ID   DR206_PEA               Reviewed;         184 AA.
AC   P13240;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 2.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Disease resistance response protein 206;
DE   AltName: Full=Dirigent protein PI206;
DE   Flags: Precursor;
GN   Name=PI206;
OS   Pisum sativum (Garden pea).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   NPAAA clade; Hologalegina; IRL clade; Fabeae; Pisum.
OX   NCBI_TaxID=3888;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=cv. Alcan;
RX   PubMed=7870833; DOI=10.1104/pp.107.1.301;
RA   Culley D.E., Horovitz D., Hadwiger L.A.;
RT   "Molecular characterization of disease-resistance response gene DRR206-d
RT   from Pisum sativum (L.).";
RL   Plant Physiol. 107:301-302(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 10-184.
RC   STRAIN=cv. Alaska;
RX   AGRICOLA=IND92000015; DOI=10.1007/BF00017470;
RA   Fristensky B.W., Horovitz D., Hadwiger L.A.;
RT   "cDNA sequences for pea disease resistance response genes.";
RL   Plant Mol. Biol. 11:713-715(1988).
CC   -!- FUNCTION: Dirigent proteins impart stereoselectivity on the phenoxy
CC       radical-coupling reaction, yielding optically active lignans from two
CC       molecules of coniferyl alcohol in the biosynthesis of lignans,
CC       flavonolignans, and alkaloids and thus plays a central role in plant
CC       secondary metabolism. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, apoplast
CC       {ECO:0000250}.
CC   -!- INDUCTION: Upon contact with the plant pathogens fungus Fusarium
CC       solani, Pseudomonas syringae pv pisi, and the fungal elicitor chitosan.
CC   -!- SIMILARITY: Belongs to the plant dirigent protein family.
CC       {ECO:0000305}.
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DR   EMBL; U11716; AAB18669.1; -; Unassigned_DNA.
DR   EMBL; M18250; AAA33662.1; -; mRNA.
DR   PIR; T06433; T06433.
DR   PDB; 4REV; X-ray; 1.95 A; A/B=21-184.
DR   PDBsum; 4REV; -.
DR   AlphaFoldDB; P13240; -.
DR   SMR; P13240; -.
DR   GO; GO:0048046; C:apoplast; IEA:UniProtKB-SubCell.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0009699; P:phenylpropanoid biosynthetic process; IEA:UniProt.
DR   GO; GO:0009607; P:response to biotic stimulus; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.480.10; -; 1.
DR   InterPro; IPR044859; Allene_oxi_cyc_Dirigent.
DR   InterPro; IPR004265; Dirigent.
DR   PANTHER; PTHR46442; PTHR46442; 1.
DR   Pfam; PF03018; Dirigent; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Apoplast; Disulfide bond; Glycoprotein;
KW   Pathogenesis-related protein; Plant defense; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..184
FT                   /note="Disease resistance response protein 206"
FT                   /id="PRO_0000080000"
FT   CARBOHYD        50
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        120
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        31..183
FT                   /evidence="ECO:0000250"
FT   STRAND          31..41
FT                   /evidence="ECO:0007829|PDB:4REV"
FT   STRAND          75..88
FT                   /evidence="ECO:0007829|PDB:4REV"
FT   STRAND          93..103
FT                   /evidence="ECO:0007829|PDB:4REV"
FT   STRAND          112..123
FT                   /evidence="ECO:0007829|PDB:4REV"
FT   STRAND          125..133
FT                   /evidence="ECO:0007829|PDB:4REV"
FT   STRAND          140..150
FT                   /evidence="ECO:0007829|PDB:4REV"
FT   TURN            151..154
FT                   /evidence="ECO:0007829|PDB:4REV"
FT   STRAND          156..166
FT                   /evidence="ECO:0007829|PDB:4REV"
FT   STRAND          171..182
FT                   /evidence="ECO:0007829|PDB:4REV"
SQ   SEQUENCE   184 AA;  20371 MW;  74D69009356DA343 CRC64;
     MGSKLLVLFV FVMLFALSSA IPNKRKPYKP CKNLVFYFHD ILYNGKNAAN ATSAIVAAPE
     GVSLTKLAPQ SHFGNIIVFD DPITLSHSLS SKQVGRAQGF YIYDTKNTYT SWLSFTFVLN
     STHHQGTITF AGADPIVAKT RDISVTGGTG DFFMHRGIAT ITTDAFEGEA YFRLGVYIKF
     FECW