DQA1_HUMAN
ID DQA1_HUMAN Reviewed; 254 AA.
AC P01909; O19630; O19706; P01907; P01908; P04225; P04226; P05536; P79553;
AC Q06751; Q29876; Q29994; Q2Q6Y6; Q2Q6Y7; Q2Q6Y8; Q2WCM3; Q30064; Q30067;
AC Q30068; Q30070; Q30071; Q30072; Q30073; Q30086; Q30101; Q5Y7D5; Q5Y7F5;
AC Q6ICU6; Q6PR46; Q6QDB1; Q860W2; Q860W4; Q9BD37; Q9TPM3; Q9UM31;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 03-AUG-2022, entry version 201.
DE RecName: Full=HLA class II histocompatibility antigen, DQ alpha 1 chain;
DE AltName: Full=DC-1 alpha chain;
DE AltName: Full=DC-alpha;
DE AltName: Full=HLA-DCA;
DE AltName: Full=MHC class II DQA1;
DE Flags: Precursor;
GN Name=HLA-DQA1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQA1*02:01).
RX PubMed=6415485; DOI=10.1038/305813a0;
RA Chang H.-C., Moriuchi T., Silver J.;
RT "The heavy chain of human B-cell alloantigen HLA-DS has a variable N-
RT terminal region and a constant immunoglobulin-like region.";
RL Nature 305:813-815(1983).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQA1*05:01).
RX PubMed=6585297; DOI=10.1002/j.1460-2075.1984.tb01826.x;
RA Schenning L., Larhammar D., Bill P., Wiman K., Jonsson A.-K., Rask L.,
RA Peterson P.A.;
RT "Both alpha and beta chains of HLA-DC class II histocompatibility antigens
RT display extensive polymorphism in their amino-terminal domains.";
RL EMBO J. 3:447-452(1984).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELES DQA1*01:02 AND ALLELE DQA1*03:01).
RX PubMed=6584734; DOI=10.1038/308327a0;
RA Auffray C., Lillie J.W., Arnot D., Grossberger D., Kappes D.,
RA Strominger J.L.;
RT "Isotypic and allotypic variation of human class II histocompatibility
RT antigen alpha-chain genes.";
RL Nature 308:327-333(1984).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQA1*05:01).
RX PubMed=3584986;
RA Schiffenbauer J., Didier D.K., Klearman M., Rice K., Shuman S.,
RA Tieber V.L., Kittlesen D.J., Schwartz B.D.;
RT "Complete sequence of the HLA DQ alpha and DQ beta cDNA from a DR5/DQw3
RT cell line.";
RL J. Immunol. 139:228-233(1987).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DQA1*05:01).
RX PubMed=9271631; DOI=10.1007/s002510050295;
RA Ellis M.C., Hetisimer A.H., Ruddy D.A., Hansen S.L., Kronmal G.S.,
RA McClelland E., Quintana L., Drayna D.T., Aldrich M.S., Mignot E.;
RT "HLA class II haplotype and sequence analysis support a role for DQ in
RT narcolepsy.";
RL Immunogenetics 46:410-417(1997).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES DQA1*01:01; DQA1*01:02 AND
RP DQA1*03:01).
RX PubMed=16140993; DOI=10.1101/gr.3554305;
RA Raymond C.K., Kas A., Paddock M., Qiu R., Zhou Y., Subramanian S.,
RA Chang J., Palmieri A., Haugen E., Kaul R., Olson M.V.;
RT "Ancient haplotypes of the HLA Class II region.";
RL Genome Res. 15:1250-1257(2005).
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES DQA1*01:02; DQA1*05:06;
RP DQA1*05:07 AND DQA1*05:08).
RX PubMed=16866887; DOI=10.1111/j.1399-0039.2006.00645.x;
RA Lee K.W., Jung Y.A., Oh D.H.;
RT "Four novel human leukocyte antigen-DQA1 alleles identified in the Korean
RT population.";
RL Tissue Antigens 68:167-172(2006).
RN [8]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DQA1*03:01).
RX PubMed=3036828; DOI=10.1016/s0021-9258(18)47482-0;
RA Jonsson A.-K., Hyldig-Nielsen J.-J., Servenius B., Larhammar D.,
RA Andersson G., Joergensen F., Peterson P.A., Rask L.;
RT "Class II genes of the human major histocompatibility complex. Comparisons
RT of the DQ and DX alpha and beta genes.";
RL J. Biol. Chem. 262:8767-8777(1987).
RN [9]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DQA1*01:01).
RA Ashdown M.L., Leas L., Gavrilidis A., Wood J.M., Simons M.J.;
RT "Identification of a novel DQA1 allele, DQA1*01012, and confirmatory
RT sequence of DQA1*01011.";
RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN [10]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE DQA1*02:01).
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN [11]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES DQA1*01:02 AND DQA1*05:09).
RA Voorter C.E., van den Berg-Loonen E.M.;
RT "New and confirmatory HLA sequences by SBT.";
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [12]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE DQA1*01:01).
RC TISSUE=Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [13]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELES DQA1*01:02;
RP DQA1*03:01 AND DQA1*05:01).
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [14]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELES DQA1*03:01 AND DQA1*05:01).
RC TISSUE=Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [15]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-27 (ALLELES
RP DQA1*01:01/DQA1*01:02/DQA1*01:03; DQA1*01:04; DQA1*01:05;
RP DQA1*02:01/DQA1*03:01/DQA1*03:03; DQA1*04:01/DQA1*06:01 AND
RP DQA1*05:01/DQA1*05:03/DQA1*05:05).
RC TISSUE=B-cell;
RA Yasunaga S., Kimura A., Sasazuki T.;
RT "Sequence polymorphisms in HLA-DQA1 exon1.";
RL Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases.
RN [16]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 19-254 (ALLELE DQA1*03:02).
RX PubMed=3879967; DOI=10.1073/pnas.82.10.3420;
RA Moriuchi J., Moriuchi T., Silver J.;
RT "Nucleotide sequence of an HLA-DQ alpha chain derived from a DRw9 cell
RT line: genetic and evolutionary implications.";
RL Proc. Natl. Acad. Sci. U.S.A. 82:3420-3424(1985).
RN [17]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 23-254 (ALLELE DQA1*01:02).
RX PubMed=3259543; DOI=10.1007/bf00364432;
RA Lock C.B., So A.K., Welsh K.I., Parkes J.D., Trowsdale J.;
RT "MHC class II sequences of an HLA-DR2 narcoleptic.";
RL Immunogenetics 27:449-455(1988).
RN [18]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 24-250 (ALLELE DQA1*03:02/DQA1*03:03) AND
RP NUCLEOTIDE SEQUENCE [MRNA] OF 24-249 (ALLELES DQA1*01:01; DQA1*01:03;
RP DQA1*01:04; DQA1*04:01; DQA1*05:03; DQA1*05:05 AND DQA1*06:01).
