ID   DPY20_CAEBR             Reviewed;         439 AA.
AC   P51558; A8X0X7; Q61SP5;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 2.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Protein dumpy-20;
GN   Name=dpy-20; ORFNames=CBG06089;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22.
RX   PubMed=7770042; DOI=10.1007/bf00293205;
RA   Clark D.V., Suleman D.S., Beckenbach K.A., Gilchrist E.J., Baillie D.L.;
RT   "Molecular cloning and characterization of the dpy-20 gene of
RT   Caenorhabditis elegans.";
RL   Mol. Gen. Genet. 247:367-378(1995).
CC   -!- FUNCTION: Involved in cuticle function and is essential for normal
CC       morphological development. {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; HE600986; CAP26287.1; -; Genomic_DNA.
DR   RefSeq; XP_002633346.1; XM_002633300.1.
DR   AlphaFoldDB; P51558; -.
DR   STRING; 6238.CBG06089; -.
DR   EnsemblMetazoa; CBG06089.1; CBG06089.1; WBGene00028421.
DR   GeneID; 8575343; -.
DR   KEGG; cbr:CBG_06089; -.
DR   CTD; 8575343; -.
DR   WormBase; CBG06089; CBP21693; WBGene00028421; Cbr-dpy-20.
DR   eggNOG; ENOG502TGV1; Eukaryota.
DR   HOGENOM; CLU_681947_0_0_1; -.
DR   InParanoid; P51558; -.
DR   OMA; MNDVGIR; -.
DR   OrthoDB; 913874at2759; -.
DR   Proteomes; UP000008549; Chromosome IV.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0042302; F:structural constituent of cuticle; IEA:UniProtKB-KW.
DR   InterPro; IPR003656; Znf_BED.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   Pfam; PF02892; zf-BED; 2.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS50808; ZF_BED; 2.
PE   3: Inferred from homology;
KW   Cuticle; Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger.
FT   CHAIN           1..439
FT                   /note="Protein dumpy-20"
FT                   /id="PRO_0000079994"
FT   ZN_FING         135..184
FT                   /note="BED-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT   ZN_FING         349..398
FT                   /note="BED-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT   REGION          93..116
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         154
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT   BINDING         157
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT   BINDING         172
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT   BINDING         177
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT   BINDING         368
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT   BINDING         371
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT   BINDING         386
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT   BINDING         391
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
SQ   SEQUENCE   439 AA;  49650 MW;  52551C14B2C020EE CRC64;
     MDGHSNTSVI LHTYQQQQSQ LIPSIIPQTL PDGYGLTTTI SQPDFSGTNA FINTNPWNTT
     TFPTYRDNQY TNEVSVLNYP TVYDDFSKES TAGTLSDPSL HGSNSSSSTS DVGSSVDCSI
     SPEPILMPCV KRGRPTENPC WAYFHRIDDQ LVKCRLCTKV VRSACATNMT KHLERHHTDD
     YQKVTGQLKL FRMNDAGIRS KMHYQVADTP LTPIPVLPNS YVLPKMDPME AFDASQYYTM
     QPDSTAINAQ PFPQFDQPQT SADSQTWPLT HFWPNGAQNN MMPQLGEPST SAIGASVIQE
     IRKLNLDSDQ KRLELEMDQN RRLLLAQKAD EKGRVVKTTT KPYQKRNRKT EHPVWAFFKR
     TGDGNAECII CQGVVKSPCS SNFMRHLMRH HSTEYNDVYL KWIEKRNVTH PGIHCTSVPP
     PISFPNKDNV RTEPIFTVK