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DQB1_HUMAN
ID   DQB1_HUMAN              Reviewed;         261 AA.
AC   P01920; A1KR27; A2RPH3; A4Q9R4; A4USG2; A4USG5; A6N8I7; A9YQA0; B0S7Y7;
AC   B1A0K6; B1GXI3; B3VLT3; B5BLN7; B7VU69; C0MQ34; C0MQ35; C8ZL52; C8ZLJ8;
AC   C8ZLJ9; C9DRQ3; O19708; O19713; O19724; O62861; O78046; O78221; O78223;
AC   O98034; O98201; P01917; P01918; P01919; P03992; P05537; P79482; P79526;
AC   P79544; P79551; Q08GC8; Q09035; Q0E4V9; Q1M312; Q29731; Q29877; Q29884;
AC   Q29915; Q29966; Q2P9N3; Q2QK85; Q30061; Q30075; Q30076; Q30080; Q30081;
AC   Q30082; Q30083; Q30084; Q30089; Q30095; Q31633; Q38I47; Q45UE3; Q4QZB5;
AC   Q53I44; Q564J6; Q5G841; Q5ISH1; Q5ISH3; Q5W1E1; Q5Y7G8; Q643R4; Q6B9X1;
AC   Q70VH8; Q7YP69; Q8HWH0; Q8MH58; Q8SNB4; Q8SND1; Q8SP70; Q8WMA3; Q9BD17;
AC   Q9MYH2; Q9TPA9; Q9XRY6; Q9XRY7; Q9XRZ2;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   02-MAR-2010, sequence version 2.
DT   03-AUG-2022, entry version 198.
DE   RecName: Full=HLA class II histocompatibility antigen, DQ beta 1 chain;
DE   AltName: Full=MHC class II antigen DQB1;
DE   Flags: Precursor;
GN   Name=HLA-DQB1; Synonyms=HLA-DQB;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*02:01), AND NUCLEOTIDE SEQUENCE
RP   [MRNA] OF 33-261 (CLONE PII-BETA-2) (ALLELE DQB1*05:01).
RX   PubMed=6415003; DOI=10.1016/0198-8859(83)90087-3;
RA   Larhammar D., Andersson G., Andersson M., Bill P., Boehme J., Claesson L.,
RA   Denaro M., Emmoth E., Gustafsson K., Hammarling U., Heldin E.,
RA   Hyldig-Nielsen J.-J., Lind P., Schenning L., Servenius B., Widmark E.,
RA   Rask L., Peterson P.A.;
RT   "Molecular analysis of human class II transplantation antigens and their
RT   genes.";
RL   Hum. Immunol. 8:95-103(1983).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*02:01).
RX   PubMed=6954511; DOI=10.1073/pnas.79.12.3687;
RA   Larhammar D., Schenning L., Gustafsson K., Wiman K., Claesson L., Rask L.,
RA   Peterson P.A.;
RT   "Complete amino acid sequence of an HLA-DR antigen-like beta chain as
RT   predicted from the nucleotide sequence: similarities with immunoglobulins
RT   and HLA-A, -B, and -C antigens.";
RL   Proc. Natl. Acad. Sci. U.S.A. 79:3687-3691(1982).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DQB1*03:02).
RX   PubMed=6316358; DOI=10.1073/pnas.80.23.7313;
RA   Larhammar D., Hyldig-Nielsen J.-J., Servenius B., Andersson G., Rask L.,
RA   Peterson P.A.;
RT   "Exon-intron organization and complete nucleotide sequence of a human major
RT   histocompatibility antigen DC beta gene.";
RL   Proc. Natl. Acad. Sci. U.S.A. 80:7313-7317(1983).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DQB1*02:01).
RX   PubMed=6206493; DOI=10.1073/pnas.81.16.5199;
RA   Boss J.M., Strominger J.L.;
RT   "Cloning and sequence analysis of the human major histocompatibility
RT   complex gene DC-3 beta.";
RL   Proc. Natl. Acad. Sci. U.S.A. 81:5199-5203(1984).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*05:01).
RX   PubMed=2998758; DOI=10.1002/j.1460-2075.1985.tb04012.x;
RA   Tonnelle C., Demars R., Long E.O.;
RT   "DO beta: a new beta chain gene in HLA-D with a distinct regulation of
RT   expression.";
RL   EMBO J. 4:2839-2847(1985).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*05:01).
RX   PubMed=2888727; DOI=10.1007/bf00346523;
RA   Turco E., Care A., Compagnone-Post P., Robinson C., Cascino I., Trucco M.;
RT   "Allelic forms of the alpha- and beta-chain genes encoding DQw1-positive
RT   heterodimers.";
RL   Immunogenetics 26:282-290(1987).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DQB1*03:02).
RX   PubMed=3036828; DOI=10.1016/s0021-9258(18)47482-0;
RA   Jonsson A.-K., Hyldig-Nielsen J.-J., Servenius B., Larhammar D.,
RA   Andersson G., Joergensen F., Peterson P.A., Rask L.;
RT   "Class II genes of the human major histocompatibility complex. Comparisons
RT   of the DQ and DX alpha and beta genes.";
RL   J. Biol. Chem. 262:8767-8777(1987).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS VAL-15; SER-28; GLY-45; LEU-58;
RP   GLY-77; GLY-102 AND ARG-199.
RX   PubMed=3584986;
RA   Schiffenbauer J., Didier D.K., Klearman M., Rice K., Shuman S.,
RA   Tieber V.L., Kittlesen D.J., Schwartz B.D.;
RT   "Complete sequence of the HLA DQ alpha and DQ beta cDNA from a DR5/DQw3
RT   cell line.";
RL   J. Immunol. 139:228-233(1987).
RN   [9]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*06:02).
RX   PubMed=3259543; DOI=10.1007/bf00364432;
RA   Lock C.B., So A.K., Welsh K.I., Parkes J.D., Trowsdale J.;
RT   "MHC class II sequences of an HLA-DR2 narcoleptic.";
RL   Immunogenetics 27:449-455(1988).
RN   [10]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*03:03).
RX   PubMed=2050393; DOI=10.1007/bf00216702;
RA   Giorda R., Turco E., Trucco M.;
RT   "Full length beta chain cDNAs of DQw9 and DQw8 molecules encode proteins
RT   that differ only at amino acid 57.";
RL   Immunogenetics 33:404-408(1991).
RN   [11]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*06:12).
RX   PubMed=8988543; DOI=10.1111/j.1399-0039.1996.tb02674.x;
RA   Vilches C., Garcia-Pacheco J.M., de Pablo R., Puente S., Kreisler M.;
RT   "Complete coding region of the new HLA-DQB1*0612 allele, obtained by RT-
RT   PCR.";
RL   Tissue Antigens 48:589-592(1996).
RN   [12]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DQB1*02:01).
RX   PubMed=9271631; DOI=10.1007/s002510050295;
RA   Ellis M.C., Hetisimer A.H., Ruddy D.A., Hansen S.L., Kronmal G.S.,
RA   McClelland E., Quintana L., Drayna D.T., Aldrich M.S., Mignot E.;
RT   "HLA class II haplotype and sequence analysis support a role for DQ in
RT   narcolepsy.";
RL   Immunogenetics 46:410-417(1997).
RN   [13]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES DQB1*03:01 AND DQB1*03:03).
RX   PubMed=16140993; DOI=10.1101/gr.3554305;
RA   Raymond C.K., Kas A., Paddock M., Qiu R., Zhou Y., Subramanian S.,
RA   Chang J., Palmieri A., Haugen E., Kaul R., Olson M.V.;
RT   "Ancient haplotypes of the HLA Class II region.";
RL   Genome Res. 15:1250-1257(2005).
RN   [14]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELES DQB1*03:01; DQB1*04:01 AND DQB1*05:02).
RA   Kim E., Lee E., Kwack K.;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [15]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELES DQB1*02:02;
RP   DQB1*03:01 AND DQB1*03:03).
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [16]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE DQB1*03:02).
RC   TISSUE=B-cell;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [17]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-126 (ALLELE DQB1*06:02).
RX   PubMed=2925231; DOI=10.1007/bf00373644;
RA   Hiraiwa A., Seyfried C.E., Nepom G.T., Milner E.C.;
RT   "Sequence analysis of HLA class II domains: characterization of the DQw3
RT   family of DQB genes.";
RL   Immunogenetics 29:186-190(1989).
RN   [18]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 2-261 (ALLELE DQB1*03:01), AND NUCLEOTIDE
RP   SEQUENCE [MRNA] OF 33-261 (ALLELE DQB1*03:09).
RA   White J.M., Baxter-Lowe L.A.;
RT   "Nucleotide Deletions in a DQB1*0301 variant.";
RL   Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases.
RN   [19]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 10-126 (ALLELE DQB1*06:02).
RX   PubMed=2494138; DOI=10.1016/0198-8859(89)90058-x;
RA   Uryu N., Maeda M., Nagata Y., Matsuki K., Juji T., Honda Y., Kawai J.,
RA   Ando A., Tsuji K., Inoko H.;
RT   "No difference in the nucleotide sequence of the DQ beta beta 1 domain
RT   between narcoleptic and healthy individuals with DR2,Dw2.";
RL   Hum. Immunol. 24:175-181(1989).
RN   [20]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 33-261 (ALLELE DQB1*04:02).
RX   PubMed=2777341; DOI=10.1007/bf02421214;
RA   Jonsson A.-K., Andersson L., Rask L.;
RT   "Complete sequences of DQA1 and DQB1 cDNA clones corresponding to the DQw4
RT   specificity.";
RL   Immunogenetics 30:232-234(1989).
RN   [21]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 33-261 (ALLELES DQB1*03:03; DQB1*05:01;
RP   DQB1*05:03; DQB1*06:01; DQB1*06:02; DQB1*06:03 AND DQB1*06:04), AND
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 33-126 (ALLELE DQB1*03:01).
RX   PubMed=8929711; DOI=10.1111/j.1399-0039.1996.tb02512.x;
RA   Yasunaga S., Kimura A., Hamaguchi K., Ronningen K.S., Sasazuki T.;
RT   "Different contribution of HLA-DR and -DQ genes in susceptibility and
RT   resistance to insulin-dependent diabetes mellitus (IDDM).";
RL   Tissue Antigens 47:37-48(1996).
RN   [22]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 33-261 (ALLELE DQB1*03:10).
RX   PubMed=11098940; DOI=10.1034/j.1399-0039.2000.560412.x;
RA   Balas A., Santos S., Aviles M.J., Garcia-Sanchez F., Lillo R.,
RA   Vicario J.L.;
RT   "Identification by sequencing based typing and complete coding region
RT   analysis of three new HLA class II alleles: DRB3*0210, DRB3*0211 and
RT   DQB1*0310.";
RL   Tissue Antigens 56:380-384(2000).
RN   [23]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 33-261 (ALLELE DQB1*06:09).
RA   Yasunaga S.;
RL   Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases.
RN   [24]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 33-231 (ALLELES DQB1*03:04 AND
RP   DQB1*03:05).