RX PubMed=8929711; DOI=10.1111/j.1399-0039.1996.tb02512.x;
RA Yasunaga S., Kimura A., Hamaguchi K., Ronningen K.S., Sasazuki T.;
RT "Different contribution of HLA-DR and -DQ genes in susceptibility and
RT resistance to insulin-dependent diabetes mellitus (IDDM).";
RL Tissue Antigens 47:37-48(1996).
RN [19]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 24-249 (ALLELE DQA1*01:05).
RA Yasunaga S.;
RL Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases.
RN [20]
RP PROTEIN SEQUENCE OF 24-89; 102-120 AND 164-212 (ALLELE DQA1*01:02).
RX PubMed=6576979; DOI=10.1515/bchm2.1983.364.1.749;
RA Goetz H., Kratzin H., Thinnes F.P., Yang C.-Y., Kruse T., Pauly E.,
RA Koelbel S., Egert G., Wernet P., Hilschmann N.;
RT "Primary structure of human class II histocompatibility antigens 3rd
RT communication. Amino acid sequence comparison between DR and DC subclass
RT antigens derived from a lymphoblastoid B cell line homozygous at the HLA
RT loci (HLA-A3,3; B7,7; Dw2,2; DR2,2: MT1,1; Dc1,1: MB1,1).";
RL Hoppe-Seyler's Z. Physiol. Chem. 364:749-755(1983).
RN [21]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 24-209 (ALLELE DQA1*05:01).
RX PubMed=2493052;
RA Kao H.T., Gregersen P.K., Tang J.C., Takahashi T., Wang C.Y., Silver J.;
RT "Molecular analysis of the HLA class II genes in two DRw6-related
RT haplotypes, DRw13 DQw1 and DRw14 DQw3.";
RL J. Immunol. 142:1743-1747(1989).
RN [22]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 29-203 (ALLELES DQA1*04:02 AND
RP DQA1*04:04).
RX PubMed=15853899; DOI=10.1111/j.1399-0039.2005.00389.x;
RA Cordovado S.K., Hancock L.N., Simone A.E., Hendrix M., Mueller P.W.;
RT "High-resolution genotyping of HLA-DQA1 in the GoKinD study and
RT identification of novel alleles HLA-DQA1*040102, HLA-DQA1*0402 and HLA-
RT DQA1*0404.";
RL Tissue Antigens 65:448-458(2005).
RN [23]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 29-203 (ALLELE DQA1*06:02).
RA Simone A.E., Cordovado S.K., Hendrix M.M., Mueller P.W.;
RT "Identification of a novel HLA-DQA1*06 allele detected by sequence-based
RT typing.";
RL Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
RN [24]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 29-203 (ALLELE DQA1*01:07).
RA Hancock L.N., Cordovado S.K., Mueller P.W.;
RT "Identification of a novel HLA-DQA1*01 allele detected by sequence-based
RT typing.";
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [25]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 29-110 (ALLELE DQA1*01:02), AND
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 29-109 (ALLELE DQA1*05:01).
RX PubMed=3372263; DOI=10.1016/0198-8859(88)90034-1;
RA Horn G.T., Bugawan T.L., Long C.M., Manos M.M., Erlich H.A.;
RT "Sequence analysis of HLA class II genes from insulin-dependent diabetic
RT individuals.";
RL Hum. Immunol. 21:249-263(1988).
RN [26]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 29-109 (ALLELE DQA1*05:04).
RA Trejaut J.A., Greville W.D., Dunckley H.;
RT "DQA1 subtyping in Australian Aborigines. Additional evidence for
RT heterogeneity.";
RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN [27]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 31-109 (ALLELE DQA1*01:06).
RX PubMed=10395113; DOI=10.1034/j.1399-0039.1999.530613.x;
RA Luo M., Blanchard J., Maclean I., Brunham R.;
RT "Identification of a novel HLA-DQA1 allele (DQA1*0106) by sequence-based
RT DQA1 typing.";
RL Tissue Antigens 53:595-596(1999).
RN [28]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-74 (ALLELE DQA1*05:02).
RX PubMed=1362295; DOI=10.1111/j.1399-0039.1992.tb02050.x;
RA Marsh S.G., Bodomer J.G.;
RT "HLA class II nucleotide sequences, 1992.";
RL Tissue Antigens 40:229-243(1992).
RN [29]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 36-254 (ALLELE DQA1*05:01).
RX PubMed=3129499;
RA Liu C.P., Bach F.H., Wu S.K.;
RT "Molecular studies of a rare DR2/LD-5a/DQw3 HLA class II haplotype.
RT Multiple genetic mechanisms in the generation of polymorphic HLA class II
RT genes.";
RL J. Immunol. 140:3631-3639(1988).
RN [30]
RP ERRATUM OF PUBMED:3129499.
RA Liu C.P., Bach F.H., Wu S.K.;
RL J. Immunol. 144:15441-15441(1990).
RN [31]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 40-254 (ALLELE DQA1*03:01).
RX PubMed=6815651; DOI=10.1073/pnas.79.20.6337;
RA Auffray C., Korman A.J., Roux-Dosseto M., Bono R., Strominger J.L.;
RT "cDNA clone for the heavy chain of the human B cell alloantigen DC1: strong
RT sequence homology to the HLA-DR heavy chain.";
RL Proc. Natl. Acad. Sci. U.S.A. 79:6337-6341(1982).
RN [32]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-102 (ALLELE DQA1*05:01), AND
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-103 (ALLELE DQA1*01:02).
RX PubMed=2513578; DOI=10.1073/pnas.86.24.9986;
RA Gyllensten U.B., Erlich H.A.;
RT "Ancient roots for polymorphism at the HLA-DQ alpha locus in primates.";
RL Proc. Natl. Acad. Sci. U.S.A. 86:9986-9990(1989).
RN [33]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 119-254 (ALLELE DQA1*01:02).
RX PubMed=2888727; DOI=10.1007/bf00346523;
RA Turco E., Care A., Compagnone-Post P., Robinson C., Cascino I., Trucco M.;
RT "Allelic forms of the alpha- and beta-chain genes encoding DQw1-positive
RT heterodimers.";
RL Immunogenetics 26:282-290(1987).
RN [34]
RP REVIEW.
RX PubMed=8598037; DOI=10.1016/s0092-8674(00)81025-9;
RA Cresswell P.;
RT "Invariant chain structure and MHC class II function.";
RL Cell 84:505-507(1996).
RN [35]
RP REVIEW.
RX PubMed=11684289; DOI=10.1016/s0161-5890(01)00069-4;
RA Villadangos J.A.;
RT "Presentation of antigens by MHC class II molecules: getting the most out
RT of them.";
RL Mol. Immunol. 38:329-346(2001).
RN [36]
RP REVIEW.
RX PubMed=17241953; DOI=10.1016/j.immuni.2007.01.005;
RA Menendez-Benito V., Neefjes J.;
RT "Autophagy in MHC class II presentation: sampling from within.";
RL Immunity 26:1-3(2007).
