ID   DRAM1_XENTR             Reviewed;         239 AA.
AC   Q5EAK8;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=DNA damage-regulated autophagy modulator protein 1;
DE   AltName: Full=Damage-regulated autophagy modulator;
GN   Name=dram1; Synonyms=dram;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Lysosomal modulator of autophagy that plays a central role in
CC       p53/TP53-mediated apoptosis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DRAM/TMEM150 family. {ECO:0000305}.
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DR   EMBL; BC090386; AAH90386.1; -; mRNA.
DR   RefSeq; NP_001015869.1; NM_001015869.1.
DR   AlphaFoldDB; Q5EAK8; -.
DR   STRING; 8364.ENSXETP00000009867; -.
DR   PaxDb; Q5EAK8; -.
DR   DNASU; 548586; -.
DR   Ensembl; ENSXETT00000009867; ENSXETP00000009867; ENSXETG00000027990.
DR   GeneID; 548586; -.
DR   KEGG; xtr:548586; -.
DR   CTD; 55332; -.
DR   Xenbase; XB-GENE-489272; dram1.
DR   eggNOG; KOG4320; Eukaryota.
DR   HOGENOM; CLU_059992_2_2_1; -.
DR   InParanoid; Q5EAK8; -.
DR   OMA; MTFISSC; -.
DR   OrthoDB; 1199230at2759; -.
DR   TreeFam; TF314508; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000027990; Expressed in heart and 10 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005764; C:lysosome; IBA:GO_Central.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0010506; P:regulation of autophagy; IBA:GO_Central.
DR   InterPro; IPR019402; Frag1/DRAM/Sfk1.
DR   Pfam; PF10277; Frag1; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Autophagy; Lysosome; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..239
FT                   /note="DNA damage-regulated autophagy modulator protein 1"
FT                   /id="PRO_0000287439"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        54..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   239 AA;  26578 MW;  2504EC8C84A34DA8 CRC64;
     MPCWCLHGAA FLPSILVIWS SAGFLFSYII SVLIGHVPPF VPYISDTGTS PPESGVFGFM
     ISLSAMLGAA TMYTRYKILE KQNHSTDFLP YYFNKTSLAI GLLGCIGMGI VATFQEMAVP
     AVHDAGALIT FICGVLYILL QSYISYKSCP AWNTRVTCHI RMAISVIAFI AVVPMSVFSV
     LSGRKRLDWK PSDEGYHYHL TSAICEWIVA FGFNMYFLTF IRDFQGVSIQ ISTEIHEDF