DPY5_CAEEL
ID DPY5_CAEEL Reviewed; 284 AA.
AC P91285;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Cuticle collagen dpy-5;
DE AltName: Full=Protein dumpy-5;
GN Name=dpy-5; ORFNames=F27C1.8;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP IDENTIFICATION.
RA Thacker C.M., Rose A.M.;
RT "dpy-5 encodes a cuticle collagen.";
RL (er) Worm Breeder's Gazette 15(1):54(1997).
CC -!- FUNCTION: Nematode cuticles are composed largely of collagen-like
CC proteins. The cuticle functions both as an exoskeleton and as a barrier
CC to protect the worm from its environment.
CC -!- SUBUNIT: Collagen polypeptide chains are complexed within the cuticle
CC by disulfide bonds and other types of covalent cross-links.
CC {ECO:0000250}.
CC -!- PTM: May be a substrate of bli-4.
CC -!- SIMILARITY: Belongs to the cuticular collagen family. {ECO:0000305}.
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DR EMBL; FO080736; CCD66289.1; -; Genomic_DNA.
DR PIR; T29528; T29528.
DR RefSeq; NP_491595.1; NM_059194.4.
DR AlphaFoldDB; P91285; -.
DR STRING; 6239.F27C1.8; -.
DR EPD; P91285; -.
DR PaxDb; P91285; -.
DR PeptideAtlas; P91285; -.
DR EnsemblMetazoa; F27C1.8.1; F27C1.8.1; WBGene00001067.
DR GeneID; 172197; -.
DR KEGG; cel:CELE_F27C1.8; -.
DR UCSC; F27C1.8.1; c. elegans.
DR CTD; 172197; -.
DR WormBase; F27C1.8; CE09720; WBGene00001067; dpy-5.
DR eggNOG; KOG3544; Eukaryota.
DR HOGENOM; CLU_001074_4_3_1; -.
DR InParanoid; P91285; -.
DR OMA; QYVRGIF; -.
DR OrthoDB; 1338933at2759; -.
DR PhylomeDB; P91285; -.
DR PRO; PR:P91285; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00001067; Expressed in material anatomical entity and 3 other tissues.
DR GO; GO:0060102; C:collagen and cuticulin-based cuticle extracellular matrix; IDA:WormBase.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0042329; F:structural constituent of collagen and cuticulin-based cuticle; IDA:WormBase.
DR GO; GO:0040002; P:collagen and cuticulin-based cuticle development; IMP:WormBase.
DR GO; GO:0042338; P:cuticle development involved in collagen and cuticulin-based cuticle molting cycle; IMP:WormBase.
DR GO; GO:0040032; P:post-embryonic body morphogenesis; IMP:WormBase.
DR GO; GO:0040014; P:regulation of multicellular organism growth; IMP:WormBase.
DR InterPro; IPR002486; Col_cuticle_N.
DR Pfam; PF01484; Col_cuticle_N; 1.
DR SMART; SM01088; Col_cuticle_N; 1.
PE 3: Inferred from homology;
KW Collagen; Cuticle; Disulfide bond; Reference proteome; Repeat.
FT CHAIN 1..284
FT /note="Cuticle collagen dpy-5"
FT /id="PRO_0000127597"
FT REGION 88..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 94..126
FT /note="Triple-helical region"
FT REGION 143..270
FT /note="Triple-helical region"
SQ SEQUENCE 284 AA; 28216 MW; 8EED98AED554B454 CRC64;
MVKAVVGFGA ACGISAIVAC LWAALVITND INDMYDDVMG ELGGFRDISD DTWGTLLDVR
HGAGESAEQY VRGIFGRHKR SNSQCSCGLP SQGCPAGAPG NPGAPGEPGG TGPDGKNGPT
GLPGLNIPIP NDFPKECIKC PAGPPGQDGL PGQEGFQGLP GDAGKRGTPG KDGEPGRVGD
IGDQGTPGQD GQPGLAGPPG RDGLTGKGQP GVAGRPGMPG PRGEPGNNGN PGEEGQTGAQ
GPTGQPGKDG FNGNDGTPGQ AGPQGAVGAD AEYCPCPERK RRRV