RN [37]
RP REVIEW.
RX PubMed=18046453; DOI=10.1038/sj.emboj.7601945;
RA Rocha N., Neefjes J.;
RT "MHC class II molecules on the move for successful antigen presentation.";
RL EMBO J. 27:1-5(2008).
RN [38]
RP REVIEW.
RX PubMed=19092054; DOI=10.1242/jcs.035089;
RA Berger A.C., Roche P.A.;
RT "MHC class II transport at a glance.";
RL J. Cell Sci. 122:1-4(2009).
RN [39]
RP REVIEW.
RX PubMed=19533806; DOI=10.3748/wjg.15.2855;
RA Beswick E.J., Reyes V.E.;
RT "CD74 in antigen presentation, inflammation, and cancers of the
RT gastrointestinal tract.";
RL World J. Gastroenterol. 15:2855-2861(2009).
RN [40]
RP X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 27-207 OF HLA-DQA1/HLA-DQB1
RP HETERODIMER IN COMPLEX WITH INS PEPTIDE, SUBUNIT, GLYCOSYLATION AT ASN-103,
RP AND DISULFIDE BOND.
RX PubMed=11376336; DOI=10.1038/88694;
RA Lee K.H., Wucherpfennig K.W., Wiley D.C.;
RT "Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to
RT type 1 diabetes.";
RL Nat. Immunol. 2:501-507(2001).
RN [41]
RP X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 24-219 OF HLA-DQA1/HLA-DQB1
RP HETERODIMER (HLA-DQ0602) IN COMPLEX WITH HCRT PEPTIDE, POLYMORPHISM,
RP SUBUNIT, AND DISULFIDE BOND.
RX PubMed=14769912; DOI=10.1073/pnas.0308458100;
RA Siebold C., Hansen B.E., Wyer J.R., Harlos K., Esnouf R.E., Svejgaard A.,
RA Bell J.I., Strominger J.L., Jones E.Y., Fugger L.;
RT "Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and
RT confers strong susceptibility to narcolepsy.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:1999-2004(2004).
RN [42]
RP X-RAY CRYSTALLOGRAPHY (2.22 ANGSTROMS) OF 24-216 OF HLA-DQA1/HLA-DQB1
RP HETERODIMER (DQ2) IN COMPLEX WITH TRITICUM AESTIVUM ALPHA/BETA-GLIADIN
RP PEPTIDE, SUBUNIT, AND POLYMORPHISM.
RX PubMed=15020763; DOI=10.1073/pnas.0306885101;
RA Kim C.Y., Quarsten H., Bergseng E., Khosla C., Sollid L.M.;
RT "Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in
RT celiac disease.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:4175-4179(2004).
RN [43]
RP X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 24-206 OF HLA-DQA1/HLA-DQB1
RP HETERODIMER IN COMPLEX WITH TRITICUM AESTIVUM ALPHA/BETA-GLIADIN, SUBUNIT,
RP AND DISULFIDE BOND.
RX PubMed=17629515; DOI=10.1016/j.immuni.2007.05.015;
RA Henderson K.N., Tye-Din J.A., Reid H.H., Chen Z., Borg N.A., Beissbarth T.,
RA Tatham A., Mannering S.I., Purcell A.W., Dudek N.L., van Heel D.A.,
RA McCluskey J., Rossjohn J., Anderson R.P.;
RT "A structural and immunological basis for the role of human leukocyte
RT antigen DQ8 in celiac disease.";
RL Immunity 27:23-34(2007).
CC -!- FUNCTION: Binds peptides derived from antigens that access the
CC endocytic route of antigen presenting cells (APC) and presents them on
CC the cell surface for recognition by the CD4 T-cells. The peptide
CC binding cleft accommodates peptides of 10-30 residues. The peptides
CC presented by MHC class II molecules are generated mostly by degradation
CC of proteins that access the endocytic route, where they are processed
CC by lysosomal proteases and other hydrolases. Exogenous antigens that
CC have been endocytosed by the APC are thus readily available for
CC presentation via MHC II molecules, and for this reason this antigen
CC presentation pathway is usually referred to as exogenous. As membrane
CC proteins on their way to degradation in lysosomes as part of their
CC normal turn-over are also contained in the endosomal/lysosomal
CC compartments, exogenous antigens must compete with those derived from
CC endogenous components. Autophagy is also a source of endogenous
CC peptides, autophagosomes constitutively fuse with MHC class II loading
CC compartments. In addition to APCs, other cells of the gastrointestinal
CC tract, such as epithelial cells, express MHC class II molecules and
CC CD74 and act as APCs, which is an unusual trait of the GI tract. To
CC produce a MHC class II molecule that presents an antigen, three MHC
CC class II molecules (heterodimers of an alpha and a beta chain)
CC associate with a CD74 trimer in the ER to form a heterononamer. Soon
CC after the entry of this complex into the endosomal/lysosomal system
CC where antigen processing occurs, CD74 undergoes a sequential
CC degradation by various proteases, including CTSS and CTSL, leaving a
CC small fragment termed CLIP (class-II-associated invariant chain
CC peptide). The removal of CLIP is facilitated by HLA-DM via direct
CC binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM
CC stabilizes MHC class II molecules until primary high affinity antigenic
CC peptides are bound. The MHC II molecule bound to a peptide is then
CC transported to the cell membrane surface. In B-cells, the interaction
CC between HLA-DM and MHC class II molecules is regulated by HLA-DO.
CC Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal
CC microenvironment has been implicated in the regulation of antigen
CC loading into MHC II molecules, increased acidification produces
CC increased proteolysis and efficient peptide loading.
CC -!- SUBUNIT: Heterodimer of an alpha and a beta subunit; also referred as
CC MHC class II molecule. In the endoplasmic reticulum (ER) it forms a
CC heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also
CC known as invariant chain or HLA class II histocompatibility antigen
CC gamma chain). In the endosomal/lysosomal system; CD74 undergoes
CC sequential degradation by various proteases; leaving a small fragment
CC termed CLIP on each MHC class II molecule. MHC class II molecule
CC interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP
CC and facilitate the binding of antigenic peptides.
CC {ECO:0000269|PubMed:11376336, ECO:0000269|PubMed:14769912,
CC ECO:0000269|PubMed:15020763, ECO:0000269|PubMed:17629515}.
CC -!- INTERACTION:
CC P01909; P01920: HLA-DQB1; NbExp=8; IntAct=EBI-713389, EBI-1038012;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
CC protein. Endoplasmic reticulum membrane; Single-pass type I membrane
CC protein. Golgi apparatus, trans-Golgi network membrane; Single-pass
CC type I membrane protein. Endosome membrane; Single-pass type I membrane
CC protein. Lysosome membrane; Single-pass type I membrane protein.
CC Note=The MHC class II complex transits through a number of
CC intracellular compartments in the endocytic pathway until it reaches
CC the cell membrane for antigen presentation.
