ID   DRAM2_BOVIN             Reviewed;         266 AA.
AC   Q3ZC48;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=DNA damage-regulated autophagy modulator protein 2;
DE   AltName: Full=Transmembrane protein 77;
GN   Name=DRAM2; Synonyms=TMEM77;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in the initiation of autophagy. In the retina,
CC       might be involved in the process of photoreceptor cells renewal and
CC       recycling to preserve visual function. Induces apoptotic cell death
CC       when coexpressed with DRAM1. {ECO:0000250|UniProtKB:Q6UX65}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q6UX65};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:Q6UX65}.
CC       Photoreceptor inner segment {ECO:0000250|UniProtKB:Q9CR48}. Apical cell
CC       membrane {ECO:0000250|UniProtKB:Q9CR48}. Note=Localized to
CC       photoreceptor inner segments and to the apical surface of retinal
CC       pigment epithelial cells. {ECO:0000250|UniProtKB:Q9CR48}.
CC   -!- SIMILARITY: Belongs to the DRAM/TMEM150 family. {ECO:0000305}.
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DR   EMBL; BC102918; AAI02919.1; -; mRNA.
DR   RefSeq; NP_001070464.1; NM_001076996.2.
DR   RefSeq; XP_010801534.1; XM_010803232.2.
DR   RefSeq; XP_015319466.1; XM_015463980.1.
DR   AlphaFoldDB; Q3ZC48; -.
DR   SMR; Q3ZC48; -.
DR   STRING; 9913.ENSBTAP00000013037; -.
DR   PaxDb; Q3ZC48; -.
DR   Ensembl; ENSBTAT00000013037; ENSBTAP00000013037; ENSBTAG00000009888.
DR   Ensembl; ENSBTAT00000070934; ENSBTAP00000071255; ENSBTAG00000009888.
DR   GeneID; 767922; -.
DR   KEGG; bta:767922; -.
DR   CTD; 128338; -.
DR   VEuPathDB; HostDB:ENSBTAG00000009888; -.
DR   VGNC; VGNC:28202; DRAM2.
DR   eggNOG; KOG4320; Eukaryota.
DR   GeneTree; ENSGT01030000234578; -.
DR   HOGENOM; CLU_059992_2_2_1; -.
DR   InParanoid; Q3ZC48; -.
DR   OMA; IYMLVQT; -.
DR   OrthoDB; 1199230at2759; -.
DR   TreeFam; TF314508; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000009888; Expressed in conceptus and 109 other tissues.
DR   GO; GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005764; C:lysosome; ISS:UniProtKB.
DR   GO; GO:0001917; C:photoreceptor inner segment; ISS:UniProtKB.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0045494; P:photoreceptor cell maintenance; ISS:UniProtKB.
DR   GO; GO:0010506; P:regulation of autophagy; IBA:GO_Central.
DR   GO; GO:0007601; P:visual perception; ISS:UniProtKB.
DR   InterPro; IPR032990; DRAM2.
DR   InterPro; IPR019402; Frag1/DRAM/Sfk1.
DR   PANTHER; PTHR21324:SF10; PTHR21324:SF10; 1.
DR   Pfam; PF10277; Frag1; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Autophagy; Cell membrane; Lysosome; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..266
FT                   /note="DNA damage-regulated autophagy modulator protein 2"
FT                   /id="PRO_0000254101"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        207..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   266 AA;  29923 MW;  A3A00ECE27834855 CRC64;
     MWWFQQGLSF LPSALVIWTA AAFIFSYITA ITLHHVDPVL PYISDTGTVA PEKCLFGAML
     NIAAVLCVAT IYVRYKQVHA LNPEENRIIR LNKAGLVLGL LSCLGLSLVA NFQKTTFFAV
     HVCGAVLTFG MGSLYMFVQT ILSYQMQPKI HGKQVFWIRL LLVIWCGVSA FSMLTCSSLL
     YNGSFGADIV QKLHWNPEDK GYVLHMITTA AEWSMSLSFF GFFLTYIRDF QKISLRVEAT
     LHGLTLYDTA PCPVNNERTW LLSRDV