RX   PubMed=7928445; DOI=10.1016/0198-8859(94)90060-4;
RA   Cucca F., Frau F., Lampis R., Floris M., Argiolas L., Macis D., Cao A.,
RA   De Virgiliis S., Congia M.;
RT   "HLA-DQB1*0305 and -DQB1*0304 alleles among Sardinians. Evolutionary and
RT   practical implications for oligotyping.";
RL   Hum. Immunol. 40:143-149(1994).
RN   [25]
RP   PROTEIN SEQUENCE OF 33-181 AND 200-230 (ALLELE DQB1*06:02).
RX   PubMed=6576979; DOI=10.1515/bchm2.1983.364.1.749;
RA   Goetz H., Kratzin H., Thinnes F.P., Yang C.-Y., Kruse T., Pauly E.,
RA   Koelbel S., Egert G., Wernet P., Hilschmann N.;
RT   "Primary structure of human class II histocompatibility antigens 3rd
RT   communication. Amino acid sequence comparison between DR and DC subclass
RT   antigens derived from a lymphoblastoid B cell line homozygous at the HLA
RT   loci (HLA-A3,3; B7,7; Dw2,2; DR2,2: MT1,1; Dc1,1: MB1,1).";
RL   Hoppe-Seyler's Z. Physiol. Chem. 364:749-755(1983).
RN   [26]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 33-140 (ALLELE DQB1*06:05).
RX   PubMed=2212675;
RA   Lee K.W., Johnson A.H., Hurley C.K.;
RT   "Two divergent routes of evolution gave rise to the DRw13 haplotypes.";
RL   J. Immunol. 145:3119-3125(1990).
RN   [27]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 33-126 (ALLELE DQB1*02:01).
RX   PubMed=3020127;
RA   Karr R.W., Gregersen P.K., Obata F., Goldberg D., Maccari J., Alber C.,
RA   Silver J.;
RT   "Analysis of DR-beta and DQ-beta chain cDNA clones from a DR7 haplotype.";
RL   J. Immunol. 137:2886-2890(1986).
RN   [28]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 33-126 (ALLELE DQB1*06:22).
RX   PubMed=17868257; DOI=10.1111/j.1399-0039.2007.00927.x;
RA   Chang Y., Fan T.X., Santana Z., Day N.K.;
RT   "Identification of a novel allele HLA-DQB1*0622.";
RL   Tissue Antigens 70:442-444(2007).
RN   [29]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 33-122 (ALLELE DQB1*06:02).
RX   PubMed=2886427; DOI=10.1007/bf00345459;
RA   Lee B.S., Bell J.I., Rust N.A., McDevitt H.O.;
RT   "Structural and functional variability among DQ beta alleles of DR2
RT   subtypes.";
RL   Immunogenetics 26:85-91(1987).
RN   [30]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 33-107 (ALLELE DQB1*03:07).
RX   PubMed=9174147; DOI=10.1111/j.1399-0039.1997.tb02789.x;
RA   Thye T., Muntau B., Stelma F.F., Horstmann R.D.;
RT   "A novel allele, DQB1*0307, in a West African family.";
RL   Tissue Antigens 49:517-518(1997).
RN   [31]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-126 (ALLELE DQB1*06:18).
RX   PubMed=11782280; DOI=10.1034/j.1399-0039.2001.580409.x;
RA   Casamitjana N., Gil J., Campos E., Santos M., Nogues N., Ribera A.,
RA   Palou E.;
RT   "Identification of a novel HLA-DQB1*06 allele, DQB1*0618.";
RL   Tissue Antigens 58:269-271(2001).
RN   [32]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-126 (ALLELE DQB1*06:19).
RA   Bowman S., Diviney M., Dunckley H., Holdsworth R., Varney M.;
RT   "A new DQB1*0602 variant found in Australian Caucasian.";
RL   Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
RN   [33]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-121 (ALLELE DQB1*06:13).
RX   PubMed=9458130; DOI=10.1111/j.1399-0039.1997.tb02935.x;
RA   Hsu S.H., Robbins F.M., Modelo R.B., Brunner J., Flomenberg N.;
RT   "Identification of a new DQB1*0613 allele in a family.";
RL   Tissue Antigens 50:685-687(1997).
RN   [34]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-257 (ALLELE DQB1*06:36).
RC   TISSUE=Peripheral blood;
RA   Skrablin P.S., Richter R., Seidl C., Seifried E.;
RT   "New HLA-DQB1*06 allele found in a voluntary blood stem cell donor.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [35]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*03:19).
RX   PubMed=17559588; DOI=10.1111/j.1399-0039.2007.00848.x;
RA   Witter K., Mautner J., Albert T., Zahn R., Kauke T.;
RT   "HLA-DQB1*0319, a novel HLA-DQB1 allele, shows strong haplotype association
RT   to HLA-DRB1*1102.";
RL   Tissue Antigens 70:73-75(2007).
RN   [36]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*06:34).
RX   PubMed=18331527; DOI=10.1111/j.1399-0039.2008.01021.x;
RA   Witter K., Albert T., Zahn R., Kauke T.;
RT   "HLA-DQB1*0634, a novel DQB1 allele found by high-resolution HLA typing of
RT   a sibling pair for potential bone marrow transplantation.";
RL   Tissue Antigens 71:486-488(2008).
RN   [37]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*03:21), AND
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELES DQB1*02:05 AND
RP   DQB1*03:20).
RX   PubMed=18588576; DOI=10.1111/j.1399-0039.2008.01070.x;
RA   Lazaro A.M., Xiao Y., Masaberg C., Lebeck L., Ng J., Hurley C.K.,
RA   Posch P.E.;
RT   "Novel alleles at the HLA-DRB1 and -DQB1 loci.";
RL   Tissue Antigens 72:72-74(2008).
RN   [38]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*03:22).
RC   TISSUE=Peripheral blood;
RX   PubMed=19254265; DOI=10.1111/j.1399-0039.2008.01201.x;
RA   Witter K., Lochmann E., Vecchiato C., Albert T., Zahn R., Kauke T.;
RT   "Sequence-based HLA high-resolution retyping of a bone marrow
RT   donor/recipient pair reveals the novel HLA allele DQB1*0322.";
RL   Tissue Antigens 73:283-285(2009).
RN   [39]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*03:23).
RC   TISSUE=Peripheral blood;
RX   PubMed=19493242; DOI=10.1111/j.1399-0039.2009.01231.x;
RA   Wienzek S., Verboom M., Blasczyk R., Bein G., Horn P.A.;
RT   "DQB1*0323 is the result of a gene conversion event between a DQB1*06 and a
RT   DQB1*030303 allele.";
RL   Tissue Antigens 73:624-625(2009).
RN   [40]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*02:04).
RA   Gragg H., Cordovado S.K., Hendrix M.M., Mueller P.W.;
RT   "Identification of a novel HLA-DQB1*02 allele.";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [41]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*03:25).
RA   Thompson E.M., Mehdizadeh Kashi Z., Martin R.K.;
RT   "Homo sapiens novel MHC class II HLA-DQB1 gene HLA-DQB1*03 novel allele,
RT   exons 2 and 3.";
RL   Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
RN   [42]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*03:24).
RA   Michaud C., Giannoli C., Favre Victoire I., Dubois V.;
RT   "A new HLA-DQB allele, identified by routine sequencing.";
RL   Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
RN   [43]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELES DQB1*06:38 AND
RP   DQB1*06:39).
RC   TISSUE=Blood;
RA   Anholts J.D.H.;
RT   "New alleles found during routine SBT HLA typing.";
RL   Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
RN   [44]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:10).
RX   PubMed=8896183; DOI=10.1111/j.1399-0039.1996.tb02633.x;
RA   Mersch G., Semana G., De Canck I., Jannes G., Rombout A., Sterker G.,
RA   Rossau R.;
RT   "Characterization of a new DQB1 allele (DQB1*0610) which differs from
RT   DQB1*0602 at the highly polymorphic 57-codon.";
RL   Tissue Antigens 48:217-220(1996).
RN   [45]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:06).
RC   TISSUE=Blood;
RX   PubMed=8988541; DOI=10.1111/j.1399-0039.1996.tb02672.x;
RA   Saito S., Ota S., Hashizume K., Yamada E., Kaneshige T., Hashimoto M.,
RA   Oguchi H., Ishii E., Fukushima H.;
RT   "A new HLA-DQB1*0306 allele sharing motifs from DQB1*03032 and DQB1*04
RT   sequences.";
RL   Tissue Antigens 48:580-585(1996).
RN   [46]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:11), AND
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-120 (ALLELE DQB1*06:20).
RX   PubMed=15361133; DOI=10.1111/j.1399-0039.2004.00307.x;
RA   Hogbin J.P., Greville W., Chapman G., Kennedy A., Velickovic Z.M.,
RA   Dunckley H.;
RT   "Identification of two novel HLA class II alleles, DQB1*0311 and
RT   DQB1*0620.";
RL   Tissue Antigens 64:515-517(2004).
RN   [47]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:16).
RA   Chen D.-F., DeOliveira A., Peplinski S., Herczyk W., Reinsmoen N.L.;
RT   "A novel DQB1*03 allele revealed by rSSOP and identified by SBT.";
RL   Hum. Immunol. 66:30-30(2005).
RN   [48]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:14).
RX   PubMed=15853909; DOI=10.1111/j.1399-0039.2005.00397.x;
RA   Gu H., Kimm K., Lee J.K., Oh B.;
RT   "Identification of a novel HLA-DQB1 allele, DQB1*0314, by sequence-based
RT   typing in the Korean population.";
RL   Tissue Antigens 65:503-504(2005).
RN   [49]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:28).
RX   PubMed=17212715; DOI=10.1111/j.1399-0039.2006.00733.x;
RA   Witter K., Albert T., Zahn R., Kauke T.;
RT   "A novel HLA-DQB1*06 allele, DQB1*0628, found through routine sequence-
RT   based HLA typing and confirmation of DQB1*060302.";
RL   Tissue Antigens 69:102-103(2007).
RN   [50]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:32).
RC   TISSUE=Blood;
RX   PubMed=17999653; DOI=10.1111/j.1399-0039.2007.00967.x;
RA   Emmerich F., Schonemann C., Diederich G., Horn P.A., Salama A.;
RT   "Identification of a novel HLA-DQB1 allele, HLA-DQB1*0632.";
RL   Tissue Antigens 71:94-95(2008).
RN   [51]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*05:05).
RX   PubMed=19392794; DOI=10.1111/j.1399-0039.2009.01248.x;
RA   Giannoli C., Paturel L., Favre-Victoire I., Bera O., Dubois V.;
RT   "Two new HLA-DQB alleles routinely identified by sequence-based typing:
RT   DQB1*030103 and DQB1*0505.";
RL   Tissue Antigens 73:622-623(2009).
RN   [52]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*02:03).
RA   Olerup O.H.;
RT   "A novel DQB1*02 allele.";
RL   Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases.
RN   [53]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:05).
RA   Rugg J., Blanton M., Whitacre L., Balakrishnan K., Lebeer K.,
RA   Van Reybroeck G., Mersch G.;
RT   "Detection of a new DQB1 allele.";
RL   Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
RN   [54]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:15).