CC -!- POLYMORPHISM: The following alleles of DQA1 are known: DQA1*01:01,
CC DQA1*01:02, DQA1*01:03, DQA1*01:04, DQA1*01:05, DQA1*01:06, DQA1*01:07,
CC DQA1*02:01, DQA1*03:01, DQA1*03:02, DQA1*03:03, DQA1*04:01, DQA1*04:02,
CC DQA1*04:03, DQA1*04:04, DQA1*05:01, DQA1*05:02, DQA1*05:03, DQA1*05:04,
CC DQA1*05:05, DQA1*05:06, DQA1*05:07, DQA1*05:08, DQA1*05:09, DQA1*06:01,
CC DQA1*06:02. The sequence shown is that of DQA1*05:01.
CC -!- POLYMORPHISM: DQ2 (heterodimer of DQA1*05:01/DQB1*02:01) is associated
CC with more than 90% of celiac disease patients. A minority displays DQ8
CC (heterodimer of DQA1*03/DQB1*03:02). DQ0602 (heterodimer of
CC DQA1*01:02/DQB1*06:02) confers dominant protection against type 1
CC diabetes (T1D) and strong susceptibility to narcolepsy.
CC -!- SIMILARITY: Belongs to the MHC class II family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD56720.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; X00033; CAA24917.1; -; mRNA.
DR EMBL; X00370; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; X00452; CAA25141.1; -; mRNA.
DR EMBL; M16995; AAA59760.1; -; mRNA.
DR EMBL; U92032; AAB91990.1; -; Genomic_DNA.
DR EMBL; AY663395; AAU87978.1; -; Genomic_DNA.
DR EMBL; AY663398; AAU87987.1; -; Genomic_DNA.
DR EMBL; AY663400; AAU87992.1; -; Genomic_DNA.
DR EMBL; AY663406; AAU88007.1; -; Genomic_DNA.
DR EMBL; AY663411; AAU88022.1; -; Genomic_DNA.
DR EMBL; AY663413; AAU88028.1; -; Genomic_DNA.
DR EMBL; DQ178403; ABA86855.1; -; Genomic_DNA.
DR EMBL; DQ178400; ABA86855.1; JOINED; Genomic_DNA.
DR EMBL; DQ178401; ABA86855.1; JOINED; Genomic_DNA.
DR EMBL; DQ178402; ABA86855.1; JOINED; Genomic_DNA.
DR EMBL; DQ178407; ABA86856.1; -; Genomic_DNA.
DR EMBL; DQ178404; ABA86856.1; JOINED; Genomic_DNA.
DR EMBL; DQ178405; ABA86856.1; JOINED; Genomic_DNA.
DR EMBL; DQ178406; ABA86856.1; JOINED; Genomic_DNA.
DR EMBL; DQ178411; ABA86857.1; -; Genomic_DNA.
DR EMBL; DQ178408; ABA86857.1; JOINED; Genomic_DNA.
DR EMBL; DQ178409; ABA86857.1; JOINED; Genomic_DNA.
DR EMBL; DQ178410; ABA86857.1; JOINED; Genomic_DNA.
DR EMBL; DQ178415; ABA86858.1; -; Genomic_DNA.
DR EMBL; DQ178412; ABA86858.1; JOINED; Genomic_DNA.
DR EMBL; DQ178413; ABA86858.1; JOINED; Genomic_DNA.
DR EMBL; DQ178414; ABA86858.1; JOINED; Genomic_DNA.
DR EMBL; M29616; AAA59759.1; -; Genomic_DNA.
DR EMBL; M29613; AAA59759.1; JOINED; Genomic_DNA.
DR EMBL; AF322870; AAK11577.1; -; Genomic_DNA.
DR EMBL; AF322867; AAK11577.1; JOINED; Genomic_DNA.
DR EMBL; AF322868; AAK11577.1; JOINED; Genomic_DNA.
DR EMBL; AF322869; AAK11577.1; JOINED; Genomic_DNA.
DR EMBL; AF395700; AAM69677.1; -; Genomic_DNA.
DR EMBL; AF395697; AAM69677.1; JOINED; Genomic_DNA.
DR EMBL; AF395698; AAM69677.1; JOINED; Genomic_DNA.
DR EMBL; AF395699; AAM69677.1; JOINED; Genomic_DNA.
DR EMBL; CR450297; CAG29293.1; -; mRNA.
DR EMBL; AM042559; CAJ14960.1; -; Genomic_DNA.
DR EMBL; AM042560; CAJ14961.1; -; Genomic_DNA.
DR EMBL; AK313975; BAG36689.1; -; mRNA.
DR EMBL; BX248406; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL662789; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; Z84489; CAB06491.1; -; Genomic_DNA.
DR EMBL; BC008585; AAH08585.1; -; mRNA.
DR EMBL; BC157865; AAI57866.1; -; mRNA.
DR EMBL; L46875; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; L46876; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; L46877; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; L46878; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; L46880; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; L46881; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; M11124; AAA59754.1; -; mRNA.
DR EMBL; M20431; AAA59758.1; -; mRNA.
DR EMBL; L34082; AAC41950.1; -; mRNA.
DR EMBL; L34085; AAC41953.1; -; mRNA.
DR EMBL; L34086; AAC41954.1; -; mRNA.
DR EMBL; L34089; AAC41957.1; -; mRNA.
DR EMBL; L34090; AAC41958.1; -; mRNA.
DR EMBL; L34092; AAC41960.1; -; mRNA.
DR EMBL; L34093; AAC41961.1; -; mRNA.
DR EMBL; L34094; AAC41962.1; -; mRNA.
DR EMBL; L42625; AAA85334.1; -; mRNA.
DR EMBL; AY197775; AAO45622.1; -; Genomic_DNA.
DR EMBL; AY547314; AAS49496.1; -; Genomic_DNA.
DR EMBL; AY206406; AAO47362.1; -; Genomic_DNA.
DR EMBL; AY585236; AAT09985.1; -; Genomic_DNA.
DR EMBL; M34997; AAA35772.1; -; Genomic_DNA.
DR EMBL; M34999; AAA74633.1; -; Genomic_DNA.
DR EMBL; U85035; AAB41891.1; -; Genomic_DNA.
DR EMBL; AF109734; AAD56720.1; ALT_SEQ; Genomic_DNA.
DR EMBL; U03675; AAB60341.1; -; Genomic_DNA.
DR EMBL; M20506; AAA59774.1; -; mRNA.
DR EMBL; J00199; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; M17846; AAA59707.1; -; mRNA.
DR PIR; A02211; HLHUD1.
DR PIR; A02213; HLHUDQ.
DR PIR; A02214; HLHUD7.
DR PIR; A02215; HLHU3C.
DR PIR; A93326; HLHUDC.
DR PIR; B27628; B27628.
DR PIR; D34512; D34512.
