ID   DRAM1_XENLA             Reviewed;         239 AA.
AC   Q6NRS6;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 2.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=DNA damage-regulated autophagy modulator protein 1;
DE   AltName: Full=Damage-regulated autophagy modulator;
GN   Name=dram1; Synonyms=dram;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Lysosomal modulator of autophagy that plays a central role in
CC       p53/TP53-mediated apoptosis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DRAM/TMEM150 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH70646.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC070646; AAH70646.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; Q6NRS6; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   InterPro; IPR019402; Frag1/DRAM/Sfk1.
DR   Pfam; PF10277; Frag1; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Autophagy; Lysosome; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..239
FT                   /note="DNA damage-regulated autophagy modulator protein 1"
FT                   /id="PRO_0000287438"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        54..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   239 AA;  26622 MW;  EE851D32154FF09D CRC64;
     MHCWCLQGAA FLPSILVIWS SAGFLFSYII SVLIGHVPPF VPYISDTGTS PPESGVFGFM
     ISVSAMLGAA TMYTRYMILE RQNLSIDFLP IYFNKISLAI GLFGCIGMGI VATFQEMAVP
     AVHDAGALIT FICGVMYILL QSYISYKSCP TWNTRATCHI RMTVSLIAFI AVVPMSVFSI
     LSGRKRLDWK PSDEGYPYHL TSAICEWTVA FGFNMYFLTF IRDFQGVSIQ ISTEIHEDF