DPY7_CAEEL
ID DPY7_CAEEL Reviewed; 318 AA.
AC P34688;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Cuticle collagen dpy-7;
DE AltName: Full=Protein dumpy-7;
DE Flags: Precursor;
GN Name=dpy-7; ORFNames=F46C8.6;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND MUTAGENESIS OF GLY-101; GLY-156;
RP GLY-189 AND GLY-201.
RX PubMed=1396579; DOI=10.1002/j.1460-2075.1992.tb05478.x;
RA Johnstone I.L., Shafi Y., Barry J.D.;
RT "Molecular analysis of mutations in the Caenorhabditis elegans collagen
RT gene dpy-7.";
RL EMBO J. 11:3857-3863(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Nematode cuticles are composed largely of collagen-like
CC proteins. The cuticle functions both as an exoskeleton and as a barrier
CC to protect the worm from its environment. Mutations in dpy-7 affects
CC the body shape.
CC -!- SUBUNIT: Collagen polypeptide chains are complexed within the cuticle
CC by disulfide bonds and other types of covalent cross-links.
CC -!- SIMILARITY: Belongs to the cuticular collagen family. {ECO:0000305}.
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DR EMBL; X64435; CAA45773.1; -; Genomic_DNA.
DR EMBL; FO081392; CCD71295.1; -; Genomic_DNA.
DR PIR; S27977; S27977.
DR RefSeq; NP_509274.1; NM_076873.4.
DR AlphaFoldDB; P34688; -.
DR BioGRID; 45937; 4.
DR IntAct; P34688; 1.
DR STRING; 6239.F46C8.6; -.
DR EPD; P34688; -.
DR PaxDb; P34688; -.
DR PeptideAtlas; P34688; -.
DR PRIDE; P34688; -.
DR EnsemblMetazoa; F46C8.6.1; F46C8.6.1; WBGene00001069.
DR GeneID; 181013; -.
DR KEGG; cel:CELE_F46C8.6; -.
DR UCSC; F46C8.6.1; c. elegans.
DR CTD; 181013; -.
DR WormBase; F46C8.6; CE04580; WBGene00001069; dpy-7.
DR eggNOG; KOG3544; Eukaryota.
DR GeneTree; ENSGT00970000196241; -.
DR HOGENOM; CLU_001074_4_0_1; -.
DR InParanoid; P34688; -.
DR OMA; CTSCVQL; -.
DR OrthoDB; 1446957at2759; -.
DR PhylomeDB; P34688; -.
DR PRO; PR:P34688; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00001069; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0060108; C:annular furrow extracellular matrix; IDA:WormBase.
DR GO; GO:0060102; C:collagen and cuticulin-based cuticle extracellular matrix; IDA:WormBase.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0042329; F:structural constituent of collagen and cuticulin-based cuticle; IDA:WormBase.
DR GO; GO:0042338; P:cuticle development involved in collagen and cuticulin-based cuticle molting cycle; IMP:WormBase.
DR GO; GO:0040032; P:post-embryonic body morphogenesis; IMP:WormBase.
DR InterPro; IPR002486; Col_cuticle_N.
DR InterPro; IPR008160; Collagen.
DR Pfam; PF01484; Col_cuticle_N; 1.
DR Pfam; PF01391; Collagen; 2.
DR SMART; SM01088; Col_cuticle_N; 1.
PE 1: Evidence at protein level;
KW Collagen; Cuticle; Disulfide bond; Reference proteome; Repeat; Signal.
FT SIGNAL 1..?
FT /evidence="ECO:0000255"
FT CHAIN ?..318
FT /note="Cuticle collagen dpy-7"
FT /id="PRO_0000006429"
FT REGION 101..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 101..130
FT /note="Triple-helical region"
FT REGION 147..206
FT /note="Triple-helical region"
FT REGION 209..235
FT /note="Triple-helical region"
FT REGION 240..278
FT /note="Triple-helical region"
FT COMPBIAS 215..229
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..270
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 101
FT /note="G->R: In dpy7(SC27)."
FT /evidence="ECO:0000269|PubMed:1396579"
FT MUTAGEN 156
FT /note="G->R: In dpy7(E88)."
FT /evidence="ECO:0000269|PubMed:1396579"
FT MUTAGEN 189
FT /note="G->Y: In dpy7(E1234)."
FT /evidence="ECO:0000269|PubMed:1396579"
FT MUTAGEN 201
FT /note="G->R: In dpy7(M38)."
FT /evidence="ECO:0000269|PubMed:1396579"
SQ SEQUENCE 318 AA; 31629 MW; 4EA66DA5FDC5737C CRC64;
MEKPSSGANH VAKATVSLSI ASVLILGAVL TMLSIQLDEA HERLQNRMGS FKFVARNIWH
DIVLVKSNGR IKRQYGGYGS DSAQSDNQQC TSCVQLRCPP GPIGPPGVSG EPGMDGANGR
PGKPGLDGLD VPLDPEPAFP CVICPAGPPG TRGPQGEVGR PGQTGESGHP GLPGRPGKPG
RVGDAGPQGE PGEQGEPGIK GPPGDDSIGG TGIKGPPGPP GPRGPKGPPG SNGLPSQNSG
PPGPIGEMGP PGPPGPRGEP GPPGPFGPPG DSGEPGGHCP SSCGVQEIVA PSVSELDTND
EPEKPARGGY SGGGYGKK