DR RefSeq; NP_002113.2; NM_002122.3.
DR PDB; 1JK8; X-ray; 2.40 A; A=27-206.
DR PDB; 1S9V; X-ray; 2.22 A; A/D=24-216.
DR PDB; 1UVQ; X-ray; 1.80 A; A=24-218.
DR PDB; 2NNA; X-ray; 2.10 A; A=24-206.
DR PDB; 4GG6; X-ray; 3.20 A; A/C=24-206.
DR PDB; 4OZF; X-ray; 2.70 A; A=24-206.
DR PDB; 4OZG; X-ray; 3.00 A; A/C=24-206.
DR PDB; 4OZH; X-ray; 2.80 A; A/C=24-206.
DR PDB; 4OZI; X-ray; 3.20 A; A/C=24-206.
DR PDB; 5KSA; X-ray; 2.00 A; A=24-206.
DR PDB; 5KSB; X-ray; 2.90 A; A/C=24-206.
DR PDB; 5KSU; X-ray; 2.73 A; A/D=24-216.
DR PDB; 5KSV; X-ray; 2.19 A; A=24-216.
DR PDB; 6MFF; X-ray; 2.60 A; A=24-206.
DR PDB; 6MFG; X-ray; 2.00 A; A/C=24-206.
DR PDB; 6U3M; X-ray; 1.90 A; A/C=24-206.
DR PDB; 6U3N; X-ray; 2.80 A; A=24-206.
DR PDB; 7SG0; X-ray; 3.00 A; A=24-206.
DR PDB; 7SG1; X-ray; 3.10 A; A/F=24-206.
DR PDB; 7SG2; X-ray; 3.10 A; A/F=24-206.
DR PDBsum; 1JK8; -.
DR PDBsum; 1S9V; -.
DR PDBsum; 1UVQ; -.
DR PDBsum; 2NNA; -.
DR PDBsum; 4GG6; -.
DR PDBsum; 4OZF; -.
DR PDBsum; 4OZG; -.
DR PDBsum; 4OZH; -.
DR PDBsum; 4OZI; -.
DR PDBsum; 5KSA; -.
DR PDBsum; 5KSB; -.
DR PDBsum; 5KSU; -.
DR PDBsum; 5KSV; -.
DR PDBsum; 6MFF; -.
DR PDBsum; 6MFG; -.
DR PDBsum; 6U3M; -.
DR PDBsum; 6U3N; -.
DR PDBsum; 7SG0; -.
DR PDBsum; 7SG1; -.
DR PDBsum; 7SG2; -.
DR AlphaFoldDB; P01909; -.
DR SMR; P01909; -.
DR BioGRID; 109362; 154.
DR BioGRID; 1529240; 5.
DR IntAct; P01909; 12.
DR MINT; P01909; -.
DR ChEMBL; CHEMBL4105884; -.
DR TCDB; 9.A.75.1.1; the mhc ii receptor (mhc2r) family.
DR GlyConnect; 1986; 2 N-Linked glycans (1 site).
DR GlyGen; P01909; 4 sites, 2 N-linked glycans (1 site).
DR BioMuta; HLA-DQA1; -.
DR DMDM; 122188; -.
DR jPOST; P01909; -.
DR MassIVE; P01909; -.
DR PeptideAtlas; P01909; -.
DR PRIDE; P01909; -.
DR ProteomicsDB; 51510; -.
DR Antibodypedia; 2728; 690 antibodies from 38 providers.
DR CPTC; P01909; 2 antibodies.
DR DNASU; 3117; -.
DR Ensembl; ENST00000343139.11; ENSP00000339398.5; ENSG00000196735.13.
DR Ensembl; ENST00000374949.2; ENSP00000364087.2; ENSG00000196735.13.
DR Ensembl; ENST00000383251.6; ENSP00000372738.2; ENSG00000206305.12.
DR Ensembl; ENST00000395363.5; ENSP00000378767.1; ENSG00000196735.13.
DR Ensembl; ENST00000399675.5; ENSP00000382583.1; ENSG00000206305.12.
DR Ensembl; ENST00000399678.5; ENSP00000382586.1; ENSG00000206305.12.
DR Ensembl; ENST00000418023.5; ENSP00000387892.1; ENSG00000232062.9.
DR Ensembl; ENST00000444296.6; ENSP00000413237.2; ENSG00000232062.9.
DR GeneID; 3117; -.
DR KEGG; hsa:3117; -.
DR UCSC; uc003obr.4; human.
DR CTD; 3117; -.
DR DisGeNET; 3117; -.
DR GeneCards; HLA-DQA1; -.
DR GeneReviews; HLA-DQA1; -.
DR HGNC; HGNC:4942; HLA-DQA1.
DR HPA; ENSG00000196735; Tissue enhanced (lung, lymphoid tissue).
DR MalaCards; HLA-DQA1; -.
DR MIM; 146880; gene.
DR neXtProt; NX_P01909; -.
DR NIAGADS; ENSG00000196735; -.
DR Orphanet; 391490; Adult-onset myasthenia gravis.
DR Orphanet; 930; Idiopathic achalasia.
DR Orphanet; 555; NON RARE IN EUROPE: Celiac disease.
DR Orphanet; 243377; NON RARE IN EUROPE: Diabetes mellitus type 1.
DR PharmGKB; PA35066; -.
DR VEuPathDB; HostDB:ENSG00000196735; -.
DR HOGENOM; CLU_069380_0_0_1; -.
DR InParanoid; P01909; -.
DR OrthoDB; 1132781at2759; -.
DR PhylomeDB; P01909; -.
DR TreeFam; TF333797; -.
DR PathwayCommons; P01909; -.
DR Reactome; R-HSA-202424; Downstream TCR signaling.
DR Reactome; R-HSA-202427; Phosphorylation of CD3 and TCR zeta chains.
DR Reactome; R-HSA-202430; Translocation of ZAP-70 to Immunological synapse.
DR Reactome; R-HSA-202433; Generation of second messenger molecules.
DR Reactome; R-HSA-2132295; MHC class II antigen presentation.
DR Reactome; R-HSA-389948; PD-1 signaling.
DR Reactome; R-HSA-877300; Interferon gamma signaling.
DR SignaLink; P01909; -.
DR SIGNOR; P01909; -.
DR BioGRID-ORCS; 3117; 7 hits in 1014 CRISPR screens.
DR ChiTaRS; HLA-DQA1; human.
DR EvolutionaryTrace; P01909; -.
DR GenomeRNAi; 3117; -.
DR Pharos; P01909; Tbio.
DR PRO; PR:P01909; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; P01909; protein.
DR Bgee; ENSG00000196735; Expressed in gall bladder and 160 other tissues.
DR ExpressionAtlas; P01909; baseline and differential.
DR Genevisible; P01909; HS.
DR GO; GO:0030669; C:clathrin-coated endocytic vesicle membrane; TAS:Reactome.
