DR9C7_BOVIN
ID DR9C7_BOVIN Reviewed; 313 AA.
AC A4IFM3;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Short-chain dehydrogenase/reductase family 9C member 7;
DE EC=1.1.1.-;
DE AltName: Full=Orphan short-chain dehydrogenase/reductase;
DE Short=SDR-O;
GN Name=SDR9C7; Synonyms=RDHS, SDRO;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal skin;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Displays weak conversion of all-trans-retinal to all-trans-
CC retinol in the presence of NADH. Has apparently no steroid
CC dehydrogenase activity (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000305}.
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DR EMBL; BC134658; AAI34659.1; -; mRNA.
DR RefSeq; NP_001077206.1; NM_001083737.1.
DR AlphaFoldDB; A4IFM3; -.
DR SMR; A4IFM3; -.
DR STRING; 9913.ENSBTAP00000017885; -.
DR PaxDb; A4IFM3; -.
DR Ensembl; ENSBTAT00000017885; ENSBTAP00000017885; ENSBTAG00000013443.
DR GeneID; 538876; -.
DR KEGG; bta:538876; -.
DR CTD; 121214; -.
DR VEuPathDB; HostDB:ENSBTAG00000013443; -.
DR VGNC; VGNC:34398; SDR9C7.
DR eggNOG; KOG1610; Eukaryota.
DR GeneTree; ENSGT00940000161764; -.
DR HOGENOM; CLU_010194_2_0_1; -.
DR InParanoid; A4IFM3; -.
DR OMA; IRRELHF; -.
DR OrthoDB; 942985at2759; -.
DR TreeFam; TF325617; -.
DR Reactome; R-BTA-2453902; The canonical retinoid cycle in rods (twilight vision).
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000013443; Expressed in zone of skin and 13 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0004745; F:NAD-retinol dehydrogenase activity; IBA:GO_Central.
DR GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR GO; GO:0016229; F:steroid dehydrogenase activity; IBA:GO_Central.
DR GO; GO:0042572; P:retinol metabolic process; IBA:GO_Central.
DR GO; GO:0008202; P:steroid metabolic process; IBA:GO_Central.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR032968; SDR_9C7.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR43313:SF5; PTHR43313:SF5; 1.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; SSF51735; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; NADP; Oxidoreductase; Phosphoprotein; Reference proteome.
FT CHAIN 1..313
FT /note="Short-chain dehydrogenase/reductase family 9C member
FT 7"
FT /id="PRO_0000316884"
FT ACT_SITE 172
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT BINDING 29..53
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250"
FT BINDING 160
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT MOD_RES 185
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8NEX9"
SQ SEQUENCE 313 AA; 35191 MW; 3DA249F9EECDAEFB CRC64;
MAAISDLSFM YRWFKNCNLV RNLSDKYVFI TGCDSGFGNL LARQLVDRGM RVLAACFTKE
GAQKLQQDTS YQLQTILLDV TKTESIKAAT QWVRDQVGEQ GLWALVNNAG VGLPSGPNEW
LTKEDFVKVI NVNLVGLIEV TLHMLPMVKK ARGRVVNMSS SGGRVAVIGG GYCISKFGVE
AFSDSIRREL HYFGVKVSII EPGNFRTAIL GKDGLEKHMR KLWERLPPET RESYGEEYFR
IYTDNLKSTM QLADPRISEV TNSMEHAIVS RSPRIRYNPG LDAKLLYLPL AKFPTPVTDF
ILSRYLPRPA DSV
