BINDING         82
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="1"
FT                   /ligand_note="ligand shared between two neighboring
FT                   subunits"
FT                   /note="in other chain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01441"
FT   BINDING         82
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01441"
SQ   SEQUENCE   167 AA;  18695 MW;  596A79B1C6A5E60B CRC64;
     MSTAKLVKSK ATNLLYTRND VSDSEKKATV ELLNRQVIQF IDLSLITKQA HWNMRGANFI
     AVHEMLDGFR TALIDHLDTM AERAVQLGGV ALGTTQVINS KTPLKSYPLD IHNVQDHLKE
     LADRYAIVAN DVRKAIGEAK DDDTADILTA ASRDLDKFLW FIESNIE
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024