DR GO; GO:0030666; C:endocytic vesicle membrane; TAS:Reactome.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome.
DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome.
DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome.
DR GO; GO:0005887; C:integral component of plasma membrane; NAS:UniProtKB.
DR GO; GO:0005765; C:lysosomal membrane; TAS:Reactome.
DR GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR GO; GO:0042613; C:MHC class II protein complex; ISS:CAFA.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0032588; C:trans-Golgi network membrane; TAS:Reactome.
DR GO; GO:0030658; C:transport vesicle membrane; TAS:Reactome.
DR GO; GO:0023026; F:MHC class II protein complex binding; IBA:GO_Central.
DR GO; GO:0032395; F:MHC class II receptor activity; TAS:UniProtKB.
DR GO; GO:0042605; F:peptide antigen binding; ISS:CAFA.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IBA:GO_Central.
DR GO; GO:0006955; P:immune response; NAS:UniProtKB.
DR GO; GO:0002503; P:peptide antigen assembly with MHC class II protein complex; IBA:GO_Central.
DR GO; GO:0050870; P:positive regulation of T cell activation; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 3.10.320.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR014745; MHC_II_a/b_N.
DR InterPro; IPR001003; MHC_II_a_N.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00993; MHC_II_alpha; 1.
DR SMART; SM00407; IGc1; 1.
DR SMART; SM00920; MHC_II_alpha; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR SUPFAM; SSF54452; SSF54452; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Adaptive immunity; Cell membrane; Direct protein sequencing;
KW Disulfide bond; Endoplasmic reticulum; Endosome; Glycoprotein;
KW Golgi apparatus; Immunity; Lysosome; Membrane; MHC II; Reference proteome;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000269|PubMed:6576979"
FT CHAIN 24..254
FT /note="HLA class II histocompatibility antigen, DQ alpha 1
FT chain"
FT /id="PRO_0000018970"
FT TOPO_DOM 24..216
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..239
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 240..254
FT /note="Cytoplasmic"
FT DOMAIN 112..204
FT /note="Ig-like C1-type"
FT REGION 24..119
FT /note="Alpha-1"
FT REGION 120..203
FT /note="Alpha-2"
FT REGION 204..216
FT /note="Connecting peptide"
FT CARBOHYD 103
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 143
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 132..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114,
FT ECO:0000269|PubMed:11376336, ECO:0000269|PubMed:14769912,
FT ECO:0000269|PubMed:17629515"
FT VARIANT 8
FT /note="M -> L (in allele DQA1*01:01, allele DQA1*01:02,
FT allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05,
FT allele DQA1*04:01 and allele DQA1*06:01; dbSNP:rs1047989)"
FT /id="VAR_033399"
FT VARIANT 11
FT /note="A -> T (in allele DQA1*05:05, allele DQA1*05:08 and
FT allele DQA1*05:09; dbSNP:rs1047992)"
FT /id="VAR_033400"
FT VARIANT 17
FT /note="V -> M (in allele DQA1*01:04 and allele DQA1*01:05;
FT dbSNP:rs12722039)"
FT /id="VAR_050380"
FT VARIANT 18
FT /note="M -> T (in allele DQA1*03:03; dbSNP:rs11545686)"
FT /id="VAR_050381"
FT VARIANT 24
FT /note="E -> K (in allele DQA1*05:09; dbSNP:rs41545012)"
FT /id="VAR_060493"
FT VARIANT 25
FT /note="D -> G (in allele DQA1*01:04 and allele DQA1*01:05;
FT dbSNP:rs12722042)"
FT /id="VAR_050382"
FT VARIANT 34
FT /note="Y -> C (in allele DQA1*01:01, allele DQA1*01:02,
FT allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05,
FT allele DQA1*01:06 and allele DQA1*01:07; dbSNP:rs1129740)"
FT /id="VAR_060494"
FT VARIANT 41
FT /note="S -> F (in allele DQA1*01:01, allele DQA1*01:02,
FT allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05,
FT allele DQA1*01:06 and allele DQA1*01:07; dbSNP:rs1071630)"
FT /id="VAR_033401"
FT VARIANT 44
FT /note="P -> L (in allele DQA1*05:04; dbSNP:rs41549715)"
FT /id="VAR_060495"
FT VARIANT 48
FT /note="Y -> F (in allele DQA1*02:01, allele DQA1*01:03,
FT allele DQA1*06:01 and allele DQA1*06:02; dbSNP:rs12722051)"
FT /id="VAR_033402"
FT VARIANT 49
FT /note="T -> S (in allele DQA1*03:01, allele DQA1*03:02 and
FT allele DQA1*03:03; dbSNP:rs1048023)"
FT /id="VAR_033403"
FT VARIANT 57
FT /note="Q -> E (in allele DQA1*01:01, allele DQA1*01:04,
FT allele DQA1*01:05, allele DQA1*01:07, allele DQA1*02:01,
FT allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03;
FT dbSNP:rs10093)"
FT /id="VAR_014604"
FT VARIANT 63
FT /note="G -> E (in allele DQA1*01:01, allele DQA1*01:02,
FT allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05,
FT allele DQA1*01:06, allele DQA1*01:07, allele DQA1*02:01,
FT allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03;
FT dbSNP:rs1142323)"
FT /id="VAR_060496"
FT VARIANT 64
FT /note="R -> K (in allele DQA1*01:03; dbSNP:rs36219699)"
FT /id="VAR_050383"
FT VARIANT 67
FT /note="T -> A (in allele DQA1*01:06; dbSNP:rs41543221)"
FT /id="VAR_060497"
FT VARIANT 68
FT /note="V -> A (in allele DQA1*01:01, allele DQA1*01:02,
FT allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05,
FT allele DQA1*01:06 and allele DQA1*01:07; dbSNP:rs1142324)"
FT /id="VAR_060498"
FT VARIANT 70
FT /note="C -> K (in allele DQA1*02:01; requires 2 nucleotide