RA   Shah A., Ross J., Chenery P., Holman R., Madrigal A., Little A.M.;
RT   "Two novel DQB1*06 alleles, identified by reverse line blot assay.";
RL   Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
RN   [55]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:05).
RC   TISSUE=Peripheral blood;
RA   Moine A.;
RT   "A new variant form of the HLA DQB1*0305 allele.";
RL   Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
RN   [56]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:12).
RA   Schwarz K., Zenz C.;
RT   "Homo sapiens HLA-DQB1*0312 allele, exon 2.";
RL   Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
RN   [57]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:13).
RA   Wu J., Bassinger S., Williams T.M.;
RT   "Novel human HLA-DQB1 allele identified in potential bone marrow donors.";
RL   Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
RN   [58]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:21).
RA   De Canck I.;
RT   "Identification of a new HLA-DQB1*06 allele by INNO-LiPA.";
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
RN   [59]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:17).
RA   Bassinger S., Wu J., Zhang Q., Brinkema C., Smith A.G., Williams T.M.;
RT   "Novel DQB1*06 alleles.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN   [60]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:23).
RA   Hirv K., Krauss A., Mytilineos J.;
RT   "Characterization of a new HLA-DQB1 allele by direct sequencing.";
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN   [61]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:15).
RC   TISSUE=Peripheral blood;
RA   Velickovic Z.M.;
RT   "Novel HLA-DQB1*03 allele.";
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
RN   [62]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:24).
RA   Schranz P., Seelig R., Seelig H.P.;
RT   "A new HLA-DQB1 allele.";
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [63]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:25).
RA   Watabe K., Hashimoto M.;
RT   "Homo sapiens HLA-DQ gene for MHC class2 antigen, partial cds, allele: HLA-
RT   DQB1*060401V.";
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [64]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:17).
RA   Chu C.-C.;
RT   "A novel DQB1 allele found in Taiwan.";
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [65]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:18).
RA   Hendrix M.M., Cordovado S.K., Mueller P.W.;
RT   "High resolution genotyping of HLA-DQB1 exon 2 and 3.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [66]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:29).
RA   Horn P.A., Blasczyk R.;
RT   "A novel HLA-DRQ1*06 allele.";
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN   [67]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:31).
RA   Nieberle I., Hirschmann D., Woelpl A.;
RT   "Identification of several new class I and II alleles in routine HLA-
RT   testing.";
RL   Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
RN   [68]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:33).
RA   Yu M., Hall J.E., Hartman K.J., Caparelli E., Czech J., Smyth E.,
RA   Jennings L.;
RT   "A novel HLA-DQB1*06 allele identified by PCR-SBT in a caucasian NMDP
RT   donor.";
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
RN   [69]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*04:03).
RA   Vigh A., Hirv K., Mytilineos J.;
RT   "Characterization of a new HLA-Cw*07 allele.";
RL   Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
RN   [70]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:37).
RA   Fuerst D., Mytilineos J.;
RT   "A new variant of HLA-DQB1*06.";
RL   Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
RN   [71]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:26).
RA   Yang K., Chen M.;
RT   "Novel DQB1*03 found in CAP test sample.";
RL   Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
RN   [72]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-122 (ALLELE DQB1*06:16).
RX   PubMed=10323344; DOI=10.1034/j.1399-0039.1999.530410.x;
RA   Luo M., Blanchard J., Maclean I., Brunham R.;
RT   "Identification of a novel DQB1 allele DBQ1*0616.";
RL   Tissue Antigens 53:381-382(1999).
RN   [73]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-115 (ALLELE DQB1*06:30).
RA   Rizzo M., Hurley C.K.;
RT   "Novel HLA-DQB1 allele.";
RL   Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [74]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-126 (ALLELE DQB1*06:14).
RC   TISSUE=Blood;
RX   PubMed=9802612; DOI=10.1111/j.1399-0039.1998.tb03047.x;
RA   Hashemi-tavoularis S., Ouellet S., Sengar D.P.S., Buyse I.M.;
RT   "A novel DRB3 allele (DRB3*0208), a new allelic variant of DRB1*1502
RT   (DRB1*15023) and two new DQB1 (DQB1*03012 and DQB1*0614) alleles.";
RL   Tissue Antigens 52:294-299(1998).
RN   [75]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-125 (ALLELE DQB1*06:11).
RX   PubMed=8896171; DOI=10.1111/j.1399-0039.1996.tb02621.x;
RA   Williams T.M., Bassinger S., Moehlenkamp C., Wu J., Montoya G.D.,
RA   Griffith B.B., McAuley J.D., Goldman S., Maurer D.H., Troup G.M.;
RT   "Strategy for distinguishing a new DQB1 allele (DQB1*0611) from the closely
RT   related DQB1*0602 allele via sequence specific PCR or direct DNA
RT   sequencing.";
RL   Tissue Antigens 48:143-147(1996).
RN   [76]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-125 (ALLELE DQB1*06:27).
RX   PubMed=16441489; DOI=10.1111/j.1399-0039.2006.00515.x;
RA   Brixner V., Mosebach M., Schmidt M., Hermann S., Seifried E., Martin H.,
RA   Seidl C.;
RT   "HLA-DRB1*0826 and HLA-DQB1*0627, two novel class II alleles identified in
RT   blood stem cell donors of Caucasian origin.";
RL   Tissue Antigens 67:160-162(2006).
RN   [77]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-122 (ALLELES DQB1*06:07 AND
RP   DQB1*06:08).
RA   Dinauer D.M., Hessner M.J.;
RL   Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
RN   [78]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-114 (ALLELE DQB1*05:04).
RX   PubMed=1440562; DOI=10.1111/j.1399-0039.1992.tb01958.x;
RA   Fenske T.S., Baxter-Lowe L.A.;
RT   "Two novel HLA-DQB1*06 alleles reveal additional heterogeneity of HLA-
RT   DQw1.";
RL   Tissue Antigens 40:49-52(1992).
RN   [79]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 53-109 (ALLELE DQB1*02:01).
RX   PubMed=2308943; DOI=10.1073/pnas.87.5.1835;
RA   Gyllensten U.B., Lashkari D., Erlich H.A.;
RT   "Allelic diversification at the class II DQB locus of the mammalian major
RT   histocompatibility complex.";
RL   Proc. Natl. Acad. Sci. U.S.A. 87:1835-1839(1990).
RN   [80]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 53-109 (ALLELES DQB1*02:01 AND
RP   DQB1*06:02).
RX   PubMed=2010218; DOI=10.1007/bf01719235;
RA   Bugawan T.L., Erlich H.A.;
RT   "Rapid typing of HLA-DQB1 DNA polymorphism using nonradioactive
RT   oligonucleotide probes and amplified DNA.";
RL   Immunogenetics 33:163-170(1991).
RN   [81]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 135-217 (ALLELE DQB1*02:01).
RX   PubMed=6952552; DOI=10.1111/j.1365-3083.1981.tb00603.x;
RA   Larhammar D., Wiman K., Schenning L., Claesson L., Gustafsson K.,
RA   Peterson P.A., Rask L.;
RT   "Evolutionary relationship between HLA-DR antigen beta-chains, HLA-A, B, C
RT   antigen subunits and immunoglobulin chains.";
RL   Scand. J. Immunol. 14:617-622(1981).
RN   [82]
RP   POLYMORPHISM.
RX   PubMed=18565458; DOI=10.1016/s1474-4422(08)70140-6;
RA   Bourgin P., Zeitzer J.M., Mignot E.;
RT   "CSF hypocretin-1 assessment in sleep and neurological disorders.";
RL   Lancet Neurol. 7:649-662(2008).
RN   [83]
RP   REVIEW.
RX   PubMed=8598037; DOI=10.1016/s0092-8674(00)81025-9;
RA   Cresswell P.;
RT   "Invariant chain structure and MHC class II function.";
RL   Cell 84:505-507(1996).
RN   [84]
RP   REVIEW.
RX   PubMed=11684289; DOI=10.1016/s0161-5890(01)00069-4;
RA   Villadangos J.A.;
RT   "Presentation of antigens by MHC class II molecules: getting the most out
RT   of them.";
RL   Mol. Immunol. 38:329-346(2001).
RN   [85]
RP   REVIEW.
RX   PubMed=18046453; DOI=10.1038/sj.emboj.7601945;
RA   Rocha N., Neefjes J.;
RT   "MHC class II molecules on the move for successful antigen presentation.";
RL   EMBO J. 27:1-5(2008).
RN   [86]
RP   REVIEW.
RX   PubMed=17241953; DOI=10.1016/j.immuni.2007.01.005;
RA   Menendez-Benito V., Neefjes J.;
RT   "Autophagy in MHC class II presentation: sampling from within.";
RL   Immunity 26:1-3(2007).
RN   [87]
RP   REVIEW.
RX   PubMed=19092054; DOI=10.1242/jcs.035089;
RA   Berger A.C., Roche P.A.;
RT   "MHC class II transport at a glance.";
RL   J. Cell Sci. 122:1-4(2009).
RN   [88]
RP   REVIEW.
RX   PubMed=19533806; DOI=10.3748/wjg.15.2855;
RA   Beswick E.J., Reyes V.E.;
RT   "CD74 in antigen presentation, inflammation, and cancers of the
RT   gastrointestinal tract.";
RL   World J. Gastroenterol. 15:2855-2861(2009).
RN   [89]
RP   X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 35-224 OF HLA-DQA1/HLA-DQB1
RP   HETERODIMER IN COMPLEX WITH INS PEPTIDE, SUBUNIT, AND DISULFIDE BONDS.
RX   PubMed=11376336; DOI=10.1038/88694;
RA   Lee K.H., Wucherpfennig K.W., Wiley D.C.;
RT   "Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to
RT   type 1 diabetes.";
RL   Nat. Immunol. 2:501-507(2001).
RN   [90]
RP   X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 35-231 OF HLA-DQA1/HLA-DQB1
RP   HETERODIMER (HLA-DQ0602) IN COMPLEX WITH HCRT PEPTIDE, POLYMORPHISM,
RP   SUBUNIT, AND DISULFIDE BONDS.
RX   PubMed=14769912; DOI=10.1073/pnas.0308458100;
RA   Siebold C., Hansen B.E., Wyer J.R., Harlos K., Esnouf R.E., Svejgaard A.,
RA   Bell J.I., Strominger J.L., Jones E.Y., Fugger L.;
RT   "Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and
RT   confers strong susceptibility to narcolepsy.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:1999-2004(2004).
RN   [91]
RP   X-RAY CRYSTALLOGRAPHY (2.22 ANGSTROMS) OF 33-230 OF HLA-DQA1/HLA-DQB1
RP   HETERODIMER (DQ2) IN COMPLEX WITH TRITICUM AESTIVUM ALPHA/BETA-GLIADIN
RP   PEPTIDE, SUBUNIT, AND POLYMORPHISM.
RX   PubMed=15020763; DOI=10.1073/pnas.0306885101;
RA   Kim C.Y., Quarsten H., Bergseng E., Khosla C., Sollid L.M.;
RT   "Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in
RT   celiac disease.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:4175-4179(2004).
