DQX1_MOUSE
ID DQX1_MOUSE Reviewed; 718 AA.
AC Q924H9; Q80ZJ5;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=ATP-dependent RNA helicase DQX1;
DE EC=3.6.4.12;
DE AltName: Full=DEAQ box polypeptide 1;
GN Name=Dqx1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J;
RX PubMed=11353393; DOI=10.1007/s003350020032;
RA Ji W., Chen F., Do T., Do A., Roe B.A., Meisler M.H.;
RT "DQX1, an RNA-dependent ATPase homolog with a novel DEAQ box: expression
RT pattern and genomic sequence comparison of the human and mouse genes.";
RL Mamm. Genome 12:456-461(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Colon, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q924H9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q924H9-2; Sequence=VSP_024473;
CC -!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:11353393}.
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DR EMBL; AF318278; AAK62817.1; -; mRNA.
DR EMBL; BC048936; AAH48936.1; -; mRNA.
DR EMBL; BC075680; AAH75680.1; -; mRNA.
DR CCDS; CCDS20268.1; -. [Q924H9-1]
DR RefSeq; NP_291084.1; NM_033606.3. [Q924H9-1]
DR RefSeq; XP_006506870.1; XM_006506807.3. [Q924H9-1]
DR RefSeq; XP_006506871.1; XM_006506808.3. [Q924H9-1]
DR RefSeq; XP_006506872.1; XM_006506809.1. [Q924H9-1]
DR AlphaFoldDB; Q924H9; -.
DR SMR; Q924H9; -.
DR STRING; 10090.ENSMUSP00000076708; -.
DR PhosphoSitePlus; Q924H9; -.
DR MaxQB; Q924H9; -.
DR PaxDb; Q924H9; -.
DR PeptideAtlas; Q924H9; -.
DR PRIDE; Q924H9; -.
DR ProteomicsDB; 277402; -. [Q924H9-1]
DR ProteomicsDB; 277403; -. [Q924H9-2]
DR Antibodypedia; 47481; 133 antibodies from 25 providers.
DR Ensembl; ENSMUST00000077502; ENSMUSP00000076708; ENSMUSG00000009145. [Q924H9-1]
DR GeneID; 93838; -.
DR KEGG; mmu:93838; -.
DR UCSC; uc009cmc.1; mouse. [Q924H9-1]
DR UCSC; uc009cmd.1; mouse. [Q924H9-2]
DR CTD; 165545; -.
DR MGI; MGI:2136388; Dqx1.
DR VEuPathDB; HostDB:ENSMUSG00000009145; -.
DR eggNOG; KOG0925; Eukaryota.
DR GeneTree; ENSGT00940000159579; -.
DR HOGENOM; CLU_001832_5_7_1; -.
DR InParanoid; Q924H9; -.
DR OMA; VLYHNFS; -.
DR OrthoDB; 354219at2759; -.
DR PhylomeDB; Q924H9; -.
DR TreeFam; TF105735; -.
DR BioGRID-ORCS; 93838; 2 hits in 74 CRISPR screens.
DR ChiTaRS; Dqx1; mouse.
DR PRO; PR:Q924H9; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q924H9; protein.
DR Bgee; ENSMUSG00000009145; Expressed in small intestine Peyer's patch and 64 other tissues.
DR ExpressionAtlas; Q924H9; baseline and differential.
DR Genevisible; Q924H9; MM.
DR GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; ISA:MGI.
DR GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF04408; HA2; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; ATP-binding; Helicase; Hydrolase; Nucleotide-binding;
KW Nucleus; Reference proteome.
FT CHAIN 1..718
FT /note="ATP-dependent RNA helicase DQX1"
FT /id="PRO_0000284378"
FT DOMAIN 54..222
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT DOMAIN 245..447
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT REGION 690..718
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 167..170
FT /note="DEAQ box"
FT BINDING 67..74
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT VAR_SEQ 1..417
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_024473"
SQ SEQUENCE 718 AA; 78799 MW; 4285388B61D69EB4 CRC64;
MASGLAEESE LSPGESELAV NPFDGLPFSS CYYELLEQRR ALPIWAARFL FLEHLESSPT
GVVLVSGDPG SGKSTQIPQW CAEFALARGF QTGQVTVTQP YPLAAMSLAS RVADEMDLTL
GHEIGYSIPQ EDCTGPNTML RFCWDRLFLQ EVASTRGPGA WSVLILDEAQ ERSVASDLLQ
GLLRDTRLRN LPGDPRVVVV TDPALEPKFQ AFWGNSPIVR VPREPGGDPT LAYKDTVPTD
LVEAACQAVL ELCQQEEAPG DVLVYLPSEE EISLCCESLS GEMGTLAVPG PPPRVLPLHP
GCAQAIQTVY EDTDVSVRKI VVTHWLADFS FSLPSIQHVI DSGLELRSVY NPRIRAESQV
LRPISKCQAE ARLLRAKGFP PGSCLRLYSK STLELEAPPL PHPKVCEENL SSLVLLLMRK
QIAEPGECHF LDRPAPEALM RALEDLDYLA ALNDDGELSD LGVILSEFPL PPELAKALLA
SCEFNCVDEM LTLAAMLTAA PGFTRPPLSA GEAALRRALE HADGDHSSLI QVYEAFVQSG
ADEAWCQARG LNWESLCQAR KLRAELVELM QRIELPLSQP AFGSEQNRRD LQKALLSGYF
LKVARDTDGT GNYLLLTHKH VAQLSPYCSY RNRRTPAQPP TWVLYHSFSI SKDNCLCIVS
EIQPEMLVEL APPYFLSNLP PSESRDLLNQ LREGTAEPPA AATETSSPQE YGDGCVLQ