FT substitutions)"
FT /id="VAR_060499"
FT VARIANT 70
FT /note="C -> Q (in allele DQA1*03:01, allele DQA1*03:02 and
FT allele DQA1*03:03; requires 2 nucleotide substitutions)"
FT /id="VAR_060500"
FT VARIANT 70
FT /note="C -> R (in allele DQA1*01:01, allele DQA1*01:02,
FT allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05,
FT allele DQA1*01:06 and allele DQA1*01:07; dbSNP:rs1142326)"
FT /id="VAR_060501"
FT VARIANT 70
FT /note="C -> Y (in dbSNP:rs3207983)"
FT /id="VAR_033404"
FT VARIANT 71
FT /note="L -> W (in allele DQA1*01:01, allele
FT DQA1*01:02,allele DQA1*01:03, allele DQA1*01:04, allele
FT DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07;
FT dbSNP:rs1142328)"
FT /id="VAR_060502"
FT VARIANT 73
FT /note="V -> D (in dbSNP:rs760671632)"
FT /id="VAR_033406"
FT VARIANT 73
FT /note="V -> E (in allele DQA1*01:01, allele DQA1*01:02,
FT allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05,
FT allele DQA1*01:06 and allele DQA1*01:07; dbSNP:rs3208105)"
FT /id="VAR_060503"
FT VARIANT 73
FT /note="V -> L (in allele DQA1*02:01, allele DQA1*03:01,
FT allele DQA1*03:02 and allele DQA1*03:03; dbSNP:rs12722061)"
FT /id="VAR_033405"
FT VARIANT 74
FT /note="L -> F (in allele DQA1*01:01, allele DQA1*01:02,
FT allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05,
FT allele DQA1*01:06, allele DQA1*01:07, allele DQA1*02:01,
FT allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03;
FT dbSNP:rs9272698)"
FT /id="VAR_060504"
FT VARIANT 75
FT /note="R -> H (in allele DQA1*02:01; dbSNP:rs28383449)"
FT /id="VAR_060505"
FT VARIANT 75
FT /note="R -> S (in allele DQA1*01:01, allele DQA1*01:02,
FT allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05,
FT allele DQA1*01:06 and allele DQA1*01:07; dbSNP:rs9272699)"
FT /id="VAR_060506"
FT VARIANT 76
FT /note="Q -> K (in allele DQA1*01:01, allele DQA1*01:02,
FT allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05,
FT allele DQA1*01:06 and allele DQA1*01:07; dbSNP:rs1048052)"
FT /id="VAR_060507"
FT VARIANT 76
FT /note="Q -> R (in allele DQA1*02:01, allele DQA1*03:01,
FT allele DQA1*03:02 and allele DQA1*03:03; dbSNP:rs12722069)"
FT /id="VAR_060508"
FT VARIANT 77
FT /note="F -> L (in allele DQA1*02:01; dbSNP:rs3188043)"
FT /id="VAR_060509"
FT VARIANT 78
FT /note="R -> GG (in allele DQA1*01:01, allele DQA1*01:02,
FT allele DQA1*01:03, allele DQA1*01:04, allele
FT DQA1*01:05,allele DQA1*01:06 and allele DQA1*01:07;
FT dbSNP:rs4193)"
FT /id="VAR_060510"
FT VARIANT 78
FT /note="R -> RR (in allele DQA1*03:01, allele DQA1*03:02 and
FT allele DQA1*03:03)"
FT /id="VAR_060511"
FT VARIANT 81
FT /note="P -> R (in allele DQA1*05:02; dbSNP:rs41541412)"
FT /id="VAR_060512"
FT VARIANT 83
FT /note="F -> G (in allele DQA1*01:01, allele DQA1*01:02,
FT allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05,
FT allele DQA1*01:06 and allele DQA1*01:07; requires 2
FT nucleotide substitutions)"
FT /id="VAR_060513"
FT VARIANT 86
FT /note="T -> R (in allele DQA1*01:01, allele DQA1*01:02,
FT allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05,
FT allele DQA1*01:06 and allele DQA1*01:07; dbSNP:rs1142333)"
FT /id="VAR_033408"
FT VARIANT 88
FT /note="I -> M (in allele DQA1*01:01, allele DQA1*01:02,
FT allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05,
FT allele DQA1*01:06 and allele DQA1*01:07; dbSNP:rs1142334)"
FT /id="VAR_033409"
FT VARIANT 91
FT /note="L -> A (in allele DQA1*01:01, allele DQA1*01:02,
FT allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05,
FT allele DQA1*01:06 and allele DQA1*01:07; requires 2
FT nucleotide substitutions)"
FT /id="VAR_060514"
FT VARIANT 91
FT /note="L -> T (in allele DQA1*04:01, allele DQA1*04:02,
FT allele DQA1*04:04, allele DQA1*06:01 and allele DQA1*06:02;
FT requires 2 nucleotide substitutions)"
FT /id="VAR_060515"
FT VARIANT 97
FT /note="S -> I (in allele DQA1*01:01, allele DQA1*01:02,
FT allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05,
FT allele DQA1*01:06, allele DQA1*01:07, allele DQA1*02:01,
FT allele DQA1*03:01, allele DQA1*03:02, allele DQA1*03:03,
FT allele DQA1*04:01, allele DQA1*04:02, allele DQA1*04:04,
FT allele DQA1*06:01 and allele DQA1*06:02; dbSNP:rs9279910)"
FT /id="VAR_060516"
FT VARIANT 98
FT /note="L -> M (in allele DQA1*01:01, allele DQA1*01:02,
FT allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05,
FT allele DQA1*01:06 and allele DQA1*01:07; dbSNP:rs1064944)"
FT /id="VAR_060517"
FT VARIANT 98
FT /note="L -> V (in allele DQA1*03:01, allele DQA1*03:02 and
FT allele DQA1*03:03; dbSNP:rs1064944)"
FT /id="VAR_060518"
FT VARIANT 101
FT /note="R -> C (in allele DQA1*01:07; dbSNP:rs41542116)"
FT /id="VAR_060519"
FT VARIANT 102
FT /note="S -> Y (in allele DQA1*01:01, allele DQA1*01:02,
FT allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05,
FT allele DQA1*01:06 and allele DQA1*01:07; dbSNP:rs1129808)"
FT /id="VAR_050384"
FT VARIANT 124
FT /note="L -> V (in allele DQA1*05:06; dbSNP:rs41555012)"
FT /id="VAR_060520"
FT VARIANT 129
FT /note="I -> T (in allele DQA1*01:01, allele DQA1*01:02,
FT allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05,
FT allele DQA1*01:07, allele DQA1*02:01, allele DQA1*03:01,
FT allele DQA1*03:02, allele DQA1*03:03, allele DQA1*04:01,
