DPY30_DROME
ID DPY30_DROME Reviewed; 134 AA.
AC Q9VKQ9; B3DMX8;
DT 11-JUN-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Protein dpy-30 homolog {ECO:0000250|UniProtKB:Q9C005};
DE AltName: Full=Dpy-30-like protein 1 {ECO:0000312|EMBL:AAF53001.1};
GN Name=Dpy-30L1 {ECO:0000312|EMBL:AAF53001.1,
GN ECO:0000312|FlyBase:FBgn0032293}; ORFNames=CG6444;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000312|EMBL:AAF53001.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000312|EMBL:AAF53001.1}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:ACD81780.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.;
RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000305}
RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=18588663; DOI=10.1186/1471-213x-8-68;
RA Vardanyan A., Atanesyan L., Egli D., Raja S.J., Steinmann-Zwicky M.,
RA Renkawitz-Pohl R., Georgiev O., Schaffner W.;
RT "Dumpy-30 family members as determinants of male fertility and interaction
RT partners of metal-responsive transcription factor 1 (MTF-1) in
RT Drosophila.";
RL BMC Dev. Biol. 8:68-68(2008).
RN [5] {ECO:0000305}
RP FUNCTION, IDENTIFICATION IN THE SET1 COMPLEX, AND SUBCELLULAR LOCATION.
RX PubMed=21694722; DOI=10.1038/emboj.2011.194;
RA Ardehali M.B., Mei A., Zobeck K.L., Caron M., Lis J.T., Kusch T.;
RT "Drosophila Set1 is the major histone H3 lysine 4 trimethyltransferase with
RT role in transcription.";
RL EMBO J. 30:2817-2828(2011).
RN [6] {ECO:0000305}
RP FUNCTION, AND IDENTIFICATION IN THE SET1 AND MLL3/4 COMPLEXES.
RX PubMed=21875999; DOI=10.1128/mcb.06092-11;
RA Mohan M., Herz H.M., Smith E.R., Zhang Y., Jackson J., Washburn M.P.,
RA Florens L., Eissenberg J.C., Shilatifard A.;
RT "The COMPASS family of H3K4 methylases in Drosophila.";
RL Mol. Cell. Biol. 31:4310-4318(2011).
CC -!- FUNCTION: Component of the SET1 complex that specifically di- and
CC trimethylates 'Lys-4' of histone H3 and of the MLL3/4 complex which
CC also methylates histone H3 'Lys-4'. Inhibits MTF-1 transcription factor
CC activity. {ECO:0000269|PubMed:18588663, ECO:0000269|PubMed:21694722,
CC ECO:0000269|PubMed:21875999}.
CC -!- SUBUNIT: Core component of several methyltransferase-containing
CC complexes. Component of the SET1 complex, composed at least of the
CC catalytic subunit Set1, wds/WDR5, Wdr82, Rbbp5, ash2, Cfp1/CXXC1, hcf
CC and Dpy-30L1. Component of the MLL3/4 complex composed at least of the
CC catalytic subunit trr, ash2, Rbbp5, Dpy-30L1, wds, hcf, ptip, Pa1, Utx,
CC Lpt and Ncoa6. {ECO:0000269|PubMed:21694722,
CC ECO:0000269|PubMed:21875999}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21694722}.
CC -!- TISSUE SPECIFICITY: Expressed in larval brain, gonad, imaginal disk and
CC salivary gland and in adult brain, testis, ovary and salivary gland.
CC {ECO:0000269|PubMed:18588663}.
CC -!- DISRUPTION PHENOTYPE: Viable and fertile with no overt disruption of
CC metal homeostasis. {ECO:0000269|PubMed:18588663}.
CC -!- SIMILARITY: Belongs to the dpy-30 family. {ECO:0000255}.
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DR EMBL; AE014134; AAF53001.1; -; Genomic_DNA.
DR EMBL; BT032766; ACD81780.2; -; mRNA.
DR RefSeq; NP_609445.1; NM_135601.4.
DR AlphaFoldDB; Q9VKQ9; -.
DR SMR; Q9VKQ9; -.
DR BioGRID; 60554; 10.
DR IntAct; Q9VKQ9; 7.
DR MINT; Q9VKQ9; -.
DR STRING; 7227.FBpp0079701; -.
DR PaxDb; Q9VKQ9; -.
DR PRIDE; Q9VKQ9; -.
DR DNASU; 34480; -.
DR EnsemblMetazoa; FBtr0080112; FBpp0079701; FBgn0032293.
DR GeneID; 34480; -.
DR KEGG; dme:Dmel_CG6444; -.
DR UCSC; CG6444-RA; d. melanogaster.
DR CTD; 34480; -.
DR FlyBase; FBgn0032293; Dpy-30L1.
DR VEuPathDB; VectorBase:FBgn0032293; -.
DR eggNOG; KOG4109; Eukaryota.
DR GeneTree; ENSGT00940000173866; -.
DR HOGENOM; CLU_135823_1_0_1; -.
DR InParanoid; Q9VKQ9; -.
DR OMA; KHSNGCD; -.
DR OrthoDB; 1596051at2759; -.
DR PhylomeDB; Q9VKQ9; -.
DR Reactome; R-DME-8936459; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function.
DR BioGRID-ORCS; 34480; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 34480; -.
DR PRO; PR:Q9VKQ9; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0032293; Expressed in egg cell and 20 other tissues.
DR Genevisible; Q9VKQ9; DM.
DR GO; GO:0044665; C:MLL1/2 complex; ISS:FlyBase.
DR GO; GO:0044666; C:MLL3/4 complex; IDA:FlyBase.
DR GO; GO:0048188; C:Set1C/COMPASS complex; IDA:FlyBase.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0051568; P:histone H3-K4 methylation; IDA:FlyBase.
DR InterPro; IPR007858; Dpy-30_motif.
DR InterPro; IPR037856; Sdc1/DPY30.
DR PANTHER; PTHR23356; PTHR23356; 1.
DR Pfam; PF05186; Dpy-30; 1.
PE 1: Evidence at protein level;
KW Chromatin regulator; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..134
FT /note="Protein dpy-30 homolog"
FT /id="PRO_0000429379"
FT REGION 1..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..81
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 134 AA; 13794 MW; 0A9E18CA132E9A57 CRC64;
MEAKTDAPIS PAPTTNPPAE AGKEPNASSN AQANPTAAPG APPSGAIAVG QSTNPVAQQQ
QQPAVAKKPS SETNNMPTRQ YLDQTVAPVL LHGMQALARE RPTDPIQFLA SYLLKHSNGC
DENNASAAAV DNNS
