ID   DPY30_BOVIN             Reviewed;          99 AA.
AC   Q2NKU6;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Protein dpy-30 homolog;
DE   AltName: Full=Dpy-30-like protein;
DE            Short=Dpy-30L;
GN   Name=DPY30;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: As part of the MLL1/MLL complex, involved in the methylation
CC       of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-
CC       4' methylation represents a specific tag for epigenetic transcriptional
CC       activation. May play some role in histone H3 acetylation. In embryonic
CC       stem cells, may play a crucial role in retinoic acid-induced
CC       differentiation along the neural lineage, regulating gene induction and
CC       H3 'Lys-4' methylation at key developmental loci. May also play an
CC       indirect or direct role in endosomal transport (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Core component of several methyltransferase-
CC       containing complexes including MLL1/MLL, MLL2/3 (also named ASCOM
CC       complex) and MLL4/WBP7. Each complex is at least composed of ASH2L,
CC       RBBP5, WDR5, DPY30, one or more specific histone methyltransferases
CC       (KMT2A/MLL1, KMT2D/MLL2, KMT2C/MLL3 and KMT2B/MLL4), and the
CC       facultative components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP,
CC       PAGR1 and alpha- and beta-tubulin (By similarity). Interacts with
CC       ASH2L; the interaction is direct (By similarity). Interacts with
CC       ARFGEF1 (By similarity). Component of the SET1 complex, at least
CC       composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82,
CC       RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Golgi apparatus, trans-
CC       Golgi network {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the dpy-30 family. {ECO:0000305}.
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DR   EMBL; BC111634; AAI11635.1; -; mRNA.
DR   RefSeq; NP_001071384.1; NM_001077916.2.
DR   RefSeq; XP_010808171.1; XM_010809869.1.
DR   AlphaFoldDB; Q2NKU6; -.
DR   SMR; Q2NKU6; -.
DR   STRING; 9913.ENSBTAP00000012183; -.
DR   PaxDb; Q2NKU6; -.
DR   PRIDE; Q2NKU6; -.
DR   Ensembl; ENSBTAT00000012183; ENSBTAP00000012183; ENSBTAG00000009246.
DR   GeneID; 513162; -.
DR   KEGG; bta:513162; -.
DR   CTD; 84661; -.
DR   VEuPathDB; HostDB:ENSBTAG00000009246; -.
DR   VGNC; VGNC:50608; DPY30.
DR   eggNOG; KOG4109; Eukaryota.
DR   GeneTree; ENSGT00390000008808; -.
DR   HOGENOM; CLU_135823_3_1_1; -.
DR   InParanoid; Q2NKU6; -.
DR   OMA; METPHEK; -.
DR   OrthoDB; 1596051at2759; -.
DR   Reactome; R-BTA-3214841; PKMTs methylate histone lysines.
DR   Reactome; R-BTA-8936459; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function.
DR   Proteomes; UP000009136; Chromosome 11.
DR   Bgee; ENSBTAG00000009246; Expressed in oocyte and 104 other tissues.
DR   GO; GO:0035097; C:histone methyltransferase complex; ISS:UniProtKB.
DR   GO; GO:0071339; C:MLL1 complex; IEA:Ensembl.
DR   GO; GO:0044666; C:MLL3/4 complex; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0048188; C:Set1C/COMPASS complex; ISS:UniProtKB.
DR   GO; GO:0005802; C:trans-Golgi network; ISS:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0016197; P:endosomal transport; ISS:UniProtKB.
DR   GO; GO:0051568; P:histone H3-K4 methylation; ISS:UniProtKB.
DR   InterPro; IPR007858; Dpy-30_motif.
DR   InterPro; IPR037856; Sdc1/DPY30.
DR   PANTHER; PTHR23356; PTHR23356; 1.
DR   Pfam; PF05186; Dpy-30; 1.
PE   3: Inferred from homology;
KW   Acetylation; Chromatin regulator; Golgi apparatus; Isopeptide bond;
KW   Nucleus; Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation; Ubl conjugation.
FT   CHAIN           1..99
FT                   /note="Protein dpy-30 homolog"
FT                   /id="PRO_0000247554"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9C005"
FT   MOD_RES         19
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9C005"
FT   MOD_RES         35
FT                   /note="N6-acetyllysine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:Q9C005"
FT   CROSSLNK        35
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2); alternate"
FT                   /evidence="ECO:0000250|UniProtKB:Q9C005"
SQ   SEQUENCE   99 AA;  11250 MW;  5356AC515B9C2ADB CRC64;
     MEPEQMLEGQ TQVAENPHSE YGLTDNVERI VENEKINAEK SSKQKVDLQS LPTRAYLDQT
     VVPILLQGLA VLAKERPPNP IEFLASYLLK NKAQFEDRN