ID   DPY13_CAEEL             Reviewed;         302 AA.
AC   P17657;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 2.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Cuticle collagen dpy-13;
DE   AltName: Full=Protein dumpy-13;
GN   Name=dpy-13; Synonyms=dpy-16; ORFNames=F30B5.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2846184; DOI=10.1016/0092-8674(88)90215-2;
RA   von Mende N., Bird D.M., Albert P.S., Riddle D.L.;
RT   "dpy-13: a nematode collagen gene that affects body shape.";
RL   Cell 55:567-576(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [3]
RP   MUTAGENESIS OF GLY-205.
RX   PubMed=1398138; DOI=10.1016/0378-1119(92)90102-u;
RA   Bird D.M.;
RT   "Sequence comparison of the Caenorhabditis elegans dpy-13 and col-34 genes,
RT   and their deduced collagen products.";
RL   Gene 120:261-266(1992).
CC   -!- FUNCTION: Nematode cuticles are composed largely of collagen-like
CC       proteins. The cuticle functions both as an exoskeleton and as a barrier
CC       to protect the worm from its environment. Mutations in dpy-13 affects
CC       the body shape.
CC   -!- SUBUNIT: Collagen polypeptide chains are complexed within the cuticle
CC       by disulfide bonds and other types of covalent cross-links.
CC   -!- SIMILARITY: Belongs to the cuticular collagen family. {ECO:0000305}.
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DR   EMBL; M23559; AAA27994.1; -; Genomic_DNA.
DR   EMBL; FO081259; CCD70270.1; -; Genomic_DNA.
DR   PIR; A31921; A31921.
DR   RefSeq; NP_500519.1; NM_068118.5.
DR   AlphaFoldDB; P17657; -.
DR   SMR; P17657; -.
DR   STRING; 6239.F30B5.1; -.
DR   EPD; P17657; -.
DR   PaxDb; P17657; -.
DR   PeptideAtlas; P17657; -.
DR   EnsemblMetazoa; F30B5.1.1; F30B5.1.1; WBGene00001074.
DR   GeneID; 177187; -.
DR   KEGG; cel:CELE_F30B5.1; -.
DR   UCSC; F30B5.1; c. elegans.
DR   CTD; 177187; -.
DR   WormBase; F30B5.1; CE04462; WBGene00001074; dpy-13.
DR   eggNOG; KOG3544; Eukaryota.
DR   HOGENOM; CLU_001074_4_2_1; -.
DR   InParanoid; P17657; -.
DR   OMA; CEGCCQP; -.
DR   OrthoDB; 1393043at2759; -.
DR   PhylomeDB; P17657; -.
DR   PRO; PR:P17657; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00001074; Expressed in material anatomical entity and 4 other tissues.
DR   GO; GO:0060102; C:collagen and cuticulin-based cuticle extracellular matrix; IDA:WormBase.
DR   GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR   GO; GO:0042302; F:structural constituent of cuticle; IEA:UniProtKB-KW.
DR   GO; GO:0042338; P:cuticle development involved in collagen and cuticulin-based cuticle molting cycle; IMP:WormBase.
DR   InterPro; IPR002486; Col_cuticle_N.
DR   InterPro; IPR008160; Collagen.
DR   Pfam; PF01484; Col_cuticle_N; 1.
DR   Pfam; PF01391; Collagen; 2.
DR   SMART; SM01088; Col_cuticle_N; 1.
PE   1: Evidence at protein level;
KW   Collagen; Cuticle; Disulfide bond; Reference proteome; Repeat.
FT   CHAIN           1..302
FT                   /note="Cuticle collagen dpy-13"
FT                   /id="PRO_0000127598"
FT   REGION          106..135
FT                   /note="Triple-helical region"
FT   REGION          108..284
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          154..210
FT                   /note="Triple-helical region"
FT   REGION          219..278
FT                   /note="Triple-helical region"
FT   COMPBIAS        110..159
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        246..260
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MUTAGEN         205
FT                   /note="G->E: In dpy13(E225)."
FT                   /evidence="ECO:0000269|PubMed:1398138"
SQ   SEQUENCE   302 AA;  30053 MW;  16B5CDAF14E0F0E5 CRC64;
     MDIDTKIKAY RFVAYSAVVF SVIAVLSVCI TLPIVYNYVH TVRRQLHNEA LTCKGSMKDV
     WADVHHLRVD AASNRTARAV RYGRDDAAAG NGPNFDSGCE GCCQPGPQGA PGAPGKPGRP
     GKPGAPGFPG NPGKAPQKPC EEITPPPCKP CPQGPPGAPG LPGDQGDKGE AGQPGQPGSD
     AAPGEQGPKG PNGAPGKPGA PGAPGDEGLP AVCEPVQKGE PGSTGEPGPV GPPGPSGQPG
     NDGTPGQPGP KGPPGPDGKP GADGNPGQPG PVGPPGTPGE RGICPKYCAI DGGIFFEDGT
     RR