ID   DQX1_BOVIN              Reviewed;         719 AA.
AC   Q3ZBE0;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=ATP-dependent RNA helicase DQX1;
DE            EC=3.6.4.12;
DE   AltName: Full=DEAQ box polypeptide 1;
GN   Name=DQX1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; BC103411; AAI03412.1; -; mRNA.
DR   RefSeq; NP_001030399.1; NM_001035322.2.
DR   AlphaFoldDB; Q3ZBE0; -.
DR   SMR; Q3ZBE0; -.
DR   STRING; 9913.ENSBTAP00000033112; -.
DR   PaxDb; Q3ZBE0; -.
DR   PRIDE; Q3ZBE0; -.
DR   Ensembl; ENSBTAT00000033191; ENSBTAP00000033112; ENSBTAG00000016609.
DR   GeneID; 517947; -.
DR   KEGG; bta:517947; -.
DR   CTD; 165545; -.
DR   VEuPathDB; HostDB:ENSBTAG00000016609; -.
DR   VGNC; VGNC:28199; DQX1.
DR   eggNOG; KOG0925; Eukaryota.
DR   GeneTree; ENSGT00940000159579; -.
DR   HOGENOM; CLU_001832_5_7_1; -.
DR   InParanoid; Q3ZBE0; -.
DR   OMA; VLYHNFS; -.
DR   OrthoDB; 354219at2759; -.
DR   TreeFam; TF105735; -.
DR   Proteomes; UP000009136; Chromosome 11.
DR   Bgee; ENSBTAG00000016609; Expressed in duodenum and 91 other tissues.
DR   GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF04408; HA2; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00847; HA2; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..719
FT                   /note="ATP-dependent RNA helicase DQX1"
FT                   /id="PRO_0000284376"
FT   DOMAIN          57..225
FT                   /note="Helicase ATP-binding"
FT   DOMAIN          248..449
FT                   /note="Helicase C-terminal"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          694..719
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           170..173
FT                   /note="DEAQ box"
FT   COMPBIAS        703..719
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         70..77
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   719 AA;  79397 MW;  C67101680FBC2B9A CRC64;
     MASQLLGLEE ESGPNPEESE LAVNPFDGLP FSSRYYKLLE QRRSLPVWAA RFIFLEHLES
     SPSGVVLVSG EPGCGKSTQI PQWCAEFVLA RGFQKGWVTV TQPYPLAALS LALRVADEMD
     LTLGHEVGYS IPQEDCTGPD TLLRFCWDRL LLQEVASTRG TGARGVLILD EAQERSVASD
     LLQGLLRDAR LGSLPGDLRV VVVTDPSLEP KLQDFWGGPP TVCVPRKTGS CPTPVYRDSL
     PADRVDAACQ AVLEWCQEEA PGDVLVYLPS EEEISLCCES LSRKVRSLEN QGPPPRVLPL
     HPGCGQAVQA VYEDTESGAR KVVVTHWLAD FSFSLPSIRH VIDSGLELRS VYSPQIRAES
     QVLRPVSKCQ AEARRLRAAG IPPGSCLCLY PKSFLELEAP YLPQPRVWAE NLSSLMLLLK
     RRQIAEPGKC HFLDRPAPEA LMQALEDLDY LAALDDDGDL SDLGVILSEF PLAPELAKAL
     LASCEFDCVD EMLTLAAMLT AAPGFTRPPV CAEEAALRRA LEHVDGDHSS LIQVYEAFIQ
     SGADKAWCQA RGLNWAALCQ ARKLRGELLE LMQRIELPLS QPAFGSERNR RDLQKALVSG
     YFLKVARDTD GTGNYLLLTH KHVAQLSPNC CYRSRRAPAR PPLWVLYHSF SISKDNCLSI
     VSEIQPQMLV ELAPPYFLSN LPPSESRDFL NQLREERTDS SIRSESSSTQ ELENACALQ