RN   [92]
RP   X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 33-224 OF HLA-DQA1/HLA-DQB1
RP   HETERODIMER IN COMPLEX WITH TRITICUM AESTIVUM ALPHA/BETA-GLIADIN PEPTIDE,
RP   POLYMORPHISM, SUBUNIT, AND DISULFIDE BONDS.
RX   PubMed=17629515; DOI=10.1016/j.immuni.2007.05.015;
RA   Henderson K.N., Tye-Din J.A., Reid H.H., Chen Z., Borg N.A., Beissbarth T.,
RA   Tatham A., Mannering S.I., Purcell A.W., Dudek N.L., van Heel D.A.,
RA   McCluskey J., Rossjohn J., Anderson R.P.;
RT   "A structural and immunological basis for the role of human leukocyte
RT   antigen DQ8 in celiac disease.";
RL   Immunity 27:23-34(2007).
RN   [93]
RP   VARIANT [LARGE SCALE ANALYSIS] ALA-172, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
CC   -!- FUNCTION: Binds peptides derived from antigens that access the
CC       endocytic route of antigen presenting cells (APC) and presents them on
CC       the cell surface for recognition by the CD4 T-cells. The peptide
CC       binding cleft accommodates peptides of 10-30 residues. The peptides
CC       presented by MHC class II molecules are generated mostly by degradation
CC       of proteins that access the endocytic route, where they are processed
CC       by lysosomal proteases and other hydrolases. Exogenous antigens that
CC       have been endocytosed by the APC are thus readily available for
CC       presentation via MHC II molecules, and for this reason this antigen
CC       presentation pathway is usually referred to as exogenous. As membrane
CC       proteins on their way to degradation in lysosomes as part of their
CC       normal turn-over are also contained in the endosomal/lysosomal
CC       compartments, exogenous antigens must compete with those derived from
CC       endogenous components. Autophagy is also a source of endogenous
CC       peptides, autophagosomes constitutively fuse with MHC class II loading
CC       compartments. In addition to APCs, other cells of the gastrointestinal
CC       tract, such as epithelial cells, express MHC class II molecules and
CC       CD74 and act as APCs, which is an unusual trait of the GI tract. To
CC       produce a MHC class II molecule that presents an antigen, three MHC
CC       class II molecules (heterodimers of an alpha and a beta chain)
CC       associate with a CD74 trimer in the ER to form a heterononamer. Soon
CC       after the entry of this complex into the endosomal/lysosomal system
CC       where antigen processing occurs, CD74 undergoes a sequential
CC       degradation by various proteases, including CTSS and CTSL, leaving a
CC       small fragment termed CLIP (class-II-associated invariant chain
CC       peptide). The removal of CLIP is facilitated by HLA-DM via direct
CC       binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM
CC       stabilizes MHC class II molecules until primary high affinity antigenic
CC       peptides are bound. The MHC II molecule bound to a peptide is then
CC       transported to the cell membrane surface. In B-cells, the interaction
CC       between HLA-DM and MHC class II molecules is regulated by HLA-DO.
CC       Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal
CC       microenvironment has been implicated in the regulation of antigen
CC       loading into MHC II molecules, increased acidification produces
CC       increased proteolysis and efficient peptide loading.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta subunit; also referred as
CC       MHC class II molecule. In the endoplasmic reticulum (ER) it forms a
CC       heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also
CC       known as invariant chain or HLA class II histocompatibility antigen
CC       gamma chain). In the endosomal/lysosomal system; CD74 undergoes
CC       sequential degradation by various proteases; leaving a small fragment
CC       termed CLIP on each MHC class II molecule. MHC class II molecule
CC       interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP
CC       and facilitate the binding of antigenic peptides.
CC       {ECO:0000269|PubMed:11376336, ECO:0000269|PubMed:14769912,
CC       ECO:0000269|PubMed:15020763, ECO:0000269|PubMed:17629515}.
CC   -!- INTERACTION:
CC       P01920; P01909: HLA-DQA1; NbExp=8; IntAct=EBI-1038012, EBI-713389;
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
CC       protein. Endoplasmic reticulum membrane; Single-pass type I membrane
CC       protein. Golgi apparatus, trans-Golgi network membrane; Single-pass
CC       type I membrane protein. Endosome membrane; Single-pass type I membrane
CC       protein. Lysosome membrane; Single-pass type I membrane protein.
CC       Note=The MHC class II complex transits through a number of
CC       intracellular compartments in the endocytic pathway until it reaches
CC       the cell membrane for antigen presentation.
CC   -!- POLYMORPHISM: The following alleles of HLA-DQB1 are known: DQB1*02:01,
CC       DQB1*02:02, DQB1*02:03, DQB1*02:04, DQB1*02:05, DQB1*03:01, DQB1*03:02,
CC       DQB1*03:03, DQB1*03:04, DQB1*03:05, DQB1*03:06, DQB1*03:07, DQB1*03:08,
CC       DQB1*03:09, DQB1*03:10, DQB1*03:11, DQB1*03:12, DQB1*03:13, DQB1*03:14,
CC       DQB1*03:15, DQB1*03:16, DQB1*03:17, DQB1*03:18, DQB1*03:19, DQB1*03:20,
CC       DQB1*03:21, DQB1*03:22, DQB1*03:23, DQB1*03:24, DQB1*03:25, DQB1*03:26,
CC       DQB1*04:01, DQB1*04:02, DQB1*04:03, DQB1*05:01, DQB1*05:02, DQB1*05:03,
CC       DQB1*05:04, DQB1*05:05, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04,
CC       DQB1*06:05, DQB1*06:06, DQB1*06:07, DQB1*06:08, DQB1*06:09, DQB1*06:10,
CC       DQB1*06:11, DQB1*06:12, DQB1*06:13, DQB1*06:14, DQB1*06:15, DQB1*06:16,
CC       DQB1*06:17, DQB1*06:18, DQB1*06:19, DQB1*06:20, DQB1*06:21, DQB1*06:22,
CC       DQB1*06:23, DQB1*06:24, DQB1*06:25, DQB1*06:27, DQB1*06:28, DQB1*06:29,
CC       DQB1*06:30, DQB1*06:31, DQB1*06:32, DQB1*06:33, DQB1*06:34, DQB1*06:35,
CC       DQB1*06:36, DQB1*06:37, DQB1*06:38, and DQB1*06:39. The sequence shown
CC       is that of DQB1*03:01.
CC   -!- POLYMORPHISM: DQ2 (heterodimer of DQA1*05:01/DQB1*02:01) is associated
CC       with more than 90% of celiac disease patients. A minority displays DQ8
CC       (heterodimer of DQA1*03/DQB1*03:02).
CC   -!- POLYMORPHISM: DQ0602 (heterodimer of DQA1*01:02/DQB1*06:02) confers
CC       dominant protection against type 1 diabetes (T1D) and strong
CC       susceptibility to narcolepsy. DQB1*06:02 has been found to be present
CC       in most of the narcolepsy patients. As well 98% of the patients with an
CC       HCRT deficiency are positive for DQB1*06:02.
CC   -!- SIMILARITY: Belongs to the MHC class II family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC64403.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=CAJ57391.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; K01499; AAA98746.1; -; Genomic_DNA.
DR   EMBL; K02405; AAA75521.1; -; Genomic_DNA.
DR   EMBL; X03068; CAA26872.1; -; mRNA.
DR   EMBL; M17564; AAA59765.1; -; mRNA.
DR   EMBL; M29613; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; M29616; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; M16996; AAA59770.1; -; mRNA.
DR   EMBL; M20432; AAA59769.1; -; mRNA.
DR   EMBL; M60028; AAA59755.1; -; mRNA.
DR   EMBL; X96420; CAA65280.1; -; mRNA.
DR   EMBL; U92032; AAB91991.1; -; Genomic_DNA.
DR   EMBL; AY663393; AAU87973.1; -; Genomic_DNA.
DR   EMBL; AY663394; AAU87977.1; -; Genomic_DNA.
DR   EMBL; AY663397; AAU87986.1; -; Genomic_DNA.
DR   EMBL; AY663409; AAU88017.1; -; Genomic_DNA.
DR   EMBL; AY663404; AAU88002.1; -; Genomic_DNA.
DR   EMBL; AY663410; AAU88020.1; -; Genomic_DNA.
DR   EMBL; AY663412; AAU88027.1; -; Genomic_DNA.
DR   EMBL; AY656681; AAV71028.1; -; mRNA.
DR   EMBL; AY656682; AAV71029.1; -; mRNA.
DR   EMBL; AY656683; AAV71030.1; -; mRNA.
DR   EMBL; BX927168; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR753846; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR933859; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC012106; AAH12106.1; -; mRNA.
DR   EMBL; M25327; AAA59677.1; -; mRNA.
DR   EMBL; U66400; AAB51698.1; -; mRNA.
DR   EMBL; U83582; AAB41231.1; -; mRNA.
DR   EMBL; AH002887; AAA59762.1; -; Genomic_DNA.
DR   EMBL; M26042; AAA36270.1; -; mRNA.
DR   EMBL; M33907; AAA52672.1; -; mRNA.
DR   EMBL; L34096; AAC41964.1; -; mRNA.
DR   EMBL; L34098; AAC41966.1; -; mRNA.
DR   EMBL; L34101; AAC41969.1; -; mRNA.
DR   EMBL; L34103; AAC41971.1; -; mRNA.
DR   EMBL; L34104; AAC41972.1; -; mRNA.
DR   EMBL; L34105; AAC41973.1; -; mRNA.
DR   EMBL; L34106; AAC41974.1; -; mRNA.
DR   EMBL; L34107; AAC41975.1; -; mRNA.
DR   EMBL; AF195245; AAF28315.1; -; mRNA.
DR   EMBL; L42626; AAA85335.1; -; mRNA.
DR   EMBL; X76553; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; X76554; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; M59800; AAA64235.1; -; mRNA.
DR   EMBL; M14189; AAA36268.1; -; mRNA.
DR   EMBL; AY672649; AAT77952.1; -; Genomic_DNA.
DR   EMBL; M17207; AAA59697.1; -; mRNA.
DR   EMBL; Z49215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AY026349; AAK01944.1; -; Genomic_DNA.
DR   EMBL; AF091305; AAC64403.2; ALT_SEQ; Genomic_DNA.
DR   EMBL; U77344; AAB19215.1; -; Genomic_DNA.
DR   EMBL; FN256435; CAX62164.1; -; Genomic_DNA.
DR   EMBL; FN256435; CAX62165.1; -; Genomic_DNA.
DR   EMBL; AM400970; CAL47037.1; -; Genomic_DNA.
DR   EMBL; AM421131; CAM07104.1; -; Genomic_DNA.
DR   EMBL; EF484936; ABO87661.1; -; Genomic_DNA.
DR   EMBL; EF484939; ABO87664.1; -; Genomic_DNA.
DR   EMBL; EU275158; ABY26531.1; -; Genomic_DNA.
DR   EMBL; AM944346; CAQ16179.1; -; Genomic_DNA.
DR   EMBL; FM200854; CAR31119.1; -; Genomic_DNA.
DR   EMBL; AH013029; AAP93137.1; -; Genomic_DNA.
