ID   DR7_HHV6U               Reviewed;         363 AA.
AC   Q89743; Q69578;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   29-SEP-2021, entry version 61.
DE   RecName: Full=Uncharacterized protein DR7;
GN   Name=DR7L;
GN   and
GN   Name=DR7R;
OS   Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B
OS   lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=10370;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8134119;
RA   Thompson J., Choudhury S., Kashanchi F., Doniger J., Berneman Z.,
RA   Frenkel N., Rosenthal L.J.;
RT   "A transforming fragment within the direct repeat region of human
RT   herpesvirus type 6 that transactivates HIV-1.";
RL   Oncogene 9:1167-1175(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=7747482; DOI=10.1006/viro.1995.1228;
RA   Gompels U.A., Nicholas J., Lawrence G.L., Jones M., Thomson B.J.,
RA   Martin M.E.D., Efstathiou S., Craxton M.A., Macaulay H.A.;
RT   "The DNA sequence of human herpesvirus-6: structure, coding content, and
RT   genome evolution.";
RL   Virology 209:29-51(1995).
RN   [3]
RP   FUNCTION.
RX   PubMed=8178493; DOI=10.1006/viro.1994.1269;
RA   Kashanchi F., Thompson J., Sadaie M.R., Doniger J., Duvall J., Brady J.N.,
RA   Rosenthal L.J.;
RT   "Transcriptional activation of minimal HIV-1 promoter by ORF-1 protein
RT   expressed from the SalI-L fragment of human herpesvirus 6.";
RL   Virology 201:95-106(1994).
RN   [4]
RP   FUNCTION, AND INTERACTION WITH HUMAN P53.
RX   PubMed=9018122; DOI=10.1038/sj.onc.1200840;
RA   Kashanchi F., Araujo J., Doniger J., Muralidhar S., Hoch R., Khleif S.,
RA   Mendelson E., Thompson J., Azumi N., Brady J.N., Luppi M., Torelli G.,
RA   Rosenthal L.J.;
RT   "Human herpesvirus 6 (HHV-6) ORF-1 transactivating gene exhibits malignant
RT   transforming activity and its protein binds to p53.";
RL   Oncogene 14:359-367(1997).
CC   -!- FUNCTION: Involved in transactivation (Probable). Displays transforming
CC       activity. {ECO:0000269|PubMed:8178493, ECO:0000269|PubMed:9018122,
CC       ECO:0000305}.
CC   -!- SUBUNIT: Interacts with human p53 and inhibits p53-activated
CC       transcription. {ECO:0000269|PubMed:9018122}.
CC   -!- SIMILARITY: Belongs to the herpesviridae US22 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA52024.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; X73675; CAA52024.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; X83413; CAA58327.1; -; Genomic_DNA.
DR   EMBL; X83413; CAA58425.1; -; Genomic_DNA.
DR   PIR; S43067; S43067.
DR   PRIDE; Q89743; -.
DR   Proteomes; UP000009295; Genome.
DR   InterPro; IPR003360; US22-like.
DR   Pfam; PF02393; US22; 1.
PE   1: Evidence at protein level;
KW   Activator; Host-virus interaction; Oncogene; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..363
FT                   /note="Uncharacterized protein DR7"
FT                   /id="PRO_0000342567"
SQ   SEQUENCE   363 AA;  40830 MW;  E665E1E8A3C4B714 CRC64;
     MRHLPFHGMP LRVQMFCAFF IRSETTDKNK ATPTITFMVS CCFVWVKRLF YRVGRIHHVQ
     SLTYARPITA LDSCLYVCCG YGEKLQPVGF VKSYVTNSQL DTLRVLLVGK DGAVYVHHMR
     AARLCRLASS TTEFTRRGLQ RDAVTYEEDL ELPDQRMCGT NARHLFDVIA AAADEHNLLT
     VGGLCQTHAG VSCNLLETVG DPWTAVPAAR MTLTVPQVQY RLWPEARRDL RRHLYAGHPL
     GPWLVCGVLS RERETQKPSP PIRTTVGNVP TPGPREVEIA WVVLTLAGPL LAFWPDTGKI
     CRLANSFSTL WKMGPRAMRG HWTYSAPGRH LPGDAWPLCE HVRPQWKASE EESVPGLDAT
     EVK