DR100_ARATH
ID DR100_ARATH Reviewed; 372 AA.
AC Q00874; Q9LHK0;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2002, sequence version 2.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=DNA damage-repair/toleration protein DRT100;
DE Flags: Precursor;
GN Name=DRT100; OrderedLocusNames=At3g12610;
GN ORFNames=MMF12.5, T2E22.8, T2E22_107;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP PRELIMINARY NUCLEOTIDE SEQUENCE OF 4-372.
RC STRAIN=cv. Columbia;
RX PubMed=1518832; DOI=10.1073/pnas.89.17.8073;
RA Pang Q., Hays J.B., Rajagopal I.;
RT "A plant cDNA that partially complements Escherichia coli recA mutations
RT predicts a polypeptide not strongly homologous to RecA proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 89:8073-8077(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT clones.";
RL DNA Res. 7:217-221(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is able to complement bacterial recA mutations,
CC but its native function in the plant is not known.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA47109.2; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; X66482; CAA47109.2; ALT_FRAME; mRNA.
DR EMBL; AP002044; BAB02252.1; -; Genomic_DNA.
DR EMBL; AC069474; AAG51016.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE75223.1; -; Genomic_DNA.
DR EMBL; BT000814; AAN33189.1; -; mRNA.
DR EMBL; AY057652; AAL15283.1; -; mRNA.
DR EMBL; AY086931; AAM64495.1; -; mRNA.
DR PIR; A46260; A46260.
DR RefSeq; NP_187867.1; NM_112096.3.
DR AlphaFoldDB; Q00874; -.
DR SMR; Q00874; -.
DR STRING; 3702.AT3G12610.1; -.
DR PaxDb; Q00874; -.
DR PRIDE; Q00874; -.
DR ProteomicsDB; 241254; -.
DR EnsemblPlants; AT3G12610.1; AT3G12610.1; AT3G12610.
DR GeneID; 820441; -.
DR Gramene; AT3G12610.1; AT3G12610.1; AT3G12610.
DR KEGG; ath:AT3G12610; -.
DR Araport; AT3G12610; -.
DR TAIR; locus:2091260; AT3G12610.
DR eggNOG; KOG0619; Eukaryota.
DR HOGENOM; CLU_000288_18_22_1; -.
DR InParanoid; Q00874; -.
DR OMA; FRSCKSP; -.
DR OrthoDB; 826997at2759; -.
DR PhylomeDB; Q00874; -.
DR PRO; PR:Q00874; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q00874; baseline and differential.
DR Genevisible; Q00874; AT.
DR GO; GO:0009507; C:chloroplast; ISS:TAIR.
DR GO; GO:0000166; F:nucleotide binding; ISS:TAIR.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR013210; LRR_N_plant-typ.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13516; LRR_6; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF08263; LRRNT_2; 1.
PE 2: Evidence at transcript level;
KW DNA damage; DNA repair; Leucine-rich repeat; Reference proteome; Repeat;
KW Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..372
FT /note="DNA damage-repair/toleration protein DRT100"
FT /id="PRO_0000021118"
FT REPEAT 136..158
FT /note="LRR 1"
FT REPEAT 160..183
FT /note="LRR 2"
FT REPEAT 184..205
FT /note="LRR 3"
FT REPEAT 208..230
FT /note="LRR 4"
FT REPEAT 232..254
FT /note="LRR 5"
FT REPEAT 256..277
FT /note="LRR 6"
FT REPEAT 280..302
FT /note="LRR 7"
FT REPEAT 304..326
FT /note="LRR 8"
FT REPEAT 328..350
FT /note="LRR 9"
SQ SEQUENCE 372 AA; 39556 MW; BA4361101AC45659 CRC64;
MRKLLASPFS SLLAVVFISV ISVVRCCSPK DQTALNAFKS SLSEPNLGIF NTWSENTDCC
KEWYGISCDP DSGRVTDISL RGESEDAIFQ KAGRSGYMSG SIDPAVCDLT ALTSLVLADW
KGITGEIPPC ITSLASLRIL DLAGNKITGE IPAEIGKLSK LAVLNLAENQ MSGEIPASLT
SLIELKHLEL TENGITGVIP ADFGSLKMLS RVLLGRNELT GSIPESISGM ERLADLDLSK
NHIEGPIPEW MGNMKVLSLL NLDCNSLTGP IPGSLLSNSG LDVANLSRNA LEGTIPDVFG
SKTYLVSLDL SHNSLSGRIP DSLSSAKFVG HLDISHNKLC GRIPTGFPFD HLEATSFSDN
QCLCGGPLTT SC