DR   EMBL; EU770203; ACF16333.1; -; Genomic_DNA.
DR   EMBL; FM955320; CAW24712.1; -; Genomic_DNA.
DR   EMBL; FN552709; CBF35736.1; -; Genomic_DNA.
DR   EMBL; FN552710; CBF35739.1; -; Genomic_DNA.
DR   EMBL; X86327; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; D78569; BAA11413.1; -; Genomic_DNA.
DR   EMBL; AF439338; AAL35222.1; -; Genomic_DNA.
DR   EMBL; AF384556; AAM53072.1; -; Genomic_DNA.
DR   EMBL; DQ026226; AAY89656.1; -; Genomic_DNA.
DR   EMBL; AY762968; AAV97949.1; -; Genomic_DNA.
DR   EMBL; AM181332; CAJ57391.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AM691798; CAM88661.1; -; Genomic_DNA.
DR   EMBL; AM259942; CAJ90956.1; -; Genomic_DNA.
DR   EMBL; U39090; AAB02681.1; -; Genomic_DNA.
DR   EMBL; AJ003005; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJ012156; CAA09929.1; -; Genomic_DNA.
DR   EMBL; AJ290396; CAC27418.1; -; Genomic_DNA.
DR   EMBL; AF469118; AAL77085.1; -; Genomic_DNA.
DR   EMBL; AF479569; AAM09472.1; -; Genomic_DNA.
DR   EMBL; AJ535315; CAD59445.2; -; Genomic_DNA.
DR   EMBL; AF181983; AAD54423.2; -; Genomic_DNA.
DR   EMBL; AY733062; AAU33811.1; -; Genomic_DNA.
DR   EMBL; AJ854065; CAH69441.1; -; Genomic_DNA.
DR   EMBL; AJ964903; CAI79639.1; -; Genomic_DNA.
DR   EMBL; AB211231; BAD95610.1; -; Genomic_DNA.
DR   EMBL; DQ114427; AAZ20753.1; -; Genomic_DNA.
DR   EMBL; DQ227421; ABB05231.1; -; Genomic_DNA.
DR   EMBL; AM403489; CAL48285.1; -; Genomic_DNA.
DR   EMBL; AM490069; CAM32717.1; -; Genomic_DNA.
DR   EMBL; EF622510; ABR24117.1; -; Genomic_DNA.
DR   EMBL; EU410617; ABZ89500.1; -; Genomic_DNA.
DR   EMBL; GQ422610; ACV66342.1; -; Genomic_DNA.
DR   EMBL; FN550110; CBE66554.1; -; Genomic_DNA.
DR   EMBL; AF087939; AAD39697.1; -; Genomic_DNA.
DR   EMBL; AY094140; AAM14401.1; -; Genomic_DNA.
DR   EMBL; AJ001257; CAA04631.1; -; Genomic_DNA.
DR   EMBL; U39086; AAA93181.1; -; Genomic_DNA.
DR   EMBL; AJ965439; CAI84643.1; -; Genomic_DNA.
DR   EMBL; AF112463; AAD23990.1; -; Genomic_DNA.
DR   EMBL; AF112464; AAD23991.1; -; Genomic_DNA.
DR   EMBL; M94773; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; M65042; AAA36241.1; -; Genomic_DNA.
DR   EMBL; M25025; AAA59793.1; -; mRNA.
DR   PIR; A02234; HLHU1C.
DR   PIR; A35055; A35055.
DR   PIR; A94003; HLHUDB.
DR   PIR; B32527; B32527.
DR   PIR; B37044; B37044.
DR   PIR; C24669; HLHU2C.
DR   PIR; F30575; F30575.
DR   PIR; I54480; I54480.
DR   PIR; I68732; I68732.
DR   PIR; I72482; I72482.
DR   PIR; S46648; S46648.
DR   RefSeq; NP_001230891.1; NM_001243962.1.
DR   RefSeq; NP_002114.3; NM_002123.4.
DR   PDB; 1JK8; X-ray; 2.40 A; B=35-224.
DR   PDB; 1S9V; X-ray; 2.22 A; B/E=33-230.
DR   PDB; 1UVQ; X-ray; 1.80 A; B=35-230.
DR   PDB; 2NNA; X-ray; 2.10 A; B=33-224.
DR   PDB; 4GG6; X-ray; 3.20 A; B/D=33-224.
DR   PDB; 4OZF; X-ray; 2.70 A; B=33-224.
DR   PDB; 4OZG; X-ray; 3.00 A; B/D=33-224.
DR   PDB; 4OZH; X-ray; 2.80 A; B/D=33-224.
DR   PDB; 4OZI; X-ray; 3.20 A; B/D=33-224.
DR   PDBsum; 1JK8; -.
DR   PDBsum; 1S9V; -.
DR   PDBsum; 1UVQ; -.
DR   PDBsum; 2NNA; -.
DR   PDBsum; 4GG6; -.
DR   PDBsum; 4OZF; -.
DR   PDBsum; 4OZG; -.
DR   PDBsum; 4OZH; -.
DR   PDBsum; 4OZI; -.
DR   AlphaFoldDB; P01920; -.
DR   SMR; P01920; -.
DR   BioGRID; 109364; 116.
DR   IntAct; P01920; 3.
DR   MINT; P01920; -.
DR   STRING; 9606.ENSP00000364080; -.
DR   TCDB; 9.A.75.1.1; the mhc ii receptor (mhc2r) family.
DR   GlyGen; P01920; 2 sites.
DR   iPTMnet; P01920; -.
DR   PhosphoSitePlus; P01920; -.
DR   BioMuta; HLA-DQB1; -.
DR   DMDM; 290457643; -.
DR   jPOST; P01920; -.
DR   MassIVE; P01920; -.
DR   PeptideAtlas; P01920; -.
DR   PRIDE; P01920; -.
DR   ProteomicsDB; 51513; -.
DR   ABCD; P01920; 2 sequenced antibodies.
DR   CPTC; P01920; 1 antibody.
DR   DNASU; 3119; -.
DR   Ensembl; ENST00000399088.8; ENSP00000382038.4; ENSG00000231286.7.
DR   Ensembl; ENST00000413089.1; ENSP00000396539.1; ENSG00000231286.7.
DR   Ensembl; ENST00000416192.6; ENSP00000410107.2; ENSG00000233209.6.
DR   Ensembl; ENST00000419914.6; ENSP00000402865.2; ENSG00000225824.8.
DR   Ensembl; ENST00000422950.1; ENSP00000414079.1; ENSG00000233209.6.
DR   Ensembl; ENST00000424806.1; ENSP00000410330.1; ENSG00000225824.8.
DR   GeneID; 3119; -.
DR   KEGG; hsa:3119; -.
DR   UCSC; uc011hep.3; human.
DR   CTD; 3119; -.
DR   DisGeNET; 3119; -.
DR   GeneCards; HLA-DQB1; -.
DR   GeneReviews; HLA-DQB1; -.
DR   HGNC; HGNC:4944; HLA-DQB1.
DR   MalaCards; HLA-DQB1; -.
DR   MIM; 604305; gene.
DR   neXtProt; NX_P01920; -.
DR   Orphanet; 703; Bullous pemphigoid.
DR   Orphanet; 930; Idiopathic achalasia.
DR   Orphanet; 2073; Narcolepsy type 1.
DR   Orphanet; 83465; Narcolepsy type 2.
DR   Orphanet; 555; NON RARE IN EUROPE: Celiac disease.
DR   Orphanet; 243377; NON RARE IN EUROPE: Diabetes mellitus type 1.
DR   Orphanet; 802; NON RARE IN EUROPE: Multiple sclerosis.
DR   Orphanet; 477738; Pediatric multiple sclerosis.
DR   PharmGKB; PA35068; -.
DR   eggNOG; ENOG502RYBQ; Eukaryota.
DR   InParanoid; P01920; -.
DR   OrthoDB; 1186163at2759; -.
DR   PhylomeDB; P01920; -.
DR   PathwayCommons; P01920; -.
DR   Reactome; R-HSA-202424; Downstream TCR signaling.
DR   Reactome; R-HSA-202427; Phosphorylation of CD3 and TCR zeta chains.
DR   Reactome; R-HSA-202430; Translocation of ZAP-70 to Immunological synapse.
DR   Reactome; R-HSA-202433; Generation of second messenger molecules.
DR   Reactome; R-HSA-2132295; MHC class II antigen presentation.
DR   Reactome; R-HSA-389948; PD-1 signaling.
DR   Reactome; R-HSA-877300; Interferon gamma signaling.
DR   SignaLink; P01920; -.
DR   SIGNOR; P01920; -.
DR   BioGRID-ORCS; 3119; 10 hits in 997 CRISPR screens.
DR   ChiTaRS; HLA-DQB1; human.
DR   EvolutionaryTrace; P01920; -.
DR   GeneWiki; HLA-DQB1; -.
DR   GenomeRNAi; 3119; -.
DR   Pharos; P01920; Tbio.
DR   PRO; PR:P01920; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; P01920; protein.
DR   Bgee; ENSG00000231286; Expressed in spleen and 10 other tissues.
DR   GO; GO:0030669; C:clathrin-coated endocytic vesicle membrane; TAS:Reactome.
DR   GO; GO:0030666; C:endocytic vesicle membrane; TAS:Reactome.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome.
DR   GO; GO:0000139; C:Golgi membrane; TAS:Reactome.
DR   GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome.
DR   GO; GO:0005765; C:lysosomal membrane; TAS:Reactome.
DR   GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR   GO; GO:0042613; C:MHC class II protein complex; ISS:CAFA.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0032588; C:trans-Golgi network membrane; TAS:Reactome.
DR   GO; GO:0030658; C:transport vesicle membrane; TAS:Reactome.
DR   GO; GO:0023026; F:MHC class II protein complex binding; IBA:GO_Central.
DR   GO; GO:0032395; F:MHC class II receptor activity; NAS:UniProtKB.
DR   GO; GO:0042605; F:peptide antigen binding; ISS:CAFA.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IDA:UniProtKB.
DR   GO; GO:0006959; P:humoral immune response; IMP:UniProtKB.
DR   GO; GO:0006955; P:immune response; NAS:UniProtKB.
DR   GO; GO:0002503; P:peptide antigen assembly with MHC class II protein complex; IBA:GO_Central.
DR   GO; GO:0050870; P:positive regulation of T cell activation; IBA:GO_Central.
DR   GO; GO:0050852; P:T cell receptor signaling pathway; IDA:UniProtKB.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 3.10.320.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR014745; MHC_II_a/b_N.