FT allele DQA1*04:02, allele DQA1*04:04, allele DQA1*06:01 and
FT allele DQA1*06:02; dbSNP:rs707952)"
FT /id="VAR_050385"
FT VARIANT 151
FT /note="H -> Q (in allele DQA1*01:01, allele DQA1*01:02,
FT allele DQA1*01:04, allele DQA1*01:05 and allele DQA1*01:07;
FT dbSNP:rs707950)"
FT /id="VAR_050386"
FT VARIANT 152
FT /note="S -> A (in allele DQA1*01:03; dbSNP:rs41547417)"
FT /id="VAR_060521"
FT VARIANT 160
FT /note="T -> I (in allele DQA1*04:02; dbSNP:rs41545514)"
FT /id="VAR_060522"
FT VARIANT 161
FT /note="S -> I (in allele DQA1*05:08; dbSNP:rs41544114)"
FT /id="VAR_060524"
FT VARIANT 161
FT /note="S -> R (in allele DQA1*06:02; dbSNP:rs41552014)"
FT /id="VAR_060523"
FT VARIANT 175
FT /note="Y -> H (in allele DQA1*04:04; dbSNP:rs41550317)"
FT /id="VAR_060525"
FT VARIANT 178
FT /note="L -> F (in allele DQA1*01:01, allele DQA1*01:02,
FT allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05,
FT allele DQA1*01:07, allele DQA1*02:01, allele DQA1*03:01,
FT allele DQA1*03:02, allele DQA1*03:03, allele DQA1*04:01,
FT allele DQA1*04:02, allele DQA1*04:04, allele DQA1*06:01 and
FT allele DQA1*06:02; dbSNP:rs707949)"
FT /id="VAR_060526"
FT VARIANT 182
FT /note="A -> D (in allele DQA1*03:02 and allele DQA1*03:03;
FT dbSNP:rs7990)"
FT /id="VAR_060527"
FT VARIANT 182
FT /note="A -> S (in allele DQA1*05:03, allele DQA1*05:06 and
FT allele DQA1*05:07; dbSNP:rs41561312)"
FT /id="VAR_060528"
FT VARIANT 183
FT /note="E -> D (in allele DQA1*01:01, allele DQA1*01:02,
FT allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05,
FT allele DQA1*01:07, allele DQA1*02:01, allele DQA1*03:01,
FT allele DQA1*03:02, allele DQA1*03:03, allele DQA1*04:01,
FT allele DQA1*04:02, allele DQA1*04:04, allele DQA1*06:01 and
FT allele DQA1*06:02; dbSNP:rs707963)"
FT /id="VAR_060529"
FT VARIANT 185
FT /note="S -> I (in allele DQA1*01:01, allele DQA1*01:02,
FT allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05,
FT allele DQA1*01:07, allele DQA1*02:01, allele DQA1*03:01,
FT allele DQA1*03:02, allele DQA1*03:03, allele DQA1*04:01,
FT allele DQA1*04:02, allele DQA1*04:04, allele DQA1*06:01 and
FT allele DQA1*06:02; dbSNP:rs707962)"
FT /id="VAR_060530"
FT VARIANT 197
FT /note="K -> E (in allele DQA1*02:01, allele DQA1*03:01,
FT allele DQA1*03:02, allele DQA1*03:03, allele DQA1*04:01,
FT allele DQA1*04:02, allele DQA1*04:04, allele DQA1*06:01 and
FT allele DQA1*06:02; dbSNP:rs2308891)"
FT /id="VAR_060531"
FT VARIANT 197
FT /note="K -> Q (in allele DQA1*01:01, allele DQA1*01:02,
FT allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05 and
FT allele DQA1*01:07; dbSNP:rs2308891)"
FT /id="VAR_060532"
FT VARIANT 209
FT /note="A -> T (in allele DQA1*03:01, allele DQA1*03:02 and
FT allele DQA1*03:03; dbSNP:rs9272785)"
FT /id="VAR_050387"
FT VARIANT 221
FT /note="A -> T (in allele DQA1*01:04; dbSNP:rs35087390)"
FT /id="VAR_050388"
FT VARIANT 229
FT /note="V -> M (in allele DQA1*01:02; dbSNP:rs9260)"
FT /id="VAR_033411"
FT VARIANT 230
FT /note="G -> C (in allele DQA1*05:07; dbSNP:rs41545416)"
FT /id="VAR_060533"
FT VARIANT 237
FT /note="F -> L (in allele DQA1*02:01, allele DQA1*03:01,
FT allele DQA1*03:02 and allele DQA1*03:03; dbSNP:rs1048430)"
FT /id="VAR_033412"
FT VARIANT 240
FT /note="R -> Q (in allele DQA1*01:01, allele DQA1*01:02,
FT allele DQA1*01:03, allele DQA1*01:04 and allele DQA1*01:05;
FT dbSNP:rs1048439)"
FT /id="VAR_033413"
FT CONFLICT 11
FT /note="A -> S (in Ref. 4; AAA59760)"
FT /evidence="ECO:0000305"
FT CONFLICT 23..27
FT /note="Missing (in Ref. 16; AAA59754)"
FT /evidence="ECO:0000305"
FT CONFLICT 91
FT /note="L -> H (in Ref. 4; AAA59760)"
FT /evidence="ECO:0000305"
FT CONFLICT 107
FT /note="A -> P (in Ref. 16; AAA59754)"
FT /evidence="ECO:0000305"
FT CONFLICT 156
FT /note="G -> D (in Ref. 3; CAA25141)"
FT /evidence="ECO:0000305"
FT CONFLICT 213
FT /note="E -> D (in Ref. 16; AAA59754)"
FT /evidence="ECO:0000305"
FT STRAND 29..40
FT /evidence="ECO:0007829|PDB:6U3M"
FT TURN 41..44
FT /evidence="ECO:0007829|PDB:6U3M"
FT STRAND 45..52
FT /evidence="ECO:0007829|PDB:6U3M"
FT STRAND 55..61
FT /evidence="ECO:0007829|PDB:6U3M"
FT TURN 62..65
FT /evidence="ECO:0007829|PDB:6U3M"
FT STRAND 66..71
FT /evidence="ECO:0007829|PDB:6U3M"
FT HELIX 72..76
FT /evidence="ECO:0007829|PDB:6U3M"
FT HELIX 81..101
FT /evidence="ECO:0007829|PDB:6U3M"
FT TURN 102..104
FT /evidence="ECO:0007829|PDB:1JK8"
FT STRAND 113..120
FT /evidence="ECO:0007829|PDB:6U3M"
FT STRAND 124..126
FT /evidence="ECO:0007829|PDB:4OZF"
FT STRAND 128..137
FT /evidence="ECO:0007829|PDB:6U3M"
FT STRAND 143..148
FT /evidence="ECO:0007829|PDB:6U3M"
FT STRAND 151..153
FT /evidence="ECO:0007829|PDB:6U3M"
FT STRAND 157..159
FT /evidence="ECO:0007829|PDB:6U3M"
FT STRAND 170..178
FT /evidence="ECO:0007829|PDB:6U3M"
FT STRAND 186..191
FT /evidence="ECO:0007829|PDB:6U3M"
FT STRAND 195..197
FT /evidence="ECO:0007829|PDB:6U3M"
FT STRAND 199..203
FT /evidence="ECO:0007829|PDB:6U3M"
SQ SEQUENCE 254 AA; 27805 MW; 84E12B5A80E2A028 CRC64;
MILNKALMLG ALALTTVMSP CGGEDIVADH VASYGVNLYQ SYGPSGQYTH EFDGDEQFYV
DLGRKETVWC LPVLRQFRFD PQFALTNIAV LKHNLNSLIK RSNSTAATNE VPEVTVFSKS
PVTLGQPNIL ICLVDNIFPP VVNITWLSNG HSVTEGVSET SFLSKSDHSF FKISYLTLLP
SAEESYDCKV EHWGLDKPLL KHWEPEIPAP MSELTETVVC ALGLSVGLVG IVVGTVFIIR
GLRSVGASRH QGPL
