DR4L1_HUMAN
ID DR4L1_HUMAN Reviewed; 281 AA.
AC P0CG22;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 15-JUN-2010, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=Putative dehydrogenase/reductase SDR family member 4-like 1;
DE EC=1.1.-.-;
DE AltName: Full=Short chain dehydrogenase/reductase family 25C member 4 {ECO:0000303|PubMed:19027726};
DE Short=Protein SDR25C4 {ECO:0000303|PubMed:19027726};
GN Name=DHRS4L1 {ECO:0000312|HGNC:HGNC:19732};
GN Synonyms=SDR25C4 {ECO:0000303|PubMed:19027726};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [2]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=19027726; DOI=10.1016/j.cbi.2008.10.040;
RA Persson B., Kallberg Y., Bray J.E., Bruford E., Dellaporta S.L.,
RA Favia A.D., Duarte R.G., Joernvall H., Kavanagh K.L., Kedishvili N.,
RA Kisiela M., Maser E., Mindnich R., Orchard S., Penning T.M., Thornton J.M.,
RA Adamski J., Oppermann U.;
RT "The SDR (short-chain dehydrogenase/reductase and related enzymes)
RT nomenclature initiative.";
RL Chem. Biol. Interact. 178:94-98(2009).
RN [3]
RP MISCELLANEOUS.
RX PubMed=27323117; DOI=10.4238/gmr.15027752;
RA Su Z., Liu G., Song X., Liang B., Chang X., Huang D.;
RT "CpG island evolution in the mammalian DHRS4 gene cluster and its role in
RT the regulation of gene transcription.";
RL Genet. Mol. Res. 15:0-0(2016).
CC -!- FUNCTION: Putative oxidoreductase. {ECO:0000250}.
CC -!- MISCELLANEOUS: Three homologous proteins DHRS4, DHRS4L1, and DHRS4L2
CC are derived from gene duplication of DHRS4, and the gene cluster is
CC arranged in tandem in chromosome 14. {ECO:0000269|PubMed:27323117}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000305}.
CC -!- CAUTION: Product of a dubious CDS prediction. {ECO:0000305}.
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DR EMBL; AL136295; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; P0CG22; -.
DR SMR; P0CG22; -.
DR DrugBank; DB03541; 10-Propargyl-5,8-Dideazafolic Acid.
DR DrugBank; DB02532; 2,4,6-Triaminoquinazoline.
DR DrugBank; DB07765; METHYL 1-(4-{[(2,4-DIAMINOPTERIDIN-6-YL)METHYL](METHYL)AMINO}BENZOYL)PIPERIDINE-4-CARBOXYLATE.
DR DrugBank; DB07689; METHYL 1-(4-{[(2,4-DIAMINOPTERIDIN-6-YL)METHYL]AMINO}BENZOYL)PIPERIDINE-4-CARBOXYLATE.
DR DrugBank; DB03461; Nicotinamide adenine dinucleotide phosphate.
DR iPTMnet; P0CG22; -.
DR PhosphoSitePlus; P0CG22; -.
DR BioMuta; HGNC:19732; -.
DR DMDM; 298351658; -.
DR jPOST; P0CG22; -.
DR MassIVE; P0CG22; -.
DR MaxQB; P0CG22; -.
DR PeptideAtlas; P0CG22; -.
DR PRIDE; P0CG22; -.
DR ProteomicsDB; 52456; -.
DR GeneCards; DHRS4L1; -.
DR HGNC; HGNC:19732; DHRS4L1.
DR MIM; 615195; gene.
DR neXtProt; NX_P0CG22; -.
DR PharmGKB; PA134878665; -.
DR InParanoid; P0CG22; -.
DR PhylomeDB; P0CG22; -.
DR PathwayCommons; P0CG22; -.
DR ChiTaRS; DHRS4L1; human.
DR Pharos; P0CG22; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; P0CG22; protein.
DR GO; GO:0005777; C:peroxisome; IBA:GO_Central.
DR GO; GO:0004090; F:carbonyl reductase (NADPH) activity; IBA:GO_Central.
DR GO; GO:0042574; P:retinal metabolic process; IBA:GO_Central.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR PRINTS; PR00081; GDHRDH.
DR SUPFAM; SSF51735; SSF51735; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 5: Uncertain;
KW NAD; NADP; Oxidoreductase; Reference proteome.
FT CHAIN 1..281
FT /note="Putative dehydrogenase/reductase SDR family member
FT 4-like 1"
FT /id="PRO_0000395063"
FT MOTIF 279..281
FT /note="Peroxisomal targeting signal"
FT /evidence="ECO:0000250|UniProtKB:Q8WNV7"
FT ACT_SITE 185
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT BINDING 36..60
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250|UniProtKB:Q8WNV7"
FT BINDING 172
FT /ligand="substrate"
FT /evidence="ECO:0000250|UniProtKB:Q99714"
FT BINDING 189
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250|UniProtKB:Q8WNV7"
SQ SEQUENCE 281 AA; 30608 MW; EC8FFF8B6145FA18 CRC64;
MHKARLRGHC ARAGKSVRLA SSGMTRRDPL TNKVALVTAS TDWIGFAVAQ RLAQDGAHVV
VSRRKQQNVD QAVATLQGEG LSMTGTVCHV GKMKDWERLV ATAMKLHGVI DILSLSITNS
KRGLFWFTLL QTAEEAWDRN LDINGKALAL MIKAVVPEME KRGGGSVGFL ASVAAFRPLP
GFSPYNVSKT ALLGLNKTLA IELAPRNIRV NCLAPGLIKT SFSRMLWMDK EKEESMKETL
RIRRLGEPED SLGIVSFLCS EDASYLTGET VMVGGGTPSR L