DR   InterPro; IPR000353; MHC_II_b_N.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00969; MHC_II_beta; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SMART; SM00921; MHC_II_beta; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   SUPFAM; SSF54452; SSF54452; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Adaptive immunity; Cell membrane; Direct protein sequencing;
KW   Disulfide bond; Endoplasmic reticulum; Endosome; Glycoprotein;
KW   Golgi apparatus; Immunity; Lysosome; Membrane; MHC II; Reference proteome;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000269|PubMed:6576979"
FT   CHAIN           33..261
FT                   /note="HLA class II histocompatibility antigen, DQ beta 1
FT                   chain"
FT                   /id="PRO_0000018989"
FT   TOPO_DOM        33..230
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        231..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        252..261
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          129..217
FT                   /note="Ig-like C1-type"
FT   REGION          33..126
FT                   /note="Beta-1"
FT   REGION          127..220
FT                   /note="Beta-2"
FT   REGION          221..230
FT                   /note="Connecting peptide"
FT   CARBOHYD        51
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        47..111
FT   DISULFID        149..205
FT   VARIANT         6
FT                   /note="A -> S (in allele DQB1*05:01 and allele DQB1*05:02;
FT                   dbSNP:rs1049056)"
FT                   /id="VAR_056570"
FT   VARIANT         12
FT                   /note="G -> D (in allele DQB1*05:01, allele DQB1*05:02,
FT                   allele DQB1*06:02 and allele DQB1*06:12; dbSNP:rs1049057)"
FT                   /id="VAR_062679"
FT   VARIANT         15
FT                   /note="A -> V (in allele DQB1*03:02, allele DQB1*03:03,
FT                   allele DQB1*04:01, allele DQB1*05:01, allele DQB1*05:02,
FT                   allele DQB1*06:02 and allele DQB1*06:12; dbSNP:rs3189152)"
FT                   /evidence="ECO:0000269|PubMed:3584986"
FT                   /id="VAR_062680"
FT   VARIANT         23
FT                   /note="A -> S (in allele DQB1*02:01 and allele DQB1*02:02;
FT                   dbSNP:rs3891176)"
FT                   /id="VAR_062681"
FT   VARIANT         24
FT                   /note="M -> I (in allele DQB1*05:01 and allele DQB1*05:02;
FT                   dbSNP:rs1049059)"
FT                   /id="VAR_062682"
FT   VARIANT         27
FT                   /note="T -> A (in allele DQB1*04:01; dbSNP:rs1049060)"
FT                   /id="VAR_062683"
FT   VARIANT         27
FT                   /note="T -> S (in allele DQB1*05:01, allele DQB1*05:02,
FT                   allele DQB1*06:02 and allele DQB1*06:12; dbSNP:rs1049060)"
FT                   /id="VAR_062684"
FT   VARIANT         28
FT                   /note="P -> L (in allele DQB1*06:02 and allele DQB1*06:12;
FT                   dbSNP:rs1049062)"
FT                   /id="VAR_062685"
FT   VARIANT         28
FT                   /note="P -> S (in allele DQB1*05:01 and allele DQB1*05:02;
FT                   dbSNP:rs1049061)"
FT                   /evidence="ECO:0000269|PubMed:3584986"
FT                   /id="VAR_062686"
FT   VARIANT         29
FT                   /note="V -> L (in allele DQB1*05:01, allele DQB1*05:02,
FT                   allele DQB1*06:02 and allele DQB1*06:12; dbSNP:rs1130366)"
FT                   /id="VAR_062687"
FT   VARIANT         35
FT                   /note="S -> P (in allele DQB1*06:01; dbSNP:rs12722106)"
FT                   /id="VAR_062688"
FT   VARIANT         41
FT                   /note="Y -> F (in allele DQB1*04:01, allele DQB1*04:02,
FT                   allele DQB1*04:03, allele DQB1*06:02, allele DQB1*06:10,
FT                   allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15,
FT                   allele DQB1*06:16, allele DQB1*06:19, allele DQB1*06:20,
FT                   allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24,
FT                   allele DQB1*06:29, allele DQB1*06:33 and allele DQB1*06:37;
FT                   dbSNP:rs9274407)"
FT                   /id="VAR_062689"
FT   VARIANT         41
FT                   /note="Y -> L (in allele DQB1*06:01 and allele DQB1*06:35;
FT                   requires 2 nucleotide substitutions)"
FT                   /id="VAR_062690"
FT   VARIANT         43
FT                   /note="F -> L (in allele DQB1*06:33; dbSNP:rs56173496)"
FT                   /id="VAR_062691"
FT   VARIANT         45
FT                   /note="A -> G (in allele DQB1*02:01, allele DQB1*02:02,
FT                   allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05,
FT                   allele DQB1*03:02, allele DQB1*03:03, allele DQB1*03:05,
FT                   allele DQB1*03:06, allele DQB1*03:07, allele DQB1*03:08,
FT                   allele DQB1*03:11, allele DQB1*03:15, allele DQB1*03:17,
FT                   allele DQB1*03:18, allele DQB1*03:20, allele DQB1*03:23,
FT                   allele DQB1*03:25, allele DQB1*03:26, allele DQB1*04:01,
FT                   allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:01,
FT                   allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04,
FT                   allele DQB1*05:05, allele DQB1*06:02, allele DQB1*06:03,
FT                   allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07,
FT                   allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10,
FT                   allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13,
FT                   allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16,
FT                   allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19,
FT                   allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:22,
FT                   allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25,
FT                   allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29,
FT                   allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32,
FT                   allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:36,
FT                   allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39;
FT                   dbSNP:rs1130375)"
FT                   /evidence="ECO:0000269|PubMed:3584986"
FT                   /id="VAR_061472"
FT   VARIANT         46
FT                   /note="M -> L (in allele DQB1*03:11, allele DQB1*03:26,
FT                   allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03,
FT                   allele DQB1*05:04, allele DQB1*05:05, allele DQB1*06:05,
FT                   allele DQB1*06:20 and allele DQB1*06:31; dbSNP:rs1130368)"
FT                   /id="VAR_061473"
FT   VARIANT         55
FT                   /note="R -> L (in allele DQB1*04:01; dbSNP:rs41540813)"
FT                   /id="VAR_062692"
FT   VARIANT         58
FT                   /note="Y -> G (in allele DQB1*03:05, allele DQB1*03:17,
FT                   allele DQB1*04:01, allele DQB1*04:02, allele DQB1*05:01,
FT                   allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04,
FT                   allele DQB1*05:05 and allele DQB1*06:23; requires 2
FT                   nucleotide substitutions)"
FT                   /id="VAR_062693"
FT   VARIANT         58
FT                   /note="Y -> L (in allele DQB1*02:01, allele DQB1*02:02,
FT                   allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05,
FT                   allele DQB1*03:02, allele DQB1*03:03, allele DQB1*03:06,
FT                   allele DQB1*03:07, allele DQB1*03:08, allele DQB1*03:11,
FT                   allele DQB1*03:12, allele DQB1*03:15, allele DQB1*03:18,
FT                   allele DQB1*03:20, allele DQB1*03:23, allele DQB1*03:25,
FT                   allele DQB1*03:26, allele DQB1*04:03, allele DQB1*06:02,
FT                   allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05,
FT                   allele DQB1*06:06, allele DQB1*06:07, allele DQB1*06:08,
FT                   allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11,
FT                   allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14,
FT                   allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17,
FT                   allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20,
FT                   allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:24,
FT                   allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28,
FT                   allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31,
FT                   allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34,
FT                   allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and
FT                   allele DQB1*06:39; requires 2 nucleotide substitutions;
FT                   dbSNP:rs766817072)"
FT                   /evidence="ECO:0000269|PubMed:3584986"
FT                   /id="VAR_062694"
FT   VARIANT         59
FT                   /note="V -> L (in allele DQB1*03:18; dbSNP:rs41563539)"
FT                   /id="VAR_062695"
FT   VARIANT         60
FT                   /note="T -> S (in allele DQB1*02:01, allele DQB1*02:02,
FT                   allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05;
FT                   dbSNP:rs9274405)"
FT                   /id="VAR_062696"
FT   VARIANT         62
FT                   /note="Y -> H (in allele DQB1*05:01, allele DQB1*05:02,
FT                   allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:03,
FT                   allele DQB1*06:04, allele DQB1*06:07, allele DQB1*06:08,
FT                   allele DQB1*06:14, allele DQB1*06:17, allele DQB1*06:21,
FT                   allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28,
FT                   allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32,
FT                   allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and
FT                   allele DQB1*06:39; dbSNP:rs281862065)"
FT                   /id="VAR_062697"
FT   VARIANT         62
FT                   /note="Y -> S (in allele DQB1*02:01, allele DQB1*02:02,
FT                   allele DQB1*02:03, allele DQB1*02:04 and allele
FT                   DQB1*02:05)"
FT                   /id="VAR_062698"
FT   VARIANT         69
FT                   /note="Y -> D (in allele DQB1*06:01 and allele DQB1*06:35;
FT                   dbSNP:rs281874782)"
FT                   /id="VAR_062699"
FT   VARIANT         69
FT                   /note="Y -> I (in allele DQB1*02:01, allele DQB1*02:02,
FT                   allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05;
FT                   requires 2 nucleotide substitutions)"
FT                   /id="VAR_062700"
FT   VARIANT         70
FT                   /note="A -> T (in allele DQB1*03:20; dbSNP:rs45519640)"
FT                   /id="VAR_062701"
FT   VARIANT         70
FT                   /note="A -> V (in allele DQB1*02:01, allele DQB1*02:02,
FT                   allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05,
FT                   allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03,
FT                   allele DQB1*05:04, allele DQB1*06:01, allele DQB1*06:28 and
FT                   allele DQB1*06:35; dbSNP:rs1063318)"
FT                   /id="VAR_062702"
FT   VARIANT         77
FT                   /note="E -> G (in allele DQB1*02:01, allele DQB1*02:02,
FT                   allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05,
FT                   allele DQB1*03:02, allele DQB1*03:03, allele DQB1*03:05,
FT                   allele DQB1*03:06, allele DQB1*03:07, allele DQB1*03:08,
FT                   allele DQB1*03:10, allele DQB1*03:11, allele DQB1*03:12,
FT                   allele DQB1*03:14, allele DQB1*03:15, allele DQB1*03:17,
FT                   allele DQB1*03:18, allele DQB1*03:20, allele DQB1*03:23,
FT                   allele DQB1*03:25, allele DQB1*03:26, allele DQB1*04:01,
FT                   allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:01,
FT                   allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04,
FT                   allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02,
FT                   allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05,
FT                   allele DQB1*06:06, allele DQB1*06:07, allele DQB1*06:08,
FT                   allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11,
FT                   allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14,
FT                   allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17,
FT                   allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20,
FT                   allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23,
FT                   allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27,
FT                   allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30,
FT                   allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33,
FT                   allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:37,
FT                   allele DQB1*06:38 and allele DQB1*06:39; dbSNP:rs1049083)"
FT                   /evidence="ECO:0000269|PubMed:3584986"
FT                   /id="VAR_062703"
FT   VARIANT         78
FT                   /note="V -> E (in allele DQB1*02:01, allele DQB1*02:02,
FT                   allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05;
FT                   dbSNP:rs9274398)"
FT                   /id="VAR_062704"
FT   VARIANT         79
FT                   /note="Y -> F (in allele DQB1*02:01, allele DQB1*02:02,
FT                   allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05;
FT                   dbSNP:rs9274397)"
FT                   /id="VAR_062705"
FT   VARIANT         81
FT                   /note="A -> V (in allele DQB1*03:07; dbSNP:rs41558214)"
FT                   /id="VAR_062706"
FT   VARIANT         84
FT                   /note="P -> L (in allele DQB1*02:01, allele DQB1*02:02,
FT                   allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05;
FT                   dbSNP:rs9274395)"
FT                   /id="VAR_062707"
FT   VARIANT         85
FT                   /note="L -> Q (in allele DQB1*03:23, allele DQB1*05:01,
FT                   allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04,
FT                   allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02,
FT                   allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05,
FT                   allele DQB1*06:06, allele DQB1*06:07, allele DQB1*06:08,
FT                   allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11,
FT                   allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14,
FT                   allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17,
FT                   allele DQB1*06:18, allele DQB1*06:20, allele DQB1*06:22,
FT                   allele DQB1*06:21, allele DQB1*06:23, allele DQB1*06:24,
FT                   allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28,
FT                   allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31,
FT                   allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34,
FT                   allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and
FT                   allele DQB1*06:39; dbSNP:rs1140313)"
FT                   /id="VAR_062708"
FT   VARIANT         87
FT                   /note="P -> L (in allele DQB1*02:01, allele DQB1*02:02,
FT                   allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05;
FT                   dbSNP:rs1130380)"
FT                   /id="VAR_062709"
FT   VARIANT         87
FT                   /note="P -> Q (in allele DQB1*03:16; dbSNP:rs1130380)"
FT                   /id="VAR_062710"
FT   VARIANT         87
FT                   /note="P -> R (in allele DQB1*03:23, allele DQB1*03:25,
FT                   allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03,
FT                   allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03,
FT                   allele DQB1*05:04, allele DQB1*05:05, allele DQB1*06:01,
FT                   allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04,
FT                   allele DQB1*06:05, allele DQB1*06:06, allele DQB1*06:07,
FT                   allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10,
FT                   allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13,
FT                   allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16,
FT                   allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19,
FT                   allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:22,
FT                   allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25,
FT                   allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:30,
FT                   allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33,
FT                   allele DQB1*06:34, allele DQB1*06:35, allele DQB1*06:36,
FT                   allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39;
FT                   dbSNP:rs1130380)"
FT                   /id="VAR_062711"
FT   VARIANT         88
FT                   /note="P -> L (in allele DQB1*03:25, allele DQB1*04:01,
FT                   allele DQB1*04:02 and allele DQB1*04:03; dbSNP:rs1130381)"
FT                   /id="VAR_062712"
FT   VARIANT         89
FT                   /note="D -> A (in allele DQB1*02:01, allele DQB1*02:02,
FT                   allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:02,
FT                   allele DQB1*03:04, allele DQB1*03:05, allele DQB1*03:07,
FT                   allele DQB1*03:08, allele DQB1*03:11, allele DQB1*03:14,
FT                   allele DQB1*03:18 and allele DQB1*06:29; dbSNP:rs1071637)"
FT                   /id="VAR_062713"
FT   VARIANT         89
FT                   /note="D -> S (in allele DQB1*05:02, allele DQB1*05:04,
FT                   allele DQB1*05:05, allele DQB1*06:10 and allele DQB1*06:25;
FT                   requires 2 nucleotide substitutions)"
FT                   /id="VAR_062714"
FT   VARIANT         89
FT                   /note="D -> V (in allele DQB1*05:01, allele DQB1*06:04,
FT                   allele DQB1*06:05, allele DQB1*06:06, allele DQB1*06:08,
FT                   allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:13,
FT                   allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:21,
FT                   allele DQB1*06:22, allele DQB1*06:27, allele DQB1*06:34,
FT                   allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39;
FT                   dbSNP:rs1071637)"
FT                   /id="VAR_062715"
FT   VARIANT         92
FT                   /note="Y -> N (in allele DQB1*06:16; dbSNP:rs41562414)"
FT                   /id="VAR_062716"
FT   VARIANT         94
FT                   /note="N -> K (in allele DQB1*06:37; dbSNP:rs1130382)"
FT                   /id="VAR_062717"
FT   VARIANT         95
FT                   /note="S -> R (in allele DQB1*03:15; dbSNP:rs41556215)"
FT                   /id="VAR_062718"
FT   VARIANT         98
FT                   /note="E -> D (in allele DQB1*02:01, allele DQB1*02:02,
FT                   allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05,
FT                   allele DQB1*03:06, allele DQB1*03:25, allele DQB1*04:01,
FT                   allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:04,
FT                   allele DQB1*06:01 and allele DQB1*06:35; dbSNP:rs9274390)"
FT                   /id="VAR_062719"
FT   VARIANT         99
FT                   /note="V -> D (in allele DQB1*03:13; dbSNP:rs41563814)"
FT                   /id="VAR_062720"
FT   VARIANT         99
FT                   /note="V -> I (in allele DQB1*02:01, allele DQB1*02:02,
FT                   allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05,
FT                   allele DQB1*03:06, allele DQB1*03:25, allele DQB1*04:01,
FT                   allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:04,
FT                   allele DQB1*06:01 and allele DQB1*06:35; dbSNP:rs9274390)"
FT                   /id="VAR_062721"
FT   VARIANT         102
FT                   /note="R -> E (in allele DQB1*03:06, allele DQB1*03:25,
FT                   allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03 and
FT                   allele DQB1*05:04; requires 2 nucleotide substitutions)"
FT                   /id="VAR_062722"
FT   VARIANT         102
FT                   /note="R -> G (in allele DQB1*03:08, allele DQB1*05:01,
FT                   allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05,
FT                   allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:08,
FT                   allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12,
FT                   allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:16,
FT                   allele DQB1*06:17, allele DQB1*06:19, allele DQB1*06:20,
FT                   allele DQB1*06:21, allele DQB1*06:23, allele DQB1*06:24,
FT                   allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30,
FT                   allele DQB1*06:31 and allele DQB1*06:33; dbSNP:rs1130386)"
FT                   /evidence="ECO:0000269|PubMed:3584986"
FT                   /id="VAR_062723"
FT   VARIANT         103
FT                   /note="T -> A (in allele DQB1*05:01, allele DQB1*05:02,
FT                   allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:17,
FT                   allele DQB1*06:24 and allele DQB1*06:30; dbSNP:rs1130390)"
FT                   /id="VAR_062724"
FT   VARIANT         103
FT                   /note="T -> D (in allele DQB1*03:06, allele DQB1*03:25,
FT                   allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03 and
FT                   allele DQB1*05:04; requires 2 nucleotide substitutions)"
FT                   /id="VAR_062725"
FT   VARIANT         103
FT                   /note="T -> K (in allele DQB1*02:01, allele DQB1*02:02,
FT                   allele DQB1*02:03, allele DQB1*02:04 and allele
FT                   DQB1*02:05)"
FT                   /id="VAR_062726"
FT   VARIANT         106
FT                   /note="E -> A (in allele DQB1*02:01, allele DQB1*02:02,
FT                   allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05 and
FT                   allele DQB1*06:06; dbSNP:rs1130387)"
FT                   /id="VAR_062727"
FT   VARIANT         106
FT                   /note="E -> S (in allele DQB1*03:06, allele DQB1*03:25,
FT                   allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03,
FT                   allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03,
FT                   allele DQB1*05:04 and allele DQB1*05:05; requires 2
FT                   nucleotide substitutions)"
FT                   /id="VAR_062728"
FT   VARIANT         107
FT                   /note="L -> V (in allele DQB1*02:01, allele DQB1*02:02,
FT                   allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05,
FT                   allele DQB1*03:06, allele DQB1*03:25, allele DQB1*04:01,
FT                   allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:01,
FT                   allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04,
FT                   allele DQB1*05:05 and allele DQB1*06:06; dbSNP:rs9274384)"
FT                   /id="VAR_062729"
FT   VARIANT         109
FT                   /note="T -> R (in allele DQB1*02:01, allele DQB1*02:02,
FT                   allele DQB1*02:03, allele DQB1*02:04, allele DQB1*05:01,
FT                   allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04,
FT                   allele DQB1*05:05 and allele DQB1*06:06; dbSNP:rs1130392)"
FT                   /id="VAR_062730"
FT   VARIANT         116
FT                   /note="Q -> E (in allele DQB1*05:01, allele DQB1*05:02,
FT                   allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:01,
FT                   allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04,
FT                   allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:08,
FT                   allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11,
FT                   allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14,
FT                   allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17,
FT                   allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20,
FT                   allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23,
FT                   allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27,
FT                   allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30,
FT                   allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33,
FT                   allele DQB1*06:34, allele DQB1*06:35, allele DQB1*06:36,
FT                   allele DQB1*06:37, allele DQB1*06:38, allele DQB1*06:39;
FT                   dbSNP:rs1140316)"
FT                   /id="VAR_062731"
FT   VARIANT         117
FT                   /note="L -> V (in allele DQB1*05:01, allele DQB1*05:02,
FT                   allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:01,
FT                   allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04,
FT                   allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:08,
FT                   allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11,
FT                   allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14,
FT                   allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17,
FT                   allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20,
FT                   allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23,
FT                   allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27,
FT                   allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30,
FT                   allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33,
FT                   allele DQB1*06:34, allele DQB1*06:35, allele DQB1*06:36,
FT                   allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39;
FT                   dbSNP:rs1140317)"
FT                   /id="VAR_062732"
FT   VARIANT         118
FT                   /note="E -> A (in allele DQB1*05:01, allele DQB1*05:02,
FT                   allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:01,
FT                   allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:08,
FT                   allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:13,
FT                   allele DQB1*06:14, allele DQB1*06:16, allele DQB1*06:18,
FT                   allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:23,
FT                   allele DQB1*06:24, allele DQB1*06:27, allele DQB1*06:28,
FT                   allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31,
FT                   allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:35 and
FT                   allele DQB1*06:37; dbSNP:rs9274380)"
FT                   /id="VAR_062733"
FT   VARIANT         118
FT                   /note="E -> G (in allele DQB1*06:04, allele DQB1*06:05,
FT                   allele DQB1*06:07, allele DQB1*06:09, allele DQB1*06:12,
FT                   allele DQB1*06:15, allele DQB1*06:17, allele DQB1*06:21,
FT                   allele DQB1*06:22, allele DQB1*06:25, allele DQB1*06:34,
FT                   allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39;
FT                   dbSNP:rs9274380)"
FT                   /id="VAR_062734"
FT   VARIANT         119
FT                   /note="L -> F (in allele DQB1*06:01, allele DQB1*06:02,
FT                   allele DQB1*06:03, allele DQB1*06:08, allele DQB1*06:10,
FT                   allele DQB1*06:11, allele DQB1*06:13, allele DQB1*06:14,
FT                   allele DQB1*06:16, allele DQB1*06:18, allele DQB1*06:19,
FT                   allele DQB1*06:20, allele DQB1*06:23, allele DQB1*06:24,
FT                   allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29,
FT                   allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32,
FT                   allele DQB1*06:33, allele DQB1*06:35 and allele DQB1*06:37;
FT                   dbSNP:rs9274379)"
FT                   /id="VAR_062735"
FT   VARIANT         119
FT                   /note="L -> Y (in allele DQB1*05:01, allele DQB1*05:02,
FT                   allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:04,
FT                   allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:09,
FT                   allele DQB1*06:12, allele DQB1*06:15, allele DQB1*06:17,
FT                   allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:25,
FT                   allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and
FT                   allele DQB1*06:39; requires 2 nucleotide substitutions)"
FT                   /id="VAR_062736"
FT   VARIANT         121
FT                   /note="T -> G (in allele DQB1*05:01, allele DQB1*05:02,
FT                   allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:01,
FT                   allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04,
FT                   allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:08,
FT                   allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11,
FT                   allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14,
FT                   allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17,
FT                   allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:21,
FT                   allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24,
FT                   allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28,
FT                   allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31,
FT                   allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34,
FT                   allele DQB1*06:35, allele DQB1*06:36, allele DQB1*06:37,
FT                   allele DQB1*06:38 and allele DQB1*06:39; requires 2
FT                   nucleotide substitutions)"
FT                   /id="VAR_062737"
FT   VARIANT         122
FT                   /note="T -> I (in allele DQB1*05:01, allele DQB1*05:02,
FT                   allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:01,
FT                   allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04,
FT                   allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:08,
FT                   allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11,
FT                   allele DQB1*06:12, allele DQB1*06:14, allele DQB1*06:15,
FT                   allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18,
FT                   allele DQB1*06:19, allele DQB1*06:21, allele DQB1*06:22,
FT                   allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25,
FT                   allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29,
FT                   allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32,
FT                   allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:35,
FT                   allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and
FT                   allele DQB1*06:39; dbSNP:rs1140320)"
FT                   /id="VAR_062738"
FT   VARIANT         148
FT                   /note="V -> I (in allele DQB1*05:01, allele DQB1*05:02 and
FT                   allele DQB1*05:03; dbSNP:rs1049100)"
FT                   /id="VAR_056571"
FT   VARIANT         157
FT                   /note="A -> G (in allele DQB1*06:01, allele DQB1*06:02,
FT                   allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09,
FT                   allele DQB1*06:12, allele DQB1*06:34, allele DQB1*06:36,
FT                   allele DQB1*06:38 and allele DQB1*06:39; dbSNP:rs1063322)"
FT                   /id="VAR_062739"
FT   VARIANT         157
FT                   /note="A -> S (in allele DQB1*05:01, allele DQB1*05:02 and
FT                   allele DQB1*05:03)"
FT                   /id="VAR_062740"
FT   VARIANT         158
FT                   /note="Q -> H (in allele DQB1*05:02; dbSNP:rs41542812)"
FT                   /id="VAR_062741"
FT   VARIANT         162
FT                   /note="R -> Q (in allele DQB1*03:22, allele DQB1*06:04,
FT                   allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:34,
FT                   allele DQB1*06:36 and allele DQB1*06:38; dbSNP:rs41544112)"
FT                   /id="VAR_062742"
FT   VARIANT         165
FT                   /note="R -> Q (in allele DQB1*06:38; dbSNP:rs9273989)"
FT                   /id="VAR_062744"
FT   VARIANT         165
FT                   /note="R -> W (in allele DQB1*03:21; dbSNP:rs63626961)"
FT                   /id="VAR_062743"
FT   VARIANT         167
FT                   /note="D -> G (in allele DQB1*02:02; dbSNP:rs2647032)"
FT                   /id="VAR_062745"
FT   VARIANT         168
FT                   /note="Q -> E (in allele DQB1*02:04; dbSNP:rs9273981)"
FT                   /id="VAR_062746"
FT   VARIANT         172
FT                   /note="T -> A (in allele DQB1*02:01, allele DQB1*02:02,
FT                   allele DQB1*02:04, allele DQB1*05:01, allele DQB1*05:02,
FT                   allele DQB1*05:03, allele DQB1*06:01, allele DQB1*06:02,
FT                   allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09,
FT                   allele DQB1*06:12, allele DQB1*06:34, allele DQB1*06:36,
FT                   allele DQB1*06:38 and allele DQB1*06:39; dbSNP:rs1063323)"
FT                   /evidence="ECO:0007744|PubMed:21269460"
FT                   /id="VAR_062747"
FT   VARIANT         194
FT                   /note="E -> D (in dbSNP:rs9273952)"
FT                   /id="VAR_056572"
FT   VARIANT         197
FT                   /note="P -> L (in dbSNP:rs9273948)"
FT                   /id="VAR_059522"
FT   VARIANT         199
FT                   /note="H -> R (in allele DQB1*02:01, allele DQB1*02:02,
FT                   allele DQB1*02:04, allele DQB1*03:02, allele DQB1*03:03,
FT                   allele DQB1*03:05, allele DQB1*03:23, allele DQB1*03:25,
FT                   allele DQB1*04:01, allele DQB1*04:02, allele DQB1*05:01,
FT                   allele DQB1*05:02, allele DQB1*05:03, allele DQB1*06:02,
FT                   allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09,
FT                   allele DQB1*06:12, allele DQB1*06:34, allele DQB1*06:36,
FT                   allele DQB1*06:38 and allele DQB1*06:39; dbSNP:rs701564)"
FT                   /evidence="ECO:0000269|PubMed:3584986"
FT                   /id="VAR_062748"
FT   VARIANT         200..201
FT                   /note="GD -> A (in allele DQB1*03:09)"
FT                   /id="VAR_062749"
FT   VARIANT         202
FT                   /note="V -> I (in allele DQB1*03:24; dbSNP:rs80255621)"
FT                   /id="VAR_062750"
FT   VARIANT         214
FT                   /note="N -> S (in allele DQB1*02:01, allele DQB1*02:02,
FT                   allele DQB1*02:04, allele DQB1*05:01, allele DQB1*05:02,
FT                   allele DQB1*05:03, allele DQB1*06:01, allele DQB1*06:02,
FT                   allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09,
FT                   allele DQB1*06:12, allele DQB1*06:34, allele DQB1*06:36,
FT                   allele DQB1*06:38 and allele DQB1*06:39; dbSNP:rs1130398)"
FT                   /id="VAR_062751"
FT   VARIANT         217
FT                   /note="T -> I (in allele DQB1*03:02, allele DQB1*03:03,
FT                   allele DQB1*03:05, allele DQB1*03:19, allele DQB1*03:25,
FT                   allele DQB1*04:01 and allele DQB1*04:02; dbSNP:rs1130399)"
FT                   /id="VAR_062752"
FT   VARIANT         218
FT                   /note="V -> A (in allele DQB1*06:36; dbSNP:rs281864132)"
FT                   /id="VAR_062753"
FT   VARIANT         229
FT                   /note="S -> N (in allele DQB1*06:01; dbSNP:rs1130429)"
FT                   /id="VAR_062754"
FT   VARIANT         235
FT                   /note="I -> V (in allele DQB1*05:01, allele DQB1*05:02,
FT                   allele DQB1*05:03, allele DQB1*06:02, allele DQB1*06:03,
FT                   allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12 and
FT                   allele DQB1*06:36; dbSNP:rs1049163)"
FT                   /id="VAR_062755"
FT   VARIANT         252
FT                   /note="H -> R (in allele DQB1*05:01, allele DQB1*05:02,
FT                   allele DQB1*05:03, allele DQB1*06:01, allele DQB1*06:02,
FT                   allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09,
FT                   allele DQB1*06:12 and allele DQB1*06:36; dbSNP:rs1140342)"
FT                   /id="VAR_062756"
FT   VARIANT         253
FT                   /note="H -> Q (in allele DQB1*05:01, allele DQB1*05:02,
FT                   allele DQB1*05:03, allele DQB1*06:01, allele DQB1*06:02,
FT                   allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09,
FT                   allele DQB1*06:12 and allele DQB1*06:36; dbSNP:rs1140343)"
FT                   /id="VAR_062757"
FT   VARIANT         256
FT                   /note="Q -> R (in allele DQB1*05:01, allele DQB1*05:02 and
FT                   allele DQB1*05:03; dbSNP:rs1130432)"
FT                   /id="VAR_061474"
FT   CONFLICT        111
FT                   /note="C -> S (in Ref. 71; AAD39697)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        113
FT                   /note="H -> Q (in Ref. 22; AAF28315)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        173
FT                   /note="G -> A (in Ref. 24; X76553/X76554)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        214
FT                   /note="N -> T (in Ref. 8; AAA59770)"
FT                   /evidence="ECO:0000305"
FT   STRAND          40..50
FT                   /evidence="ECO:0007829|PDB:1UVQ"
FT   TURN            51..54
FT                   /evidence="ECO:0007829|PDB:1UVQ"
FT   STRAND          55..64
FT                   /evidence="ECO:0007829|PDB:1UVQ"
FT   STRAND          67..73
FT                   /evidence="ECO:0007829|PDB:1UVQ"
FT   TURN            74..76
FT                   /evidence="ECO:0007829|PDB:1UVQ"
FT   STRAND          78..83
FT                   /evidence="ECO:0007829|PDB:1UVQ"
FT   HELIX           84..86
FT                   /evidence="ECO:0007829|PDB:1UVQ"
FT   HELIX           87..94
FT                   /evidence="ECO:0007829|PDB:1UVQ"
FT   HELIX           97..109
FT                   /evidence="ECO:0007829|PDB:1UVQ"
FT   HELIX           111..117
FT                   /evidence="ECO:0007829|PDB:1UVQ"
FT   HELIX           119..122
FT                   /evidence="ECO:0007829|PDB:1UVQ"
FT   STRAND          130..135
FT                   /evidence="ECO:0007829|PDB:1UVQ"
FT   STRAND          141..144
FT                   /evidence="ECO:0007829|PDB:1JK8"
FT   STRAND          146..157
FT                   /evidence="ECO:0007829|PDB:1UVQ"
FT   STRAND          160..165
FT                   /evidence="ECO:0007829|PDB:1UVQ"
FT   STRAND          168..170
FT                   /evidence="ECO:0007829|PDB:1UVQ"
FT   STRAND          174..176
FT                   /evidence="ECO:0007829|PDB:1UVQ"
FT   STRAND          183..185
FT                   /evidence="ECO:0007829|PDB:1UVQ"
FT   STRAND          187..194
FT                   /evidence="ECO:0007829|PDB:1UVQ"
FT   STRAND          203..208
FT                   /evidence="ECO:0007829|PDB:1UVQ"
FT   STRAND          216..220
FT                   /evidence="ECO:0007829|PDB:1UVQ"
SQ   SEQUENCE   261 AA;  29991 MW;  79B1E571A628CF96 CRC64;
     MSWKKALRIP GGLRAATVTL MLAMLSTPVA EGRDSPEDFV YQFKAMCYFT NGTERVRYVT
     RYIYNREEYA RFDSDVEVYR AVTPLGPPDA EYWNSQKEVL ERTRAELDTV CRHNYQLELR
     TTLQRRVEPT VTISPSRTEA LNHHNLLVCS VTDFYPAQIK VRWFRNDQEE TTGVVSTPLI
     RNGDWTFQIL VMLEMTPQHG DVYTCHVEHP SLQNPITVEW RAQSESAQSK MLSGIGGFVL
     GLIFLGLGLI IHHRSQKGLL H
 
 
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